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SLC7A13 solute carrier family 7 member 13 [ Homo sapiens (human) ]

Gene ID: 157724, updated on 5-Jan-2022

Summary

Official Symbol
SLC7A13provided by HGNC
Official Full Name
solute carrier family 7 member 13provided by HGNC
Primary source
HGNC:HGNC:23092
See related
Ensembl:ENSG00000164893 MIM:617256
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AGT1; XAT2; AGT-1
Summary
Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in L-cystine transport; L-glutamate transmembrane transport; and aspartate transmembrane transport. Predicted to be integral component of membrane. Predicted to be active in apical plasma membrane. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Restricted expression toward kidney (RPKM 11.0) See more
Orthologs
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Genomic context

See SLC7A13 in Genome Data Viewer
Location:
8q21.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (86213909..86230381, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (87226292..87242610, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATPase H+ transporting V0 subunit d2 Neighboring gene uncharacterized LOC105375623 Neighboring gene HNF4 motif-containing MPRA enhancer 29 Neighboring gene WWP1 antisense RNA 1 Neighboring gene WW domain containing E3 ubiquitin protein ligase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC150476, MGC150477

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in L-cystine transport IEA
Inferred from Electronic Annotation
more info
 
involved_in L-glutamate transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in aspartate transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
solute carrier family 7 member 13
Names
X-amino acid transporter 2
amino acid transporter XAT2
sodium-independent aspartate/glutamate transporter 1
solute carrier family 7 (anionic amino acid transporter), member 13
solute carrier family 7, (cationic amino acid transporter, y+ system) member 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138817.3NP_620172.2  solute carrier family 7 member 13

    See identical proteins and their annotated locations for NP_620172.2

    Status: VALIDATED

    Source sequence(s)
    AC084128, AJ417661, AK055815
    Consensus CDS
    CCDS34917.1
    UniProtKB/Swiss-Prot
    Q8TCU3
    Related
    ENSP00000297524.3, ENST00000297524.8
    Conserved Domains (1) summary
    pfam13520
    Location:16398
    AA_permease_2; Amino acid permease

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    86213909..86230381 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516867.2XP_011515169.1  solute carrier family 7 member 13 isoform X1

    Conserved Domains (1) summary
    pfam13520
    Location:16389
    AA_permease_2; Amino acid permease
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