Format

Send to:

Choose Destination

CYP3A5 cytochrome P450 family 3 subfamily A member 5 [ Homo sapiens (human) ]

Gene ID: 1577, updated on 28-Nov-2021

Summary

Official Symbol
CYP3A5provided by HGNC
Official Full Name
cytochrome P450 family 3 subfamily A member 5provided by HGNC
Primary source
HGNC:HGNC:2638
See related
Ensembl:ENSG00000106258 MIM:605325
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CP35; PCN3; CYPIIIA5; P450PCN3
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein metabolizes drugs as well as the steroid hormones testosterone and progesterone. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Two pseudogenes of this gene have been identified within this cluster on chromosome 7. Expression of this gene is widely variable among populations, and a single nucleotide polymorphism that affects transcript splicing has been associated with susceptibility to hypertensions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Expression
Biased expression in small intestine (RPKM 67.4), duodenum (RPKM 57.9) and 7 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See CYP3A5 in Genome Data Viewer
Location:
7q22.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (99648194..99679996, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99245817..99277619, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene zinc finger protein 655 Neighboring gene transmembrane protein 225B Neighboring gene zinc finger and SCAN domain containing 25 Neighboring gene ADP ribosylation factor 6 pseudogene Neighboring gene CYP3A7-CYP3A51P readthrough Neighboring gene CYP3A5 promoter Neighboring gene cytochrome P450 family 3 subfamily A member 51, pseudogene Neighboring gene cytochrome P450 family 3 subfamily A member 7 Neighboring gene CYP3A7 5' regulatory region

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
An atlas of genetic influences on human blood metabolites.
GeneReviews: Not available
Essential hypertension
MedGen: C0085580 OMIM: 145500 GeneReviews: Not available
Compare labs
Tacrolimus response
MedGen: C3547403 GeneReviews: Not available
Compare labs

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31317, DKFZp686L16231

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables aromatase activity IEA
Inferred from Electronic Annotation
more info
 
enables estrogen 16-alpha-hydroxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables estrogen 16-alpha-hydroxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 
enables monooxygenase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables monooxygenase activity TAS
Traceable Author Statement
more info
 
enables oxidoreductase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables oxygen binding TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables retinoic acid 4-hydroxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables steroid hydroxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables testosterone 6-beta-hydroxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in aflatoxin metabolic process TAS
Traceable Author Statement
more info
 
involved_in alkaloid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in estrogen metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipid hydroxylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in oxidative demethylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in oxidative demethylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in retinoic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in retinol metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in steroid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in steroid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in xenobiotic catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in intracellular membrane-bounded organelle TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
cytochrome P450 3A5
Names
aryl hydrocarbon hydroxylase
cytochrome P450 HLp2
cytochrome P450, family 3, subfamily A, polypeptide 5
cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 5
cytochrome P450-PCN3
flavoprotein-linked monooxygenase
microsomal monooxygenase
xenobiotic monooxygenase
NP_000768.1
NP_001177413.1
NP_001278758.1
NP_001278759.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007938.2 RefSeqGene

    Range
    5003..36805
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1431

mRNA and Protein(s)

  1. NM_000777.5NP_000768.1  cytochrome P450 3A5 isoform 1

    See identical proteins and their annotated locations for NP_000768.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA076026, BC033862, DC383127
    Consensus CDS
    CCDS5672.1
    UniProtKB/Swiss-Prot
    P20815
    Related
    ENSP00000222982.4, ENST00000222982.8
    Conserved Domains (1) summary
    pfam00067
    Location:39492
    p450; Cytochrome P450
  2. NM_001190484.3NP_001177413.1  cytochrome P450 3A5 isoform 2

    See identical proteins and their annotated locations for NP_001177413.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks several exons and uses an alternate 3' exon, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC005020, AK299002, BC022298
    Consensus CDS
    CCDS55134.1
    UniProtKB/Swiss-Prot
    P20815
    Related
    ENSP00000401269.1, ENST00000439761.3
    Conserved Domains (1) summary
    cl12078
    Location:39100
    p450; Cytochrome P450
  3. NM_001291829.2NP_001278758.1  cytochrome P450 3A5 isoform 3

    See identical proteins and their annotated locations for NP_001278758.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR and uses a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AA076026, BC025176, DC383127
    Related
    ENST00000461920.5
    Conserved Domains (1) summary
    pfam00067
    Location:5379
    p450; Cytochrome P450
  4. NM_001291830.2NP_001278759.1  cytochrome P450 3A5 isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in its 5' UTR and uses an alternate start codon, compared to variant 1. The encoded isoform (4) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AA076026, AK296205, DC383127
    UniProtKB/TrEMBL
    B7Z3P6
    Conserved Domains (1) summary
    pfam00067
    Location:29482
    p450; Cytochrome P450

RNA

  1. NR_033807.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) includes 3 alternate internal segments, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AA076026, BC025176, BX537676, BX648856
    Related
    ENST00000339843.6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    99648194..99679996 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_033810.1: Suppressed sequence

    Description
    NR_033810.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
  2. NR_033811.1: Suppressed sequence

    Description
    NR_033811.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
  3. NR_033812.1: Suppressed sequence

    Description
    NR_033812.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
Support Center