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CYP3A5 cytochrome P450 family 3 subfamily A member 5 [ Homo sapiens (human) ]

Gene ID: 1577, updated on 6-Sep-2017
Official Symbol
CYP3A5provided by HGNC
Official Full Name
cytochrome P450 family 3 subfamily A member 5provided by HGNC
Primary source
HGNC:HGNC:2638
See related
Ensembl:ENSG00000106258 MIM:605325; Vega:OTTHUMG00000156724
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CP35; PCN3; CYPIIIA5; P450PCN3
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein metabolizes drugs as well as the steroid hormones testosterone and progesterone. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Two pseudogenes of this gene have been identified within this cluster on chromosome 7. Expression of this gene is widely variable among populations, and a single nucleotide polymorphism that affects transcript splicing has been associated with susceptibility to hypertensions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Orthologs
Location:
7q22.1
Exon count:
18
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 7 NC_000007.14 (99648189..99680026, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99245813..99277636, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene transmembrane protein 225B Neighboring gene zinc finger and SCAN domain containing 25 Neighboring gene ADP ribosylation factor 6 pseudogene Neighboring gene CYP3A7-CYP3A51P readthrough Neighboring gene cytochrome P450 family 3 subfamily A member 51, pseudogene Neighboring gene cytochrome P450 family 3 subfamily A member 7

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Essential hypertension
MedGen: C0085580 OMIM: 145500 GeneReviews: Not available
Compare labs
Tacrolimus response
MedGen: C3547403 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ31317, DKFZp686L16231

Gene Ontology Provided by GOA

Function Evidence Code Pubs
aromatase activity IEA
Inferred from Electronic Annotation
more info
 
estrogen 16-alpha-hydroxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
heme binding IEA
Inferred from Electronic Annotation
more info
 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
monooxygenase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
oxidoreductase activity IDA
Inferred from Direct Assay
more info
PubMed 
oxygen binding TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
alkaloid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
drug catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
lipid hydroxylation IDA
Inferred from Direct Assay
more info
PubMed 
oxidative demethylation IDA
Inferred from Direct Assay
more info
PubMed 
steroid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
intracellular membrane-bounded organelle TAS
Traceable Author Statement
more info
PubMed 
organelle membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
cytochrome P450 3A5
Names
aryl hydrocarbon hydroxylase
cytochrome P450 HLp2
cytochrome P450, family 3, subfamily A, polypeptide 5
cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 5
cytochrome P450-PCN3
flavoprotein-linked monooxygenase
microsomal monooxygenase
xenobiotic monooxygenase
NP_000768.1
NP_001177413.1
NP_001278758.1
NP_001278759.1
XP_006715922.1
XP_011514145.1
XP_016867270.1
XP_016867271.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007938.1 RefSeqGene

    Range
    4973..36810
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000777.4NP_000768.1  cytochrome P450 3A5 isoform 1

    See identical proteins and their annotated locations for NP_000768.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA076026, BC033862, DC383127
    Consensus CDS
    CCDS5672.1
    UniProtKB/Swiss-Prot
    P20815
    Related
    ENSP00000222982.4, OTTHUMP00000210469, ENST00000222982.8, OTTHUMT00000345469
    Conserved Domains (1) summary
    pfam00067
    Location:39492
    p450; Cytochrome P450
  2. NM_001190484.2NP_001177413.1  cytochrome P450 3A5 isoform 2

    See identical proteins and their annotated locations for NP_001177413.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks several exons and uses an alternate 3' exon, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK299002, BC022298, DC383127
    Consensus CDS
    CCDS55134.1
    UniProtKB/Swiss-Prot
    P20815
    Related
    ENSP00000401269.1, OTTHUMP00000210470, ENST00000439761.1, OTTHUMT00000345471
    Conserved Domains (1) summary
    cl12078
    Location:39100
    p450; Cytochrome P450
  3. NM_001291829.1NP_001278758.1  cytochrome P450 3A5 isoform 3

    See identical proteins and their annotated locations for NP_001278758.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR and uses a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AA076026, BC025176, DC383127
    Conserved Domains (1) summary
    pfam00067
    Location:5379
    p450; Cytochrome P450
  4. NM_001291830.1NP_001278759.1  cytochrome P450 3A5 isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in its 5' UTR and uses an alternate start codon, compared to variant 1. The encoded isoform (4) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AA076026, AK296205, DC383127
    UniProtKB/TrEMBL
    B7Z3P6
    Conserved Domains (1) summary
    pfam00067
    Location:29482
    p450; Cytochrome P450

RNA

  1. NR_033807.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) includes 3 alternate internal segments, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AA076026, BC025176, BX537676, BX648856, DC383127
    Related
    ENST00000339843.6

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p7 Primary Assembly

    Range
    99648189..99680026 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515843.1XP_011514145.1  cytochrome P450 3A5 isoform X1

    See identical proteins and their annotated locations for XP_011514145.1

    Conserved Domains (1) summary
    pfam00067
    Location:5379
    p450; Cytochrome P450
  2. XM_017011781.1XP_016867270.1  cytochrome P450 3A5 isoform X1

    Conserved Domains (1) summary
    pfam00067
    Location:5379
    p450; Cytochrome P450
  3. XM_017011782.1XP_016867271.1  cytochrome P450 3A5 isoform X3

    Conserved Domains (1) summary
    pfam00067
    Location:1312
    p450; Cytochrome P450
  4. XM_006715859.2XP_006715922.1  cytochrome P450 3A5 isoform X2

    See identical proteins and their annotated locations for XP_006715922.1

    Conserved Domains (1) summary
    cl12078
    Location:39343
    p450; Cytochrome P450

RNA

  1. XR_001744569.1 RNA Sequence

  2. XR_001744568.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 Alternate CHM1_1.1

    Range
    99175906..99207748 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_033810.1: Suppressed sequence

    Description
    NR_033810.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
  2. NR_033811.1: Suppressed sequence

    Description
    NR_033811.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
  3. NR_033812.1: Suppressed sequence

    Description
    NR_033812.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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