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TDRP testis development related protein [ Homo sapiens (human) ]

Gene ID: 157695, updated on 13-Mar-2020

Summary

Official Symbol
TDRPprovided by HGNC
Official Full Name
testis development related proteinprovided by HGNC
Primary source
HGNC:HGNC:26951
See related
Ensembl:ENSG00000180190
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Inm01; TDRP1; TDRP2; C8orf42
Expression
Broad expression in placenta (RPKM 17.5), thyroid (RPKM 13.8) and 22 other tissues See more
Orthologs

Genomic context

See TDRP in Genome Data Viewer
Location:
8p23.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (489790..545781, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (439790..495781, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 87 member A Neighboring gene F-box protein 25 Neighboring gene glutamate rich 1 Neighboring gene uncharacterized LOC401442 Neighboring gene DLG associated protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Mayo Genome Consortia: a genotype-phenotype resource for genome-wide association studies with an application to the analysis of circulating bilirubin levels.
NHGRI GWA Catalog

General gene information

Markers

Homology

Clone Names

  • FLJ44221, DKFZp686J15216

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
spermatogenesis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
testis development-related protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256113.1NP_001243042.1  testis development-related protein isoform 2

    See identical proteins and their annotated locations for NP_001243042.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2, also known as TDRP2) lacks a portion of the 5' and 3' UTRs, and differs in the 3' coding region, compared to variant 1. The encoded isoform (2) has a distinct and longer C-terminus, compared to isoform 1.
    Source sequence(s)
    AC090135, BC033779, BX648606, FJ381685
    Consensus CDS
    CCDS59090.1
    UniProtKB/Swiss-Prot
    Q86YL5
    Related
    ENSP00000408126.2, ENST00000427263.6
    Conserved Domains (1) summary
    pfam15683
    Location:41167
    TDRP; Testis development-related protein
  2. NM_001369716.1NP_001356645.1  testis development-related protein isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon and initiates translation from an alternate AUG start codon compared to variant 1. The resulting isoform (3) is longer with a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC083964, AY194292
    Conserved Domains (1) summary
    pfam15683
    Location:51195
    TDRP; Testis development-related protein
  3. NM_175075.4NP_778250.2  testis development-related protein isoform 1

    See identical proteins and their annotated locations for NP_778250.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, also known as TDRP1) represents the longer transcript but encodes the shorter isoform (1).
    Source sequence(s)
    AC090691, AY194292, BC033779, BX648606, CN430635, DB461052
    Consensus CDS
    CCDS47759.1
    UniProtKB/Swiss-Prot
    Q86YL5
    Related
    ENSP00000479558.1, ENST00000613071.1
    Conserved Domains (1) summary
    pfam15683
    Location:41185
    TDRP; Testis development-related protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    489790..545781 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006716232.4XP_006716295.1  testis development-related protein isoform X2

    See identical proteins and their annotated locations for XP_006716295.1

    UniProtKB/Swiss-Prot
    Q86YL5
    Related
    ENSP00000315111.6, ENST00000324079.10
    Conserved Domains (1) summary
    pfam15683
    Location:41185
    TDRP; Testis development-related protein
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