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FBXO16 F-box protein 16 [ Homo sapiens (human) ]

Gene ID: 157574, updated on 24-Nov-2020

Summary

Official Symbol
FBXO16provided by HGNC
Official Full Name
F-box protein 16provided by HGNC
Primary source
HGNC:HGNC:13618
See related
Ensembl:ENSG00000214050 MIM:608519
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBX16
Summary
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Expression
Broad expression in thyroid (RPKM 3.3), brain (RPKM 2.1) and 21 other tissues See more
Orthologs

Genomic context

See FBXO16 in Genome Data Viewer
Location:
8p21.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (28428412..28490229, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (28285925..28347835, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene zinc finger protein 395 Neighboring gene RNA, U6 small nuclear 178, pseudogene Neighboring gene VISTA enhancer hs1329 Neighboring gene frizzled class receptor 3 Neighboring gene microRNA 4288

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: ZNF395

Homology

Clone Names

  • MGC125923, MGC125924, MGC125925

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001258211.2NP_001245140.1  F-box only protein 16 isoform 2

    See identical proteins and their annotated locations for NP_001245140.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
    Source sequence(s)
    AA765256, AC025871, BC102028
    Consensus CDS
    CCDS59099.1
    UniProtKB/Swiss-Prot
    Q8IX29
    Related
    ENSP00000429687.1, ENST00000518734.5
    Conserved Domains (1) summary
    pfam12937
    Location:80123
    F-box-like; F-box-like
  2. NM_172366.4NP_758954.1  F-box only protein 16 isoform 1

    See identical proteins and their annotated locations for NP_758954.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AC025871, AF453435, CB134505
    Consensus CDS
    CCDS6068.1
    UniProtKB/Swiss-Prot
    Q8IX29
    Related
    ENSP00000369604.2, ENST00000380254.7
    Conserved Domains (1) summary
    pfam12937
    Location:92129
    F-box-like; F-box-like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    28428412..28490229 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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