U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

RDH10 retinol dehydrogenase 10 [ Homo sapiens (human) ]

Gene ID: 157506, updated on 11-Jun-2025
Official Symbol
RDH10provided by HGNC
Official Full Name
retinol dehydrogenase 10provided by HGNC
Primary source
HGNC:HGNC:19975
See related
Ensembl:ENSG00000121039 MIM:607599; AllianceGenome:HGNC:19975
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SDR16C4
Summary
This gene encodes a retinol dehydrogenase, which converts all-trans-retinol to all-trans-retinal, with preference for NADP as a cofactor. Studies in mice suggest that this protein is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development. [provided by RefSeq, Dec 2011]
Expression
Ubiquitous expression in kidney (RPKM 18.4), gall bladder (RPKM 13.9) and 24 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table
See RDH10 in Genome Data Viewer
Location:
8q21.11
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (73294602..73325281)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (73724122..73754883)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (74206837..74237516)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene chromosome 8 open reading frame 89 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:74197691-74198192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:74198193-74198692 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:74205120-74205828 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:74205829-74206536 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19287 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:74211031-74211531 Neighboring gene peroxiredoxin like 2A pseudogene 2 Neighboring gene NANOG hESC enhancer GRCh37_chr8:74216479-74216980 Neighboring gene RDH10 antisense RNA 1 Neighboring gene ribosomal protein L7 Neighboring gene uncharacterized LOC105375899 Neighboring gene STAU2 antisense RNA 1 Neighboring gene staufen double-stranded RNA binding protein 2

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EBI GWAS Catalog

Description
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
EBI GWAS Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Process Evidence Code Pubs
acts_upstream_of_or_within animal organ morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within bud elongation involved in lung branching IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within ear development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within embryonic camera-type eye development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within embryonic forelimb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within embryonic organ development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within embryonic viscerocranium morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within gonad development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within metanephros development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neural crest cell development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within nose development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of retinoic acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within primary lung bud formation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of hormone levels IEA
Inferred from Electronic Annotation
more info
 
involved_in retinal metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within retinoic acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in retinoid metabolic process TAS
Traceable Author Statement
more info
 
involved_in retinol metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in retinol metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within visual perception IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
NOT located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
retinol dehydrogenase 10
Names
retinol dehydrogenase 10 (all-trans)
short chain dehydrogenase/reductase family 16C member 4
NP_742034.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172037.5NP_742034.1  retinol dehydrogenase 10

    See identical proteins and their annotated locations for NP_742034.1

    Status: REVIEWED

    Source sequence(s)
    AC111149, AF456765, BC067131, BM472905, BM804062, BM979260, CD110145
    Consensus CDS
    CCDS6213.1
    UniProtKB/Swiss-Prot
    Q8IZV5
    Related
    ENSP00000240285.5, ENST00000240285.10
    Conserved Domains (1) summary
    cd05339
    Location:38307
    17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    73294602..73325281
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    73724122..73754883
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)