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CDCA2 cell division cycle associated 2 [ Homo sapiens (human) ]

Gene ID: 157313, updated on 1-Jun-2020

Summary

Official Symbol
CDCA2provided by HGNC
Official Full Name
cell division cycle associated 2provided by HGNC
Primary source
HGNC:HGNC:14623
See related
Ensembl:ENSG00000184661 MIM:618785
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PPP1R81; Repo-Man
Summary
This gene encodes a targeting subunit of the cell-cycle associated protein, protein phosphatase 1, with a role in targeting this protein to chromatin during anaphase. These two proteins comprise a phosphatase complex that is involved in nuclear envelope reformation and regulation of the DNA damage response. The encoded protein may also play a role in cancer progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Expression
Biased expression in testis (RPKM 7.7), lymph node (RPKM 1.9) and 9 other tissues See more
Orthologs

Genomic context

See CDCA2 in Genome Data Viewer
Location:
8p21.2
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (25458557..25511308)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (25316275..25365425)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 10380 Neighboring gene gonadotropin releasing hormone 1 Neighboring gene potassium channel tetramerization domain containing 9 Neighboring gene uncharacterized LOC107986933 Neighboring gene uncharacterized LOC105379333 Neighboring gene uncharacterized LOC105379332

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25804, MGC129906, MGC129907

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
chromosome segregation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
chromosome IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
cell division cycle-associated protein 2
Names
protein phosphatase 1, regulatory subunit 81
recruits PP1 onto mitotic chromatin at anaphase protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317906.1NP_001304835.1  cell division cycle-associated protein 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) retains a 5' intron resulting in a distinct 5' UTR and the use of an alternate translation start site compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus compared to variant 1.
    Source sequence(s)
    AA678348, AI022757, AK292505, AL833396, DB093475
    Consensus CDS
    CCDS83266.1
    UniProtKB/Swiss-Prot
    Q69YH5
    UniProtKB/TrEMBL
    A8K8Z0, E9PEI0
    Related
    ENSP00000370040.3, ENST00000380665.3
    Conserved Domains (1) summary
    pfam15276
    Location:375433
    PP1_bind; Protein phosphatase 1 binding
  2. NM_001317907.1NP_001304836.1  cell division cycle-associated protein 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AA678348, AI022757, AK292505, AK299278, AL833396, DB093475
    UniProtKB/Swiss-Prot
    Q69YH5
    UniProtKB/TrEMBL
    A8K8Z0, B7Z5Q5
    Conserved Domains (1) summary
    pfam15276
    Location:390448
    PP1_bind; Protein phosphatase 1 binding
  3. NM_152562.4NP_689775.2  cell division cycle-associated protein 2 isoform 1

    See identical proteins and their annotated locations for NP_689775.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA678348, AI022757, AK299278, AL833396, BC015691
    Consensus CDS
    CCDS6049.1
    UniProtKB/Swiss-Prot
    Q69YH5
    UniProtKB/TrEMBL
    B7Z5Q5
    Related
    ENSP00000328228.3, ENST00000330560.8
    Conserved Domains (1) summary
    pfam15276
    Location:390448
    PP1_bind; Protein phosphatase 1 binding

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    25458557..25511308
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544417.3XP_011542719.1  cell division cycle-associated protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011542719.1

    Conserved Domains (1) summary
    pfam15276
    Location:419477
    PP1_bind; Protein phosphatase 1 binding
  2. XM_011544416.2XP_011542718.1  cell division cycle-associated protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011542718.1

    Conserved Domains (1) summary
    pfam15276
    Location:419477
    PP1_bind; Protein phosphatase 1 binding
  3. XM_011544415.1XP_011542717.1  cell division cycle-associated protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011542717.1

    Conserved Domains (1) summary
    pfam15276
    Location:419477
    PP1_bind; Protein phosphatase 1 binding
  4. XM_006716294.2XP_006716357.1  cell division cycle-associated protein 2 isoform X3

    Conserved Domains (1) summary
    pfam15276
    Location:395453
    PP1_bind; Protein phosphatase 1 binding
  5. XM_024447073.1XP_024302841.1  cell division cycle-associated protein 2 isoform X4

    Conserved Domains (1) summary
    pfam15276
    Location:419477
    PP1_bind; Protein phosphatase 1 binding
  6. XM_011544418.1XP_011542720.1  cell division cycle-associated protein 2 isoform X2

    Conserved Domains (1) summary
    pfam15276
    Location:414472
    PP1_bind; Protein phosphatase 1 binding

RNA

  1. XR_949377.1 RNA Sequence

  2. XR_001745479.1 RNA Sequence

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