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PEBP4 phosphatidylethanolamine binding protein 4 [ Homo sapiens (human) ]

Gene ID: 157310, updated on 7-Jul-2024

Summary

Official Symbol
PEBP4provided by HGNC
Official Full Name
phosphatidylethanolamine binding protein 4provided by HGNC
Primary source
HGNC:HGNC:28319
See related
Ensembl:ENSG00000134020 MIM:612473; AllianceGenome:HGNC:28319
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CORK1; CORK-1; PEBP-4; hPEBP4; PRO4408; GWTM1933; HEL-S-300
Summary
The phosphatidylethanolamine (PE)-binding proteins, including PEBP4, are an evolutionarily conserved family of proteins with pivotal biologic functions, such as lipid binding and inhibition of serine proteases (Wang et al., 2004 [PubMed 15302887]).[supplied by OMIM, Dec 2008]
Expression
Biased expression in lung (RPKM 23.8), heart (RPKM 14.9) and 5 other tissues See more
Orthologs
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Genomic context

See PEBP4 in Genome Data Viewer
Location:
8p21.3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (22713251..22941077, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (22987819..23216048, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (22570764..22798590, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19009 Neighboring gene uncharacterized LOC105379321 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19010 Neighboring gene uncharacterized LOC107986926 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19011 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19012 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27087 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27088 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27089 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27090 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22572425-22573228 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27092 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27093 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27094 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27095 Neighboring gene MPRA-validated peak6940 silencer Neighboring gene uncharacterized LOC124901908 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:22601507-22602706 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19013 Neighboring gene uncharacterized LOC107986925 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27096 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22634644-22635144 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22635145-22635645 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22640438-22641124 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22641125-22641811 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22642499-22643184 Neighboring gene uncharacterized LOC105379325 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:22669609-22669787 Neighboring gene uncharacterized LOC124901906 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr8:22721642-22722218 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22722219-22722794 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19015 Neighboring gene uncharacterized LOC101929237 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27097 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22744265-22744765 Neighboring gene uncharacterized LOC124901907 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:22760306-22760493 Neighboring gene Sharpr-MPRA regulatory region 3596 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22769137-22769908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22769909-22770680 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22777059-22777987 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22809645-22810276 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22810277-22810907 Neighboring gene uncharacterized LOC107984124 Neighboring gene NANOG hESC enhancer GRCh37_chr8:22814761-22815262 Neighboring gene VISTA enhancer hs1927 Neighboring gene Rho related BTB domain containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27100 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22845205-22845961 Neighboring gene RNA, 7SL, cytoplasmic 303, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19017 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19018 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19019 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22861268-22861793 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22861794-22862318 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr8:22866186-22866771 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22871840-22872604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27102 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:22876025-22876192 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22876488-22877052 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22877053-22877615 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:22885758-22886258 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:22886259-22886759 Neighboring gene TNF receptor superfamily member 10b Neighboring gene Sharpr-MPRA regulatory region 6582 Neighboring gene TNFRSF10B antisense RNA 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:22921484-22922683 Neighboring gene TNFRSF10B 5' regulatory region

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide association meta-analysis of preschool internalizing problems.
EBI GWAS Catalog
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
EBI GWAS Catalog
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC22776

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 

General protein information

Preferred Names
phosphatidylethanolamine-binding protein 4
Names
cousin-of-RKIP 1 protein
epididymis secretory protein Li 300
epididymis secretory sperm binding protein
protein cousin-of-RKIP 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363233.2NP_001350162.1  phosphatidylethanolamine-binding protein 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC105046, AC134389, AY359109, AY730275
    Consensus CDS
    CCDS43724.1
    UniProtKB/Swiss-Prot
    Q5EVA1, Q8WW74, Q96S96
    UniProtKB/TrEMBL
    V9HW76
    Conserved Domains (1) summary
    cd00866
    Location:46197
    PEBP_euk; PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes
  2. NM_144962.3NP_659399.2  phosphatidylethanolamine-binding protein 4 precursor

    See identical proteins and their annotated locations for NP_659399.2

    Status: VALIDATED

    Source sequence(s)
    AC037441, AC105046, AY037148, AY359109, BF853000
    Consensus CDS
    CCDS43724.1
    UniProtKB/Swiss-Prot
    Q5EVA1, Q8WW74, Q96S96
    UniProtKB/TrEMBL
    V9HW76
    Related
    ENSP00000256404.6, ENST00000256404.8
    Conserved Domains (1) summary
    cd00866
    Location:46197
    PEBP_euk; PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    22713251..22941077 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013103.2XP_016868592.1  phosphatidylethanolamine-binding protein 4 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    22987819..23216048 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054359810.1XP_054215785.1  phosphatidylethanolamine-binding protein 4 isoform X1