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CYP2J2 cytochrome P450 family 2 subfamily J member 2 [ Homo sapiens (human) ]

Gene ID: 1573, updated on 5-Aug-2018

Summary

Official Symbol
CYP2J2provided by HGNC
Official Full Name
cytochrome P450 family 2 subfamily J member 2provided by HGNC
Primary source
HGNC:HGNC:2634
See related
Ensembl:ENSG00000134716 MIM:601258; Vega:OTTHUMG00000008991
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPJ2; CYPIIJ2
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant enzyme responsible for epoxidation of endogenous arachidonic acid in cardiac tissue. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016]
Expression
Biased expression in small intestine (RPKM 44.5), heart (RPKM 35.2) and 10 other tissues See more
Orthologs

Genomic context

See CYP2J2 in Genome Data Viewer
Location:
1p32.1
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (59893308..59926798, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (60358980..60392445, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101926944 Neighboring gene uncharacterized LOC105378758 Neighboring gene hook microtubule tethering protein 1 Neighboring gene RNA, 7SL, cytoplasmic 475, pseudogene Neighboring gene chromosome 1 open reading frame 87

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
arachidonic acid 11,12-epoxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
arachidonic acid 14,15-epoxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
arachidonic acid epoxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
arachidonic acid epoxygenase activity TAS
Traceable Author Statement
more info
 
aromatase activity IEA
Inferred from Electronic Annotation
more info
 
heme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heme binding IEA
Inferred from Electronic Annotation
more info
 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
linoleic acid epoxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
monooxygenase activity TAS
Traceable Author Statement
more info
 
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
steroid hydroxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
epoxygenase P450 pathway IDA
Inferred from Direct Assay
more info
PubMed 
epoxygenase P450 pathway TAS
Traceable Author Statement
more info
 
exogenous drug catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
icosanoid metabolic process TAS
Traceable Author Statement
more info
PubMed 
linoleic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
organic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidation-reduction process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
regulation of heart contraction TAS
Traceable Author Statement
more info
PubMed 
xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
xenobiotic metabolic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
organelle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cytochrome P450 2J2
Names
arachidonic acid epoxygenase
cytochrome P450, family 2, subfamily J, polypeptide 2
cytochrome P450, subfamily IIJ (arachidonic acid epoxygenase) polypeptide 2
flavoprotein-linked monooxygenase
microsomal monooxygenase
NP_000766.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007931.1 RefSeqGene

    Range
    4954..38444
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000775.3NP_000766.2  cytochrome P450 2J2

    See identical proteins and their annotated locations for NP_000766.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the protein-coding transcript.
    Source sequence(s)
    BC032594, BI457601
    Consensus CDS
    CCDS613.1
    UniProtKB/Swiss-Prot
    P51589
    Related
    ENSP00000360247.3, OTTHUMP00000010550, ENST00000371204.3, OTTHUMT00000024940
    Conserved Domains (1) summary
    pfam00067
    Location:44497
    p450; Cytochrome P450

RNA

  1. NR_134981.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC032594, BI457601, CD013972
    Related
    ENST00000466095.5
  2. NR_134982.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC113175, BC032594, BI457601, CD013973
    Related
    ENST00000469406.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    59893308..59926798 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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