Format

Send to:

Choose Destination

PRAG1 PEAK1 related, kinase-activating pseudokinase 1 [ Homo sapiens (human) ]

Gene ID: 157285, updated on 13-Mar-2020

Summary

Official Symbol
PRAG1provided by HGNC
Official Full Name
PEAK1 related, kinase-activating pseudokinase 1provided by HGNC
Primary source
HGNC:HGNC:25438
See related
Ensembl:ENSG00000275342 MIM:617344
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NACK; PEAK2; SGK223; PRAGMIN
Summary
This gene encodes an enzyme that belongs to the tyrosine protein kinase family. A similar protein in rat binds to Rho family GTPase 2 (Rnd2) and regulates neurite outgrowth via activation of Ras homolog gene family, member A (RhoA). [provided by RefSeq, Mar 2014]
Expression
Broad expression in thyroid (RPKM 9.5), fat (RPKM 5.5) and 22 other tissues See more
Orthologs

Genomic context

See PRAG1 in Genome Data Viewer
Location:
8p23.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (8317736..8386439, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (8175258..8243941, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 85 member B Neighboring gene uncharacterized LOC112268014 Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 7 pseudogene 1 Neighboring gene family with sequence similarity 86, member A pseudogene Neighboring gene ALG1 like 13, pseudogene Neighboring gene uncharacterized LOC105379222 Neighboring gene uncharacterized LOC107986913

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp761P0423

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of Rho protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of Notch signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell motility ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell shape ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
inactive tyrosine-protein kinase PRAG1
Names
PEAK family member 2
Pragmin, RND2 effector protein
homolog of rat pragma of Rnd2
sugen kinase 223
tyrosine-protein kinase PRAG1
tyrosine-protein kinase SgK223
NP_001074295.2
NP_001356688.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080826.3NP_001074295.2  inactive tyrosine-protein kinase PRAG1

    See identical proteins and their annotated locations for NP_001074295.2

    Status: VALIDATED

    Source sequence(s)
    ABBA01026926, AC068353, AC103957, AK122582, AL833872, BX420505
    Consensus CDS
    CCDS43706.1
    UniProtKB/Swiss-Prot
    Q86YV5
    Related
    ENSP00000481109.1, ENST00000615670.5
    Conserved Domains (2) summary
    PHA03247
    Location:371631
    PHA03247; large tegument protein UL36; Provisional
    cl21453
    Location:10391330
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001369759.1NP_001356688.1  inactive tyrosine-protein kinase PRAG1

    Status: VALIDATED

    Source sequence(s)
    ABBA01026926, AC068353, AC103957, AK122582, AL833872, BX420505
    Conserved Domains (2) summary
    PHA03247
    Location:371631
    PHA03247; large tegument protein UL36; Provisional
    cl21453
    Location:10391330
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. NR_163138.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    ABBA01026926, AC068353, AC103957, AK122582, AL833872, BX420505

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    8317736..8386439 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654717.1 Reference GRCh38.p13 PATCHES

    Range
    4961412..5030116
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center