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CYP2F1 cytochrome P450 family 2 subfamily F member 1 [ Homo sapiens (human) ]

Gene ID: 1572, updated on 4-Feb-2026
Official Symbol
CYP2F1provided by HGNC
Official Full Name
cytochrome P450 family 2 subfamily F member 1provided by HGNC
Primary source
HGNC:HGNC:2632
See related
Ensembl:ENSG00000197446 MIM:124070; AllianceGenome:HGNC:2632
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C2F1; CYP2F; CYPIIF1
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to dehydrogenate 3-methylindole, an endogenous toxin derived from the fermentation of tryptophan, as well as xenobiotic substrates such as naphthalene and ethoxycoumarin. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See CYP2F1 in Genome Data Viewer
Location:
19q13.2
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (41114432..41128381)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (43935308..43949263)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (41620337..41634286)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 2 subfamily G member 2, pseudogene Neighboring gene cytochrome P450 family 2 subfamily A member 13 Neighboring gene uncharacterized LOC124904790 Neighboring gene cytochrome P450 family 2 subfamily T member 3, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:41664953-41665516 Neighboring gene Sharpr-MPRA regulatory region 1789 Neighboring gene ribosomal protein L36 pseudogene 16

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Association between effectiveness of tuberculosis treatment and cytochrome P-4502E1 polymorphism of the patients. Antonenko P, et al. Int J Mycobacteriol, 2017 Oct-Dec. PMID 29171455
  2. Localization of CYP2F1 by multipoint linkage analysis and pulsed-field gel electrophoresis. Bale AE, et al. Genomics, 1991 May. PMID 2045106
  3. Quantification of multiple human cytochrome P450 mRNA molecules using competitive reverse transcriptase-PCR. Andersen MR, et al. DNA Cell Biol, 1998 Mar. PMID 9539103
  4. CYP2F1 genetic polymorphism: identification of interethnic variations. Tournel G, et al. Xenobiotica, 2007 Dec. PMID 17943660
  5. Molecular analysis of the CYP2F1 gene: identification of a frequent non-functional allelic variant. Tournel G, et al. Mutat Res, 2007 Apr 1. PMID 17327131

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Polymorphism of cytochrome P-4502E1 (CYP2E1) genotype is an important criterion for the development of hepatotoxicity before and during TB treatment.
    Title: Association between effectiveness of tuberculosis treatment and cytochrome P-4502E1 polymorphism of the patients.
  2. Tissue distribution of transgenic mRNA expression agrees well with the known respiratory tract-selective expression of CYP2A13 and CYP2F1 and hepatic expression of CYP2B6 in humans.
    Title: Generation and characterization of a CYP2A13/2B6/2F1-transgenic mouse model.
  3. Patients with occupational chronic bronchitis and healthy workers significantly differed from each other in the frequency distribution of the genotypes ofthe CYP2F1 (rs11399890, c.14_15insC
    Title: [Polymorphic markers of the CYP1B1 (4326C > G), CYP2F1 (c.14_15insC), CYP2J2 (-76G > T), and CYP2S1 (13106C > T and 13255A > G) genes and genetic predisposition to chronic respiratory diseases induced by smoking and occupational factors].
  4. Association analysis of CYP2F1 gene insertion variant with chronic obstructive pulmonary disease have shown high frequency (87.5%) of normal allele in Tatars patients with very severe stage and manifestation of chronic obstructive pulmonary disease.
    Title: [The CYP1B1 and CYP2F1 genes polymorphisms frequency in three ethnic groups of Bashkortostan and chronic obstructive pulmonary disease patients].
  5. A lot of genetic polymorphism of CYP2F1 gene is found in Guangdong population of China, however, no single genetic polymorphism associated with the individual susceptibility to nasopharyngeal carcinoma can be identified.
    Title: [Study on genetic polymorphisms of CYP2F1 gene in Guangdong population of China].
  6. Observational study of genotype prevalence. (HuGE Navigator)
    Title: CYP2F1 genetic polymorphism: identification of interethnic variations.
  7. Observational study of gene-disease association. (HuGE Navigator)
    Title: [The CYP1B1 and CYP2F1 genes polymorphisms frequency in three ethnic groups of Bashkortostan and chronic obstructive pulmonary disease patients].
  8. a novel LSF(lung-specific factor) and its consensus sequence that may control tissue-specific expression of CYP2F1.
    Title: Characterization of the human lung CYP2F1 gene and identification of a novel lung-specific binding motif.
  9. 24 novel mutations distributed in the promoter region of the gene, as well as in the coding regions and their flanking intronic sequences;the CYP2F1 genetic polymorphism has no implications in the pathogenesis of lung cancer
    Title: Molecular analysis of the CYP2F1 gene: identification of a frequent non-functional allelic variant.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Markers

Homology

Clone Names

  • MGC126121

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables arachidonate epoxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity TAS
Traceable Author Statement
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IEA
Inferred from Electronic Annotation
more info
  
enables oxygen binding IEA
Inferred from Electronic Annotation
more info
  
enables oxygen binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in epoxygenase P450 pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in naphthalene catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in xenobiotic metabolic process TAS
Traceable Author Statement
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
cytochrome P450 2F1
Names
cytochrome P450, family 2, subfamily F, polypeptide 1
cytochrome P450, subfamily IIF, polypeptide 1
flavoprotein-linked monooxygenase
microsomal monooxygenase
xenobiotic monooxygenase
NP_000765.2
XP_047294236.1
XP_047294237.1
XP_047294238.1
XP_054175991.1
XP_054175992.1
XP_054175993.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007930.1 RefSeqGene

    Range
    4985..18934
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000774.5 → NP_000765.2  cytochrome P450 2F1

    See identical proteins and their annotated locations for NP_000765.2

    Status: REVIEWED

    Source sequence(s)
    BC109057, CB853363, DC413790
    Consensus CDS
    CCDS12572.1
    UniProtKB/Swiss-Prot
    A7KAU6, A7KAU7, A7KAU8, A7KAU9, A7KAV0, P24903, Q32MN5, Q8WWJ2
    Related
    ENSP00000333534.2, ENST00000331105.7
    Conserved Domains (1) summary
    pfam00067
    Location:31 → 488
    p450; Cytochrome P450

RNA

  1. NR_135528.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC008962, AK316498, CB853363

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    41114432..41128381
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438280.1 → XP_047294236.1  cytochrome P450 2F1 isoform X1

  2. XM_047438281.1 → XP_047294237.1  cytochrome P450 2F1 isoform X2

    UniProtKB/TrEMBL
    B4DNV7
    Related
    ENSP00000573918.1, ENST00000903859.1

  3. XM_047438282.1 → XP_047294238.1  cytochrome P450 2F1 isoform X3

    UniProtKB/TrEMBL
    B4DNV7
    Related
    ENSP00000471416.1, ENST00000532164.2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    43935308..43949263
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320016.1 → XP_054175991.1  cytochrome P450 2F1 isoform X1

  2. XM_054320017.1 → XP_054175992.1  cytochrome P450 2F1 isoform X2

    UniProtKB/TrEMBL
    B4DNV7

  3. XM_054320018.1 → XP_054175993.1  cytochrome P450 2F1 isoform X3

    UniProtKB/TrEMBL
    B4DNV7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P24903.2 GenPept UniProtKB/Swiss-Prot:P24903

Gene LinkOut

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