Format

Send to:

Choose Destination

GRK3 G protein-coupled receptor kinase 3 [ Homo sapiens (human) ]

Gene ID: 157, updated on 8-Jul-2021

Summary

Official Symbol
GRK3provided by HGNC
Official Full Name
G protein-coupled receptor kinase 3provided by HGNC
Primary source
HGNC:HGNC:290
See related
Ensembl:ENSG00000100077 MIM:109636
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BARK2; ADRBK2
Summary
The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq, Jul 2008]
Expression
Broad expression in fat (RPKM 17.4), spleen (RPKM 8.7) and 22 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See GRK3 in Genome Data Viewer
Location:
22q12.1
Exon count:
23
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (25564675..25729294)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (25960642..26125261)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene conserved acetylation island sequence 2 enhancer Neighboring gene crystallin beta B2 pseudogene 1 Neighboring gene microRNA 6817 Neighboring gene GRK3 antisense RNA 1 Neighboring gene uncharacterized LOC105372964 Neighboring gene YES1 pseudogene 1 Neighboring gene RNA, 5S ribosomal pseudogene 494 Neighboring gene myosin XVIIIB Neighboring gene MYO18B antisense RNA 1 Neighboring gene RN7SK pseudogene 169

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables beta-adrenergic receptor kinase activity TAS
Traceable Author Statement
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in desensitization of G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
beta-adrenergic receptor kinase 2
Names
adrenergic, beta, receptor kinase 2
beta-ARK-2
NP_001349707.1
NP_005151.2
XP_011528277.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362778.2NP_001349707.1  beta-adrenergic receptor kinase 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL022329, BC029563
    Conserved Domains (3) summary
    cd01240
    Location:440557
    PH_GRK2_subgroup; G Protein-Coupled Receptor Kinase 2 subgroup pleckstrin homology (PH) domain
    cd05633
    Location:72417
    STKc_GRK3; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 3
    cl02565
    Location:173
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  2. NM_005160.4NP_005151.2  beta-adrenergic receptor kinase 2

    See identical proteins and their annotated locations for NP_005151.2

    Status: REVIEWED

    Source sequence(s)
    AL022329, BC036797, BC063545, BX387339
    Consensus CDS
    CCDS13832.1
    UniProtKB/Swiss-Prot
    P35626
    UniProtKB/TrEMBL
    A0A024R1D8, Q8N433
    Related
    ENSP00000317578.4, ENST00000324198.11
    Conserved Domains (3) summary
    cd08747
    Location:30186
    RGS_GRK2_GRK3; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 2 (GRK2) and G protein-coupled receptor kinase 3 (GRK3)
    cd01240
    Location:553670
    PH_GRK2_subgroup; G Protein-Coupled Receptor Kinase 2 subgroup pleckstrin homology (PH) domain
    cd05633
    Location:185530
    STKc_GRK3; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 3

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    25564675..25729294
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529975.2XP_011528277.1  beta-adrenergic receptor kinase 2 isoform X2

    Conserved Domains (5) summary
    cd01240
    Location:388505
    PH_GRK2_subgroup; G Protein-Coupled Receptor Kinase 2 subgroup pleckstrin homology (PH) domain
    cd05633
    Location:20365
    STKc_GRK3; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 3
    pfam00069
    Location:26288
    Pkinase; Protein kinase domain
    pfam00169
    Location:395484
    PH; PH domain
    cl02565
    Location:121
    RGS; Regulator of G protein signaling (RGS) domain superfamily

RNA

  1. XR_001755175.1 RNA Sequence

  2. XR_937823.1 RNA Sequence

Support Center