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Tmprss2 transmembrane serine protease 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 156435, updated on 24-Jul-2025
Official Symbol
Tmprss2provided by RGD
Official Full Name
transmembrane serine protease 2provided by RGD
Primary source
RGD:620766
See related
Ensembl:ENSRNOG00000001976 AllianceGenome:RGD:620766
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in protein autoprocessing. Predicted to be located in nucleoplasm and plasma membrane. Orthologous to human TMPRSS2 (transmembrane serine protease 2). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in Kidney (RPKM 244.3), Lung (RPKM 71.7) and 4 other tissues See more
Orthologs
human mouse all
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See Tmprss2 in Genome Data Viewer
Location:
11q12
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (50403707..50443224, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (36934306..36973779, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (38063914..38103406, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene FAM3 metabolism regulating signaling molecule B Neighboring gene uncharacterized LOC134480979 Neighboring gene MX dynamin like GTPase 2 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene ornithine decarboxylase antizyme 1, pseudogene 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Obesogenic and Ketogenic Diets Distinctly Regulate the SARS-CoV-2 Entry Proteins ACE2 and TMPRSS2 and the Renin-Angiotensin System in Rat Lung and Heart Tissues. Da Eira D, et al. Nutrients, 2021 Sep 25. PMID 34684358, Free PMC Article
  2. ACE2 and TMPRSS2 immunolocalization and oral manifestations of COVID-19. Park GC, et al. Oral Dis, 2022 Nov. PMID 35000261
  3. Expression of ACE2 and TMPRSS2 Proteins in the Upper and Lower Aerodigestive Tracts of Rats: Implications on COVID 19 Infections. Sato T, et al. Laryngoscope, 2021 Mar. PMID 32940922
  4. The androgen-regulated type II serine protease TMPRSS2 is differentially expressed and mislocalized in prostate adenocarcinoma. Lucas JM, et al. J Pathol, 2008 Jun. PMID 18338334
  5. TMPRSS2 Contributes to Virus Spread and Immunopathology in the Airways of Murine Models after Coronavirus Infection. Iwata-Yoshikawa N, et al. J Virol, 2019 Mar 15. PMID 30626688, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ACE2 and TMPRSS2 immunolocalization and oral manifestations of COVID-19.
    Title: ACE2 and TMPRSS2 immunolocalization and oral manifestations of COVID-19.
  2. Obesogenic and Ketogenic Diets Distinctly Regulate the SARS-CoV-2 Entry Proteins ACE2 and TMPRSS2 and the Renin-Angiotensin System in Rat Lung and Heart Tissues.
    Title: Obesogenic and Ketogenic Diets Distinctly Regulate the SARS-CoV-2 Entry Proteins ACE2 and TMPRSS2 and the Renin-Angiotensin System in Rat Lung and Heart Tissues.
  3. Pulmonary, cardiac and renal distribution of ACE2, furin, TMPRSS2 and ADAM17 in rats with heart failure: Potential implication for COVID-19 disease.
    Title: Pulmonary, cardiac and renal distribution of ACE2, furin, TMPRSS2 and ADAM17 in rats with heart failure: Potential implication for COVID-19 disease.
  4. Expression of ACE2 and TMPRSS2 Proteins in the Upper and Lower Aerodigestive Tracts of Rats: Implications on COVID 19 Infections.
    Title: Expression of ACE2 and TMPRSS2 Proteins in the Upper and Lower Aerodigestive Tracts of Rats: Implications on COVID 19 Infections.
  5. Six differentially expressed genes (Kcne1, Rcan1, Mx1, Mx2, Tmprss2, and RGD1559516) were identified in the renal cortex, and three genes (Rcan1, Mx2, and Tmprss2) were identified in the renal medulla.
    Title: [Differentially expressed genes in the locus associated with relative kidney weight and resting blood pressure in hypertensive rats of the ISIAH strain].
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein autoprocessing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
transmembrane protease serine 2
Names
transmembrane protease, serine 2
NP_569108.2
XP_008766769.1
XP_008766770.1
XP_063126320.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130424.3 → NP_569108.2  transmembrane protease serine 2

    See identical proteins and their annotated locations for NP_569108.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    F7EQ71, Q6P7D7, Q920K3
    Related
    ENSRNOP00000062828.1, ENSRNOT00000066413.5
    Conserved Domains (4) summary
    smart00020
    Location:253 → 482
    Tryp_SPc; Trypsin-like serine protease
    cd00112
    Location:112 → 147
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:254 → 485
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam15494
    Location:152 → 247
    SRCR_2; Scavenger receptor cysteine-rich domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    50403707..50443224 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008768547.4 → XP_008766769.1  transmembrane protease serine 2 isoform X1

    See identical proteins and their annotated locations for XP_008766769.1

    UniProtKB/TrEMBL
    Q920K3
    Conserved Domains (4) summary
    smart00020
    Location:253 → 482
    Tryp_SPc; Trypsin-like serine protease
    cd00112
    Location:112 → 147
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:254 → 485
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam15494
    Location:152 → 247
    SRCR_2; Scavenger receptor cysteine-rich domain

  2. XM_008768548.4 → XP_008766770.1  transmembrane protease serine 2 isoform X1

    See identical proteins and their annotated locations for XP_008766770.1

    UniProtKB/TrEMBL
    Q920K3
    Conserved Domains (4) summary
    smart00020
    Location:253 → 482
    Tryp_SPc; Trypsin-like serine protease
    cd00112
    Location:112 → 147
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:254 → 485
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam15494
    Location:152 → 247
    SRCR_2; Scavenger receptor cysteine-rich domain

  3. XM_063270250.1 → XP_063126320.1  transmembrane protease serine 2 isoform X2

    UniProtKB/TrEMBL
    F7EQ71, Q6P7D7, Q920K3
Nucleotide Protein Strain
Heading Accession and Version

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