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Ggt7 gamma-glutamyltransferase 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 156275, updated on 9-Dec-2024

Summary

Official Symbol
Ggt7provided by RGD
Official Full Name
gamma-glutamyltransferase 7provided by RGD
Primary source
RGD:619870
See related
EnsemblRapid:ENSRNOG00000018441 AllianceGenome:RGD:619870
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ggtl3
Summary
Predicted to enable glutathione hydrolase activity. Predicted to be involved in glutathione catabolic process and negative regulation of response to oxidative stress. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human GGT7 (gamma-glutamyltransferase 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Brain (RPKM 72.4), Thymus (RPKM 8.6) and 3 other tissues See more
Orthologs
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Genomic context

See Ggt7 in Genome Data Viewer
Location:
3q42
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (164438240..164464059, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (143978073..144004597, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (151005960..151029941, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene nuclear receptor coactivator 6 Neighboring gene U1 spliceosomal RNA Neighboring gene small nucleolar RNA SNORA18 Neighboring gene acyl-CoA synthetase short-chain family member 2 Neighboring gene glutathione synthetase Neighboring gene myosin heavy chain 7B

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables glutathione hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glutathione hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables leukotriene C4 gamma-glutamyl transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in glutathione biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in glutathione catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glutathione catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glutathione hydrolase 7
Names
GGT 7
gamma-glutamyltransferase-like 3
gamma-glutamyltranspeptidase 7
NP_569107.2
XP_008760522.1
XP_038960082.1
XP_038960083.1
XP_038960084.1
XP_038960085.1
XP_038960086.1
XP_038960087.1
XP_038960088.1
XP_038960090.1
XP_063139093.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130423.2NP_569107.2  glutathione hydrolase 7

    See identical proteins and their annotated locations for NP_569107.2

    Status: VALIDATED

    Source sequence(s)
    AA925130, AF244973, CB761916
    UniProtKB/Swiss-Prot
    Q99MZ4
    UniProtKB/TrEMBL
    A6KI39, A6KI40
    Related
    ENSRNOP00000025315.4, ENSRNOT00000025315.7
    Conserved Domains (1) summary
    pfam01019
    Location:155653
    G_glu_transpept; Gamma-glutamyltranspeptidase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    164438240..164464059 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104160.2XP_038960088.1  glutathione hydrolase 7 isoform X9

    UniProtKB/TrEMBL
    A6KI39
    Conserved Domains (1) summary
    pfam01019
    Location:79589
    G_glu_transpept; Gamma-glutamyltranspeptidase
  2. XM_039104156.2XP_038960084.1  glutathione hydrolase 7 isoform X3

    UniProtKB/TrEMBL
    A0A8I6A1D7, A6KI39
    Related
    ENSRNOP00000085996.1, ENSRNOT00000103394.2
    Conserved Domains (1) summary
    pfam01019
    Location:155660
    G_glu_transpept; Gamma-glutamyltranspeptidase
  3. XM_039104154.2XP_038960082.1  glutathione hydrolase 7 isoform X1

    UniProtKB/TrEMBL
    A6KI39
    Conserved Domains (1) summary
    pfam01019
    Location:155665
    G_glu_transpept; Gamma-glutamyltranspeptidase
  4. XM_039104158.2XP_038960086.1  glutathione hydrolase 7 isoform X6

    UniProtKB/Swiss-Prot
    Q99MZ4
    UniProtKB/TrEMBL
    A6KI39, A6KI40
    Conserved Domains (1) summary
    pfam01019
    Location:155653
    G_glu_transpept; Gamma-glutamyltranspeptidase
  5. XM_008762300.4XP_008760522.1  glutathione hydrolase 7 isoform X4

    UniProtKB/TrEMBL
    A6KI39
    Related
    ENSRNOP00000101168.1, ENSRNOT00000161417.1
    Conserved Domains (1) summary
    pfam01019
    Location:155658
    G_glu_transpept; Gamma-glutamyltranspeptidase
  6. XM_039104157.2XP_038960085.1  glutathione hydrolase 7 isoform X5

    UniProtKB/TrEMBL
    A6KI39
    Conserved Domains (1) summary
    pfam01019
    Location:155657
    G_glu_transpept; Gamma-glutamyltranspeptidase
  7. XM_039104155.2XP_038960083.1  glutathione hydrolase 7 isoform X2

    UniProtKB/TrEMBL
    A6KI39
    Conserved Domains (1) summary
    pfam01019
    Location:155662
    G_glu_transpept; Gamma-glutamyltranspeptidase
  8. XM_063283023.1XP_063139093.1  glutathione hydrolase 7 isoform X8

    UniProtKB/TrEMBL
    A0A8I5ZYT2
    Related
    ENSRNOP00000084236.2, ENSRNOT00000110295.2
  9. XM_039104159.2XP_038960087.1  glutathione hydrolase 7 isoform X7

    UniProtKB/TrEMBL
    A6KI39
    Conserved Domains (1) summary
    pfam01019
    Location:100610
    G_glu_transpept; Gamma-glutamyltranspeptidase
  10. XM_039104162.2XP_038960090.1  glutathione hydrolase 7 isoform X10

    Conserved Domains (1) summary
    cl19223
    Location:1424
    G_glu_transpept; Gamma-glutamyltranspeptidase