Format

Send to:

Choose Destination

CYP2C18 cytochrome P450 family 2 subfamily C member 18 [ Homo sapiens (human) ]

Gene ID: 1562, updated on 22-Aug-2020

Summary

Official Symbol
CYP2C18provided by HGNC
Official Full Name
cytochrome P450 family 2 subfamily C member 18provided by HGNC
Primary source
HGNC:HGNC:2620
See related
Ensembl:ENSG00000108242 MIM:601131
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPCI; CYP2C; CYP2C17; P450IIC17; P450-6B/29C
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP2C17 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in liver (RPKM 50.3), duodenum (RPKM 49.6) and 5 other tissues See more
Orthologs

Genomic context

See CYP2C18 in Genome Data Viewer
Location:
10q23.33
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (94683729..94736190)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (96443251..96495947)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene helicase, lymphoid specific Neighboring gene CTBP2 pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 9306 Neighboring gene CYP2C19 promoter Neighboring gene cytochrome P450 family 2 subfamily C member 19

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study of acenocoumarol maintenance dosage.
GeneReviews: Not available
Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy.
GeneReviews: Not available
Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686I24235

Gene Ontology Provided by GOA

Function Evidence Code Pubs
arachidonic acid epoxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
aromatase activity IEA
Inferred from Electronic Annotation
more info
 
heme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
monooxygenase activity TAS
Traceable Author Statement
more info
PubMed 
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxygen binding TAS
Traceable Author Statement
more info
PubMed 
retinoic acid 4-hydroxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
steroid hydroxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
epoxygenase P450 pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
exogenous drug catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
organic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidation-reduction process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
retinoic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cytochrome P450 2C18
Names
(S)-mephenytoin hydroxylase associated cytochrome P450
CYPIIC18
cytochrome P450, family 2, subfamily C, polypeptide 18
cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 17
cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 18
cytochrome P450-6B/29C
flavoprotein-linked monooxygenase
microsomal monooxygenase
unspecific monooxygenase
NP_000763.1
NP_001122397.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008373.1 RefSeqGene

    Range
    5236..57697
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000772.3NP_000763.1  cytochrome P450 2C18 isoform 1 precursor

    See identical proteins and their annotated locations for NP_000763.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BX538127, M61853, M61856
    Consensus CDS
    CCDS7435.1
    UniProtKB/Swiss-Prot
    P33260
    UniProtKB/TrEMBL
    Q7Z348
    Related
    ENSP00000285979.6, ENST00000285979.11
    Conserved Domains (1) summary
    pfam00067
    Location:30487
    p450; Cytochrome P450
  2. NM_001128925.2NP_001122397.1  cytochrome P450 2C18 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001122397.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a coding exon in the middle region, but the reading frame is not affected, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    BC096260, BJ993698, BX538127, M61853, M61856
    Consensus CDS
    CCDS44460.1
    UniProtKB/Swiss-Prot
    P33260
    UniProtKB/TrEMBL
    Q7Z348
    Related
    ENSP00000341293.5, ENST00000339022.6
    Conserved Domains (1) summary
    pfam00067
    Location:30428
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    94683729..94736190
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center