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vpu Vpu [ Human immunodeficiency virus 1 ]

Gene ID: 155945, updated on 6-Oct-2023

Summary

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Gene symbol
vpu
Gene description
Vpu
Locus tag
HIV1gp7
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Human immunodeficiency virus 1
Lineage
Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; Lentivirus; Primate lentivirus group
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Genomic context

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Sequence:
NC_001802.1 (5608..5856)

NC_001802.1Genomic Context describing neighboring genes Neighboring gene Gag-Pol Neighboring gene Pr55(Gag) Neighboring gene Vif Neighboring gene Vpr Neighboring gene Tat Neighboring gene Rev Neighboring gene Envelope surface glycoprotein gp160, precursor Neighboring gene Asp Neighboring gene Nef

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001802.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Novel Vpu Adaptive Mutation of HIV-1 Degrades Tetherin in Northern Pig-Tailed Macaques (Macaca leonina) Mainly via the Ubiquitin-Proteasome Pathway and Increases Viral Release. Lu Y, et al. J Virol, 2023 Apr 27. PMID 36971578, Free PMC Article
  2. Insights into the oligomeric structure of the HIV-1 Vpu protein. Majeed S, et al. J Struct Biol, 2023 Mar. PMID 36796461, Free PMC Article
  3. Role of Viral Protein U (Vpu) in HIV-1 Infection and Pathogenesis. Khan N, et al. Viruses, 2021 Jul 27. PMID 34452331, Free PMC Article
  4. Conditional activation of an HIV-1 protease attenuated mutant by a leucine zipper dimerization motif. Yu FH, et al. Virus Res, 2021 Apr 2. PMID 33316353
  5. Large-Scale Arrayed Analysis of Protein Degradation Reveals Cellular Targets for HIV-1 Vpu. Jain P, et al. Cell Rep, 2018 Feb 27. PMID 29490283, Free PMC Article

See all (385) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HIV-1 Vpu protein forms stable oligomers in aqueous solution via its transmembrane domain self-association.
    Title: HIV-1 Vpu protein forms stable oligomers in aqueous solution via its transmembrane domain self-association.
  2. A Novel Vpu Adaptive Mutation of HIV-1 Degrades Tetherin in Northern Pig-Tailed Macaques (Macaca leonina) Mainly via the Ubiquitin-Proteasome Pathway and Increases Viral Release.
    Title: A Novel Vpu Adaptive Mutation of HIV-1 Degrades Tetherin in Northern Pig-Tailed Macaques (Macaca leonina) Mainly via the Ubiquitin-Proteasome Pathway and Increases Viral Release.
  3. Insights into the oligomeric structure of the HIV-1 Vpu protein.
    Title: Insights into the oligomeric structure of the HIV-1 Vpu protein.
  4. Host KIR/HLA-C Genotypes Determine HIV-Mediated Changes of the NK Cell Repertoire and Are Associated With Vpu Sequence Variations Impacting Downmodulation of HLA-C.
    Title: Host KIR/HLA-C Genotypes Determine HIV-Mediated Changes of the NK Cell Repertoire and Are Associated With Vpu Sequence Variations Impacting Downmodulation of HLA-C.
  5. Conditional activation of an HIV-1 protease attenuated mutant by a leucine zipper dimerization motif.
    Title: Conditional activation of an HIV-1 protease attenuated mutant by a leucine zipper dimerization motif.
  6. Role of Viral Protein U (Vpu) in HIV-1 Infection and Pathogenesis.
    Title: Role of Viral Protein U (Vpu) in HIV-1 Infection and Pathogenesis.
  7. HIV-1 Vpu Promotes Phagocytosis of Infected CD4(+) T Cells by Macrophages through Downregulation of CD47.
    Title: HIV-1 Vpu Promotes Phagocytosis of Infected CD4(+) T Cells by Macrophages through Downregulation of CD47.
  8. The viral protein U (Vpu)-interacting host protein ATP6V0C down-regulates cell-surface expression of tetherin and thereby contributes to HIV-1 release.
    Title: The viral protein U (Vpu)-interacting host protein ATP6V0C down-regulates cell-surface expression of tetherin and thereby contributes to HIV-1 release.
  9. Differential Vpu-Mediated CD4 and Tetherin Downregulation Functions among Major HIV-1 Group M Subtypes.
    Title: Differential Vpu-Mediated CD4 and Tetherin Downregulation Functions among Major HIV-1 Group M Subtypes.
  10. HIV-1 Vpu Downregulates Tim-3 from the Surface of Infected CD4(+) T Cells.
    Title: HIV-1 Vpu Downregulates Tim-3 from the Surface of Infected CD4(+) T Cells.
Submit: New GeneRIF Correction See all GeneRIFs (162)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
fatty acid CoA ligase Acsl3 ACSL3 interacts with PubMed
AP-1 complex subunit beta-1 isoform a AP1B1 binds PubMed
AP-1 complex subunit gamma-1 isoform b AP1G1 interacts with PubMed
AP1G1 interacts with PubMed
AP-1 complex subunit mu-1 isoform 2 AP1M1 interacts with PubMed
AP1M1 binds PubMed
AP-1 complex subunit sigma-1A AP1S1 interacts with PubMed
AP1S1 binds PubMed
AP-2 complex subunit alpha-1 isoform 1 AP2A1 interacts with PubMed
AP-2 complex subunit mu isoform a AP2M1 interacts with PubMed
AP2M1 interacts with PubMed
DNA dC->dU-editing enzyme APOBEC-3F isoform a APOBEC3F inhibits PubMed
DNA dC->dU-editing enzyme APOBEC-3G isoform 1 APOBEC3G inhibits PubMed
apolipoprotein L1 isoform a precursor APOL1 downregulated by PubMed
brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform 1 ARFGEF1 interacts with PubMed
brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform 1 ARFGEF2 interacts with PubMed
ATPase family AAA domain-containing protein 3A isoform 1 ATAD3A interacts with PubMed
ATPase family AAA domain-containing protein 3B isoform AAA-TOB3l ATAD3B interacts with PubMed
cyclic AMP-dependent transcription factor ATF-4 ATF4 stabilizes PubMed
plasma membrane calcium-transporting ATPase 1 isoform 1b ATP2B1 interacts with PubMed
ATP synthase subunit beta, mitochondrial precursor ATP5F1B interacts with PubMed
ATP synthase subunit delta, mitochondrial precursor ATP5F1D interacts with PubMed
ATP synthase F(0) complex subunit B1, mitochondrial precursor ATP5PB interacts with PubMed
ATP synthase subunit d, mitochondrial isoform a ATP5PD interacts with PubMed
ATP synthase-coupling factor 6, mitochondrial isoform a precursor ATP5PF interacts with PubMed
ATP synthase subunit O, mitochondrial precursor ATP5PO interacts with PubMed
ataxin-10 isoform 1 ATXN10 interacts with PubMed
aurora kinase A isoform 1 AURKA binds PubMed
beta-2-microglobulin precursor B2M downregulates PubMed
apoptosis regulator BAX isoform beta BAX upregulates PubMed
bcl-2-related protein A1 isoform 1 BCL2A1 downregulates PubMed
bcl-2-like protein 1 isoform Bcl-X(L) BCL2L1 downregulates PubMed
bone marrow stromal antigen 2 precursor BST2 increases PubMed
BST2 downregulates PubMed
BST2 inhibits PubMed
BST2 interacts with PubMed
BST2 downregulates PubMed
BST2 downregulates PubMed
BST2 downregulates PubMed
BST2 counteracts PubMed
BST2 downregulates PubMed
BST2 requires PubMed
BST2 relocalizes PubMed
BST2 requires PubMed
BST2 antagonizes PubMed
BST2 downregulates PubMed
BST2 downregulates PubMed
BST2 co-localizes with PubMed
BST2 disrupts PubMed
BST2 interacts with PubMed
BST2 downregulates PubMed
BST2 stabilizes PubMed
BST2 interacts with PubMed
BST2 inhibits PubMed
BST2 inhibits PubMed
BST2 inhibited by PubMed
BST2 downregulates PubMed
BST2 degrades PubMed
BST2 downregulates PubMed
BST2 inhibits PubMed
BST2 relocalizes PubMed
BST2 downregulates PubMed
BST2 inhibits PubMed
BST2 interacts with PubMed
BST2 downregulates PubMed
BST2 relocalizes PubMed
BST2 downregulates PubMed
BST2 interacts with PubMed
BST2 downregulates PubMed
BST2 binds PubMed
BST2 inhibits PubMed
BST2 interacts with PubMed
BST2 inhibited by PubMed
BST2 interacts with PubMed
BST2 downregulates PubMed
BST2 inhibits PubMed
BST2 inhibits PubMed
BST2 interacts with PubMed
BST2 relocalizes PubMed
BST2 inhibits PubMed
BST2 downregulates PubMed
BST2 inhibits PubMed
BST2 downregulates PubMed
BST2 interacts with PubMed
BST2 interacts with PubMed
BST2 interacts with PubMed
BST2 interacts with PubMed
BST2 interacts with PubMed
BST2 downregulates PubMed
BST2 downregulates PubMed
BST2 downregulates PubMed
BST2 inhibits PubMed
BST2 inhibits PubMed
BST2 downregulates PubMed
BST2 degrades PubMed
BST2 degrades PubMed
BST2 induces ubiquitination of PubMed
BST2 downregulates PubMed
BST2 downregulates PubMed
BST2 interacts with PubMed
BST2 downregulates PubMed
BST2 downregulates PubMed
BST2 inhibits PubMed
BST2 relocalizes PubMed
BST2 induces ubiquitination of PubMed
BST2 interacts with PubMed
BST2 inhibits PubMed
BST2 inhibits PubMed
BST2 interacts with PubMed
BST2 modulates PubMed
BST2 inhibits PubMed
BST2 binds PubMed
BST2 downregulates PubMed
BST2 downregulates PubMed
BST2 downregulates PubMed
BST2 downregulates PubMed
BST2 inhibits PubMed
BST2 downregulates PubMed
BST2 interacts with PubMed
BST2 inhibits PubMed
BST2 interacts with PubMed
BST2 modulates PubMed
BST2 degrades PubMed
BST2 interacts with PubMed
BST2 downregulates PubMed
BST2 interacts with PubMed
BST2 downregulates PubMed
BST2 interacts with PubMed
BST2 downregulates PubMed
BST2 interacts with PubMed
BST2 downregulates PubMed
BST2 downregulates PubMed
BST2 downregulates PubMed
BST2 downregulates PubMed
BST2 disrupts PubMed
BST2 binds PubMed
BST2 downregulates PubMed
F-box/WD repeat-containing protein 1A isoform 2 BTRC requires PubMed
BTRC interacts with PubMed
BTRC interacts with PubMed
BTRC recruits PubMed
BTRC binds PubMed
BTRC binds PubMed
BTRC binds PubMed
BTRC interacts with PubMed
BTRC interacts with PubMed
BTRC interacts with PubMed
BTRC competes with PubMed
BTRC interacts with PubMed
BTRC interacts with PubMed
BTRC inhibits PubMed
BTRC interacts with PubMed
BTRC interacts with PubMed
BTRC inhibits PubMed
caspase-3 isoform a preproprotein CASP3 cooperates with PubMed
CASP3 activates PubMed
caspase-8 isoform 1 precursor CASP8 cooperates with PubMed
eotaxin precursor CCL11 downregulates PubMed
C-C motif chemokine 19 precursor CCL19 inhibits PubMed
CCL19 inhibits PubMed
C-C chemokine receptor type 7 isoform a precursor CCR7 downregulates PubMed
CCR7 downregulates PubMed
CCR7 downregulates PubMed
CCR7 downregulates PubMed
CCR7 co-localizes with PubMed
CD109 antigen isoform 1 preproprotein CD109 downregulates PubMed
sialomucin core protein 24 isoform 1 precursor CD164 downregulates PubMed
T-cell surface glycoprotein CD1c precursor CD1C downregulates PubMed
antigen-presenting glycoprotein CD1d isoform 1 precursor CD1D downregulates PubMed
CD1D downregulates PubMed
CD1D downregulates PubMed
CD1D downregulates PubMed
CD1D inhibits PubMed
T-cell surface glycoprotein CD3 zeta chain isoform 1 precursor CD247 interacts with PubMed
CD27 antigen precursor CD27 downregulates PubMed
leukocyte antigen CD37 isoform A CD37 relocalizes PubMed
CD37 downregulates PubMed
T-cell surface glycoprotein CD3 delta chain isoform A precursor CD3D interacts with PubMed
T-cell surface glycoprotein CD3 epsilon chain precursor CD3E antagonizes PubMed
CD3E interacts with PubMed
T-cell surface glycoprotein CD3 gamma chain precursor CD3G interacts with PubMed
T-cell surface glycoprotein CD4 isoform 1 precursor CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 degrades PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 depends on PubMed
CD4 interacts with PubMed
CD4 downregulates PubMed
CD4 degrades PubMed
CD4 interacts with PubMed
CD4 relocalizes PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 interacts with PubMed
CD4 inhibited by PubMed
CD4 regulates PubMed
CD4 binds PubMed
CD4 interacts with PubMed
CD4 interacts with PubMed
CD4 induces accumulation of PubMed
CD4 interacts with PubMed
CD4 downregulates PubMed
CD4 binds PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 degrades PubMed
tumor necrosis factor receptor superfamily member 5 isoform 1 precursor CD40 upregulates PubMed
CD48 antigen isoform 1 precursor CD48 downregulates PubMed
leukocyte surface antigen CD53 isoform 1 CD53 relocalizes PubMed
CD53 downregulates PubMed
CD63 antigen isoform A CD63 downregulates PubMed
T-cell antigen CD7 precursor CD7 downregulates PubMed
HLA class II histocompatibility antigen gamma chain isoform b CD74 interacts with PubMed
CD81 antigen isoform 1 CD81 co-localizes with PubMed
CD81 downregulates PubMed
CD82 antigen isoform 1 CD82 downregulates PubMed
CD83 antigen isoform a precursor CD83 downregulates PubMed
M-phase inducer phosphatase 1 isoform a CDC25A stabilizes PubMed
cadherin-1 isoform 1 preproprotein CDH1 interacts with PubMed
centrosomal protein of 57 kDa isoform a CEP57 interacts with PubMed
ceramide synthase 2 CERS2 interacts with PubMed
cysteine and histidine-rich domain-containing protein 1 isoform a CHORDC1 interacts with PubMed
contactin-associated protein 1 precursor CNTNAP1 interacts with PubMed
collagen alpha-1(I) chain preproprotein COL1A1 upregulates PubMed
casein kinase I isoform gamma-3 isoform 1 CSNK1G3 binds PubMed
casein kinase II subunit alpha isoform a CSNK2A1 phosphorylated by PubMed
CSNK2A1 phosphorylated by PubMed
casein kinase II subunit alpha' CSNK2A2 phosphorylated by PubMed
CSNK2A2 phosphorylated by PubMed
casein kinase II subunit beta isoform 1 CSNK2B phosphorylated by PubMed
CSNK2B phosphorylated by PubMed
CSNK2B phosphorylated by PubMed
catenin beta-1 isoform 1 CTNNB1 stabilizes PubMed
CTNNB1 interacts with PubMed
CTNNB1 stabilizes PubMed
cullin-1 CUL1 interacts with PubMed
C-X-C chemokine receptor type 3 isoform 1 CXCR3 downregulates PubMed
C-X-C chemokine receptor type 4 isoform b CXCR4 downregulates PubMed
diacylglycerol lipase-beta isoform 1 DAGLB interacts with PubMed
dynamin-2 isoform 3 DNM2 inhibited by PubMed
enhancer of mRNA-decapping protein 4 isoform 2 EDC4 interacts with PubMed
early endosome antigen 1 EEA1 co-localizes with PubMed
interferon-induced, double-stranded RNA-activated protein kinase isoform a EIF2AK2 inhibits PubMed
tumor necrosis factor receptor superfamily member 6 isoform 1 precursor FAS interacts with PubMed
F-box/WD repeat-containing protein 11 isoform A FBXW11 interacts with PubMed
FBXW11 interacts with PubMed
low affinity immunoglobulin gamma Fc region receptor III-A isoform a FCGR3A interacts with PubMed
FCGR3A antagonizes PubMed
flotillin-1 isoform 1 FLOT1 co-localizes with PubMed
protein c-Fos FOS activates PubMed
protein FosB isoform 1 FOSB activates PubMed
guanylate-binding protein 5 isoform 1 GBP5 antagonizes PubMed
golgin subfamily A member 4 isoform 2 GOLGA4 co-localizes with PubMed
glycogen synthase kinase-3 beta isoform 1 GSK3B binds PubMed
glycophorin-A isoform 1 precursor GYPA downregulates PubMed
trifunctional enzyme subunit alpha, mitochondrial precursor HADHA interacts with PubMed
trifunctional enzyme subunit beta, mitochondrial isoform 1 precursor HADHB interacts with PubMed
hepatocyte growth factor isoform 1 preproprotein HGF downregulates PubMed
hepatocyte growth factor-regulated tyrosine kinase substrate HGS interacts with PubMed
HGS requires PubMed
HGS cooperates with PubMed
HGS interacts with PubMed
HLA class I histocompatibility antigen, A alpha chain isoform A*03:01:01:01 precursor HLA-A downregulates PubMed
HLA-A regulated by PubMed
major histocompatibility complex, class I, B precursor HLA-B downregulates PubMed
HLA-B regulated by PubMed
HLA class I histocompatibility antigen, C alpha chain precursor HLA-C downregulates PubMed
HLA-C regulated by PubMed
HLA class II histocompatibility antigen, DM alpha chain precursor HLA-DMA modulates PubMed
HLA class II histocompatibility antigen, DM beta chain precursor HLA-DMB modulates PubMed
HLA class II histocompatibility antigen, DO alpha chain precursor HLA-DOA modulates PubMed
HLA class II histocompatibility antigen, DO beta chain precursor HLA-DOB modulates PubMed
HLA class II histocompatibility antigen, DP alpha 1 chain precursor HLA-DPA1 modulates PubMed
HLA class II histocompatibility antigen, DP beta 1 chain precursor HLA-DPB1 modulates PubMed
HLA class II histocompatibility antigen, DQ alpha 1 chain precursor HLA-DQA1 modulates PubMed
HLA class II histocompatibility antigen, DQ alpha 2 chain precursor HLA-DQA2 modulates PubMed
HLA class II histocompatibility antigen, DQ beta 1 chain isoform 1 precursor HLA-DQB1 modulates PubMed
HLA class II histocompatibility antigen, DQ beta 2 chain isoform 2 precursor HLA-DQB2 modulates PubMed
HLA class II histocompatibility antigen, DR alpha chain precursor HLA-DRA modulates PubMed
major histocompatibility complex, class II, DR beta 1 precursor HLA-DRB1 modulates PubMed
major histocompatibility complex, class II, DR beta 3 precursor HLA-DRB3 modulates PubMed
major histocompatibility complex, class II, DR beta 4 precursor HLA-DRB4 modulates PubMed
major histocompatibility complex, class II, DR beta 5 precursor HLA-DRB5 modulates PubMed
HLA class I histocompatibility antigen, alpha chain E precursor HLA-E regulated by PubMed
HLA class I histocompatibility antigen, alpha chain F isoform 2 precursor HLA-F regulated by PubMed
HLA class I histocompatibility antigen, alpha chain G isoform 2 precursor HLA-G regulated by PubMed
very-long-chain 3-oxoacyl-CoA reductase HSD17B12 interacts with PubMed
intercellular adhesion molecule 1 precursor ICAM1 downregulates PubMed
intercellular adhesion molecule 2 precursor ICAM2 downregulates PubMed
ICAM2 interacts with PubMed
gamma-interferon-inducible protein 16 isoform 1 IFI16 antagonizes PubMed
interferon-induced protein 44-like isoform 1 IFI44L downregulates PubMed
interferon-induced protein with tetratricopeptide repeats 1 isoform 1 IFIT1 inhibits PubMed
interferon-induced protein with tetratricopeptide repeats 2 IFIT2 inhibits PubMed
interferon-induced protein with tetratricopeptide repeats 3 isoform a IFIT3 inhibits PubMed
interferon-induced transmembrane protein 1 IFITM1 inhibits PubMed
interferon alpha-1/13 precursor IFNA1 suppresses PubMed
IFNA1 attenuates PubMed
IFNA1 modulates PubMed
IFNA1 disrupts PubMed
IFNA1 inhibited by PubMed
IFNA1 interacts with PubMed
IFNA1 inhibits PubMed
interferon alpha-10 precursor IFNA10 interacts with PubMed
IFNA10 inhibits PubMed
IFNA13 interacts with PubMed
IFNA13 inhibits PubMed
interferon alpha-14 precursor IFNA14 interacts with PubMed
IFNA14 inhibits PubMed
interferon alpha-16 precursor IFNA16 interacts with PubMed
IFNA16 inhibits PubMed
interferon alpha-17 precursor IFNA17 interacts with PubMed
IFNA17 inhibits PubMed
interferon alpha-2 precursor IFNA2 interacts with PubMed
IFNA2 inhibits PubMed
interferon alpha-21 precursor IFNA21 interacts with PubMed
IFNA21 inhibits PubMed
interferon alpha-4 precursor IFNA4 interacts with PubMed
IFNA4 inhibits PubMed
interferon alpha-5 precursor IFNA5 interacts with PubMed
IFNA5 inhibits PubMed
interferon alpha-6 precursor IFNA6 interacts with PubMed
IFNA6 inhibits PubMed
interferon alpha-7 precursor IFNA7 interacts with PubMed
IFNA7 inhibits PubMed
interferon alpha-8 precursor IFNA8 interacts with PubMed
IFNA8 inhibits PubMed
interferon beta precursor IFNB1 inhibits PubMed
IFNB1 suppresses PubMed
IFNB1 modulates PubMed
IFNB1 attenuates PubMed
IFNB1 modulates PubMed
IFNB1 inhibited by PubMed
interferon gamma receptor 1 isoform 1 precursor IFNGR1 modulates PubMed
IFNGR1 downregulates PubMed
insulin-like growth factor-binding protein 1 precursor IGFBP1 downregulates PubMed
insulin-like growth factor-binding protein 2 isoform a precursor IGFBP2 downregulates PubMed
inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1 IKBKB inhibits PubMed
cytokine receptor common subunit gamma precursor IL2RG downregulates PubMed
importin-9 IPO9 interacts with PubMed
interferon regulatory factor 3 isoform 1 IRF3 induces cleavage of PubMed
IRF3 induces cleavage of PubMed
IRF3 induces cleavage of PubMed
IRF3 induces cleavage of PubMed
IRF3 co-localizes with PubMed
IRF3 interacts with PubMed
IRF3 complexes with PubMed
ubiquitin-like protein ISG15 ISG15 inhibits PubMed
interferon-stimulated gene 20 kDa protein isoform a ISG20 inhibits PubMed
transcription factor Jun JUN activates PubMed
transcription factor JunB JUNB activates PubMed
transcription factor JunD isoform JunD-FL JUND activates PubMed
potassium channel subfamily K member 3 KCNK3 interacts with PubMed
KCNK3 interacts with PubMed
killer cell immunoglobulin-like receptor 2DL2 precursor KIR2DL2 inhibits PubMed
NKG2-D type II integral membrane protein KLRK1 downregulates PubMed
lysosome-associated membrane glycoprotein 1 precursor LAMP1 downregulates PubMed
LAMP1 co-localizes with PubMed
lysosome-associated membrane glycoprotein 2 isoform A precursor LAMP2 downregulates PubMed
LAMP2 co-localizes with PubMed
tyrosine-protein kinase Lck isoform a LCK relocalizes PubMed
leukocyte immunoglobulin-like receptor subfamily A member 4 precursor LILRA4 requires PubMed
leucine-rich PPR motif-containing protein, mitochondrial precursor LRPPRC interacts with PubMed
mitochondrial antiviral-signaling protein isoform 2 MAVS degrades PubMed
MAVS blocks PubMed
MHC class I polypeptide-related sequence A isoform 1 (MICA*001) precursor MICA downregulates PubMed
macrophage migration inhibitory factor MIF inhibited by PubMed
72 kDa type IV collagenase isoform 1 preproprotein MMP2 upregulates PubMed
moesin MSN interacts with PubMed
mucin-1 isoform 1 precursor MUC1 downregulates PubMed
interferon-induced GTP-binding protein Mx1 isoform a MX1 inhibits PubMed
NEDD8-activating enzyme E1 regulatory subunit isoform b NAE1 depends on PubMed
condensin-2 complex subunit D3 isoform 1 NCAPD3 interacts with PubMed
NEDD8 NEDD8 interacts with PubMed
nuclear factor of activated T-cells 5 isoform c NFAT5 regulates PubMed
nuclear factor of activated T-cells, cytoplasmic 1 isoform B NFATC1 regulates PubMed
nuclear factor of activated T-cells, cytoplasmic 2 isoform B NFATC2 regulates PubMed
nuclear factor of activated T-cells, cytoplasmic 3 isoform 2 NFATC3 regulates PubMed
nuclear factor of activated T-cells, cytoplasmic 4 isoform 2 NFATC4 regulates PubMed
nuclear factor NF-kappa-B p105 subunit isoform 1 NFKB1 modulates PubMed
NFKB1 inhibits PubMed
NFKB1 inhibits PubMed
NFKB1 inhibits PubMed
NFKB1 inhibits PubMed
NFKB1 inhibits PubMed
NF-kappa-B inhibitor alpha NFKBIA inhibits PubMed
NFKBIA inhibits PubMed
NFKBIA stabilizes PubMed
NFKBIA stabilizes PubMed
serine/threonine-protein kinase NLK NLK binds PubMed
nuclear protein localization protein 4 homolog isoform 1 NPLOC4 cooperates with PubMed
2'-5'-oligoadenylate synthase 1 isoform 3 OAS1 antagonizes PubMed
poly PARP1 induces cleavage of PubMed
type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform 2 PIP4P1 interacts with PubMed
serine/threonine-protein kinase N2 isoform 1 PKN2 binds PubMed
serine/threonine-protein kinase PLK1 PLK1 binds PubMed
serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform 1 PPP2CA dephosphorylated by PubMed
serine/threonine-protein phosphatase 2A catalytic subunit beta isoform PPP2CB dephosphorylated by PubMed
serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform 1 PPP2R1A dephosphorylated by PubMed
serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform a PPP2R5E interacts with PubMed
prolactin regulatory element-binding protein isoform 1 PREB interacts with PubMed
DNA-dependent protein kinase catalytic subunit isoform 1 PRKDC interacts with PubMed
prostaglandin E synthase 3 isoform a PTGES3 interacts with PubMed
poliovirus receptor isoform alpha precursor PVR downregulates PubMed
PVR relocalizes PubMed
PVR downregulates PubMed
PVR downregulates PubMed
UL-16 binding protein 5 preproprotein RAET1G downregulates PubMed
UL16-binding protein 6 precursor RAET1L downregulates PubMed
ran-specific GTPase-activating protein isoform 2 RANBP1 interacts with PubMed
RNA-binding motif protein, Y chromosome, family 1 member A1 isoform 1 RBMY1A1 interacts with PubMed
transcription factor p65 isoform 1 RELA inhibits PubMed
RELA inhibited by PubMed
E3 ubiquitin-protein ligase RNF115 RNF115 inhibits PubMed
E3 ubiquitin-protein ligase RNF213 isoform 2 RNF213 interacts with PubMed
ribosomal protein S6 kinase alpha-5 isoform a RPS6KA5 binds PubMed
S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 isoform 1 RSAD2 inhibits PubMed
reticulon-3 isoform a RTN3 interacts with PubMed
reticulon-4 isoform C RTN4 interacts with PubMed
secretory carrier-associated membrane protein 3 isoform 1 SCAMP3 interacts with PubMed
SCY1-like protein 2 isoform 1 SCYL2 inhibited by PubMed
SCYL2 inhibited by PubMed
SCYL2 inhibited by PubMed
SCYL2 binds PubMed
L-selectin precursor SELL inhibits PubMed
SELL downregulates PubMed
P-selectin glycoprotein ligand 1 isoform 2 precursor SELPLG downregulates PubMed
semaphorin-4D isoform 1 precursor SEMA4D downregulates PubMed
semaphorin-7A isoform 1 preproprotein SEMA7A downregulates PubMed
sphingosine-1-phosphate lyase 1 SGPL1 interacts with PubMed
small glutamine-rich tetratricopeptide repeat-containing protein alpha SGTA interacts with PubMed
SGTA binds PubMed
SGTA interacts with PubMed
S-phase kinase-associated protein 1 isoform a SKP1 interacts with PubMed
SLAM family member 6 isoform 2 precursor SLAMF6 downregulates PubMed
SLAMF6 downregulates PubMed
SLAMF6 downregulates PubMed
SLAMF6 modulates PubMed
SLAMF6 modulates PubMed
SLAMF6 downregulates PubMed
SLAMF6 interacts with PubMed
SLAMF6 binds PubMed
long-chain fatty acid transport protein 4 SLC27A4 interacts with PubMed
sodium-coupled neutral amino acid symporter 1 isoform 1 SLC38A1 degrades PubMed
SLC38A1 ubiquitinates PubMed
SLC38A1 binds PubMed
SLC38A1 depletes PubMed
SLC38A1 downregulates PubMed
SRA stem-loop-interacting RNA-binding protein, mitochondrial isoform 1 precursor SLIRP interacts with PubMed
survival motor neuron protein isoform d SMN1 upregulates PubMed
zinc finger protein SNAI1 SNAI1 upregulates PubMed
SNAI1 upregulates PubMed
zinc finger protein SNAI2 SNAI2 upregulates PubMed
SNAI2 upregulates PubMed
clathrin coat assembly protein AP180 isoform a SNAP91 inhibited by PubMed
leukosialin precursor SPN antagonizes PubMed
serine/arginine-rich splicing factor 5 isoform 1 SRSF5 regulated by PubMed
signal transducer and activator of transcription 1-alpha/beta isoform alpha STAT1 inhibits PubMed
TBC1 domain family member 15 isoform 1 TBC1D15 interacts with PubMed
FAST kinase domain-containing protein 4 isoform 1 TBRG4 interacts with PubMed
transferrin receptor protein 1 isoform 1 TFRC downregulates PubMed
TFRC co-localizes with PubMed
transforming growth factor beta-1 proprotein preproprotein TGFB1 interacts with PubMed
TGFB1 activates PubMed
transforming growth factor beta-2 proprotein isoform 2 preproprotein TGFB2 interacts with PubMed
TGFB2 activates PubMed
transforming growth factor beta-3 proprotein isoform 1 preproprotein TGFB3 interacts with PubMed
TGFB3 activates PubMed
TGF-beta receptor type-1 isoform 1 precursor TGFBR1 interacts with PubMed
TGF-beta receptor type-2 isoform B precursor TGFBR2 interacts with PubMed
transforming growth factor beta receptor type 3 isoform a precursor TGFBR3 interacts with PubMed
trans-Golgi network integral membrane protein 2 isoform 1 precursor TGOLN2 co-localizes with PubMed
TGOLN2 co-localizes with PubMed
transmembrane protein 192 TMEM192 interacts with PubMed
tumor necrosis factor TNF inhibits PubMed
tumor necrosis factor receptor superfamily member 1B precursor TNFRSF1B downregulates PubMed
tumor necrosis factor receptor superfamily member 8 isoform 1 precursor TNFRSF8 downregulates PubMed
cellular tumor antigen p53 isoform a TP53 upregulates PubMed
TP53 stabilizes PubMed
TNF receptor-associated factor 1 isoform a TRAF1 downregulates PubMed
tripartite motif-containing protein 5 isoform alpha TRIM5 inhibits PubMed
tumor susceptibility gene 101 protein TSG101 requires PubMed
tetraspanin-7 TSPAN7 downregulates PubMed
testis-specific serine/threonine-protein kinase 2 TSSK2 binds PubMed
ubiquitin-associated protein 1 isoform 1 UBAP1 requires PubMed
UBAP1 requires PubMed
ubiquitin recognition factor in ER-associated degradation protein 1 isoform A UFD1 cooperates with PubMed
UL16-binding protein 2 preproprotein ULBP2 downregulates PubMed
uroporphyrinogen decarboxylase UROD upregulates PubMed
vascular cell adhesion protein 1 isoform a precursor VCAM1 upregulates PubMed
transitional endoplasmic reticulum ATPase isoform 1 VCP cooperates with PubMed
VCP cooperates with PubMed
vascular endothelial growth factor A, long form isoform b VEGFA upregulates PubMed
vacuolar protein sorting-associated protein 4A VPS4A cooperates with PubMed
vacuolar protein sorting-associated protein 4B VPS4B cooperates with PubMed
WD repeat-containing protein 81 isoform 1 WDR81 requires PubMed
exportin-1 isoform 1 XPO1 interacts with PubMed
exportin-4 isoform 1 XPO4 interacts with PubMed
exportin-5 XPO5 interacts with PubMed

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General protein information

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Preferred Names
Vpu
NP_057855.1
  • Vpu and gp160 are translated from different reading frames of the same bicistronic mRNA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001802.1 Reference assembly

    Range
    5608..5856
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_057855.1 Vpu [Human immunodeficiency virus 1]

    See identical proteins and their annotated locations for NP_057855.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P05919, P05920, P05922, P69699, P69700, Q9WB91
    UniProtKB/TrEMBL
    Q74598, Q76PP7
    Conserved Domains (1) summary
    pfam00558
    Location:23 → 79
    Vpu; Vpu protein
Nucleotide Protein
Heading Accession and Version

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