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Lcp2 lymphocyte cytosolic protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 155918, updated on 12-Jan-2022

Summary

Official Symbol
Lcp2provided by RGD
Official Full Name
lymphocyte cytosolic protein 2provided by RGD
Primary source
RGD:619743
See related
Ensembl:ENSRNOG00000005620
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Slp76
Summary
Predicted to be involved in cell surface receptor signaling pathway; intracellular signal transduction; and positive regulation of protein kinase activity. Predicted to act upstream of or within mast cell activation. Predicted to be located in cell-cell junction; cytosol; and plasma membrane raft. Predicted to be part of TCR signalosome. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human LCP2 (lymphocyte cytosolic protein 2). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Thymus (RPKM 212.4), Spleen (RPKM 146.1) and 7 other tissues See more
Orthologs
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Genomic context

See Lcp2 in Genome Data Viewer
Location:
10q12
Exon count:
21
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (18642600..18689562)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (18996523..19043289)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel interacting protein 1 Neighboring gene uncharacterized LOC120095245 Neighboring gene potassium calcium-activated channel subfamily M regulatory beta subunit 1 Neighboring gene chromosome 10 open reading frame, human C5orf58 Neighboring gene forkhead box I1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within mast cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of TCR signalosome ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane raft ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
lymphocyte cytosolic protein 2
Names
lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76kD)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130421.2NP_569105.1  lymphocyte cytosolic protein 2

    See identical proteins and their annotated locations for NP_569105.1

    Status: PROVISIONAL

    Source sequence(s)
    BC100066
    UniProtKB/TrEMBL
    Q920L0
    Related
    ENSRNOP00000050879.5, ENSRNOT00000046135.5
    Conserved Domains (3) summary
    cd09522
    Location:1078
    SAM_SLP76; SAM domain of SLP76 subfamily
    smart00454
    Location:1270
    SAM; Sterile alpha motif
    cd09929
    Location:402523
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    18642600..18689562
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085104.1XP_038941032.1  lymphocyte cytosolic protein 2 isoform X1

    Conserved Domains (3) summary
    cd09522
    Location:1078
    SAM_SLP76; SAM domain of SLP76 subfamily
    cd09929
    Location:408529
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
    PHA03247
    Location:130415
    PHA03247; large tegument protein UL36; Provisional
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