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Hyal1 hyaluronoglucosaminidase 1 [ Mus musculus (house mouse) ]

Gene ID: 15586, updated on 16-Oct-2021

Summary

Official Symbol
Hyal1provided by MGI
Official Full Name
hyaluronoglucosaminidase 1provided by MGI
Primary source
MGI:MGI:96298
See related
Ensembl:ENSMUSG00000010051
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fus2; Hya1; Nat6; Hyal-1
Expression
Broad expression in liver adult (RPKM 16.1), lung adult (RPKM 10.4) and 22 other tissues See more
Orthologs
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Genomic context

See Hyal1 in Genome Data Viewer
Location:
9 F1; 9 58.17 cM
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (107454149..107458898)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (107576950..107581699)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (107479283..107482468)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene 9917 Neighboring gene tumor suppressor 2, mitochondrial calcium regulator Neighboring gene hyaluronoglucosaminidase 2 Neighboring gene N(alpha)-acetyltransferase 80, NatH catalytic subunit Neighboring gene hyaluronoglucosaminidase 3 Neighboring gene interferon-related developmental regulator 2 Neighboring gene leucine-rich single-pass membrane protein 2 Neighboring gene sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Potential readthrough

Included gene: Naa80

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables hyaluronan synthase activity ISO
Inferred from Sequence Orthology
more info
 
enables hyalurononglucosaminidase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
 
NOT enables virus receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to UV-B ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to fibroblast growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to pH ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to platelet-derived growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic skeletal joint morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hyaluronan biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in hyaluronan catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in hyaluronan catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in hyaluronan metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of growth ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of hyaluranon cable assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in response to antibiotic ISO
Inferred from Sequence Orthology
more info
 
involved_in response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
 
involved_in response to virus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in hyaluranon cable ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
hyaluronidase-1
Names
N-acetyltransferase 6
Protein fus-2
Protein fusion-2
NP_001318090.2
NP_032343.3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001331161.2NP_001318090.2  hyaluronidase-1 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR compared to variant 1. The encoded isoform (2) has a shorter, distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL672219
    Related
    ENSMUSP00000108006.3, ENSMUST00000112387.9
    Conserved Domains (1) summary
    pfam01630
    Location:41366
    Glyco_hydro_56; Hyaluronidase
  2. NM_008317.6NP_032343.3  hyaluronidase-1 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL672219
    Consensus CDS
    CCDS23497.1
    Related
    ENSMUSP00000010195.8, ENSMUST00000010195.14
    Conserved Domains (1) summary
    pfam01630
    Location:41366
    Glyco_hydro_56; Hyaluronidase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    107454149..107458898
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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