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Hyal1 hyaluronoglucosaminidase 1 [ Mus musculus (house mouse) ]

Gene ID: 15586, updated on 2-Oct-2018

Summary

Official Symbol
Hyal1provided by MGI
Official Full Name
hyaluronoglucosaminidase 1provided by MGI
Primary source
MGI:MGI:96298
See related
Ensembl:ENSMUSG00000010051 Vega:OTTMUSG00000028838
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fus2; Hya1; Nat6; Hyal-1
Expression
Broad expression in liver adult (RPKM 16.1), lung adult (RPKM 10.4) and 22 other tissues See more
Orthologs

Genomic context

See Hyal1 in Genome Data Viewer
Location:
9 F1; 9 58.17 cM
Exon count:
4
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (107576952..107580137)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (107479283..107482468)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene tumor suppressor 2, mitochondrial calcium regulator Neighboring gene hyaluronoglucosaminidase 2 Neighboring gene N(alpha)-acetyltransferase 80, NatH catalytic subunit Neighboring gene hyaluronoglucosaminidase 3 Neighboring gene interferon-related developmental regulator 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Potential readthrough

Included gene: Naa80

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
hyaluronan synthase activity ISO
Inferred from Sequence Orthology
more info
 
hyalurononglucosaminidase activity ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
NOT virus receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
cellular response to UV-B ISO
Inferred from Sequence Orthology
more info
 
cellular response to fibroblast growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
 
cellular response to pH ISO
Inferred from Sequence Orthology
more info
 
cellular response to platelet-derived growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
embryonic skeletal joint morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
hyaluronan biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
hyaluronan catabolic process ISO
Inferred from Sequence Orthology
more info
 
hyaluronan metabolic process ISO
Inferred from Sequence Orthology
more info
 
inflammatory response ISO
Inferred from Sequence Orthology
more info
 
metabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
positive regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of growth ISO
Inferred from Sequence Orthology
more info
 
positive regulation of hyaluranon cable assembly ISO
Inferred from Sequence Orthology
more info
 
response to antibiotic ISO
Inferred from Sequence Orthology
more info
 
response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
 
response to virus IDA
Inferred from Direct Assay
more info
PubMed 
response to virus ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
hyaluranon cable ISO
Inferred from Sequence Orthology
more info
 
lysosome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
hyaluronidase-1
Names
N-acetyltransferase 6
Protein fus-2
Protein fusion-2
NP_032343.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001331161.1NP_001318090.1  hyaluronidase-1 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR compared to variant 1. The encoded isoform (2) has a shorter, distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK028942, AL672219
    UniProtKB/Swiss-Prot
    Q91ZJ9
  2. NM_008317.5NP_032343.2  hyaluronidase-1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_032343.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL672219
    Consensus CDS
    CCDS23497.1
    UniProtKB/Swiss-Prot
    Q91ZJ9
    Related
    ENSMUSP00000010195.7, OTTMUSP00000036591, ENSMUST00000010195.13, OTTMUST00000071415
    Conserved Domains (1) summary
    pfam01630
    Location:54379
    Glyco_hydro_56; Hyaluronidase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

    Range
    107576952..107580137
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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