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CYP2C8 cytochrome P450 family 2 subfamily C member 8 [ Homo sapiens (human) ]

Gene ID: 1558, updated on 12-Jan-2019

Summary

Official Symbol
CYP2C8provided by HGNC
Official Full Name
cytochrome P450 family 2 subfamily C member 8provided by HGNC
Primary source
HGNC:HGNC:2622
See related
Ensembl:ENSG00000138115 MIM:601129
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPC8; CYPIIC8; CYP2C8DM; MP-12/MP-20
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Expression
Restricted expression toward liver (RPKM 350.3) See more
Orthologs

Genomic context

See CYP2C8 in Genome Data Viewer
Location:
10q23.33
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (95036772..95069497, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (96796529..96829255, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 2 subfamily C member 59, pseudogene Neighboring gene cytochrome P450 family 2 subfamily C member 60, pseudogene Neighboring gene CYP2C8 promoter Neighboring gene -8 kb enhancer of CYP2C8 Neighboring gene uncharacterized LOC107984258

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
DRUG METABOLISM, ALTERED, CYP2C8-RELATED
MedGen: C4693948 OMIM: 618018 GeneReviews: Not available
not available
Pioglitazone response
MedGen: CN427422 GeneReviews: Not available
Compare labs
Rosiglitazone response
MedGen: CN427421 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites.
NHGRI GWA Catalog
Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy.
NHGRI GWA Catalog
Bisphosphonate-related osteonecrosis of the jaw is associated with polymorphisms of the cytochrome P450 CYP2C8 in multiple myeloma: a genome-wide single nucleotide polymorphism analysis.
NHGRI GWA Catalog
Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study.
NHGRI GWA Catalog
Genome-wide association study of ancestry-specific TB risk in the South African Coloured population.
NHGRI GWA Catalog
Genome-wide association study of antibody response to smallpox vaccine.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of cytochrome P450, family 2, subfamily C, polypeptide 8 (CYP2C8) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
arachidonic acid epoxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
aromatase activity IEA
Inferred from Electronic Annotation
more info
 
caffeine oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
estrogen 16-alpha-hydroxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
heme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
monooxygenase activity TAS
Traceable Author Statement
more info
 
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
steroid hydroxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
drug metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
epoxygenase P450 pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
epoxygenase P450 pathway TAS
Traceable Author Statement
more info
 
exogenous drug catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
exogenous drug catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
lipid hydroxylation IDA
Inferred from Direct Assay
more info
PubMed 
long-chain fatty acid biosynthetic process TAS
Traceable Author Statement
more info
 
omega-hydroxylase P450 pathway TAS
Traceable Author Statement
more info
 
organic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
organic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidation-reduction process IDA
Inferred from Direct Assay
more info
PubMed 
oxidative demethylation IDA
Inferred from Direct Assay
more info
PubMed 
steroid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
organelle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cytochrome P450 2C8
Names
P450 form 1
cytochrome P450 IIC2
cytochrome P450 MP-12
cytochrome P450 MP-20
cytochrome P450 form 1
cytochrome P450, family 2, subfamily C, polypeptide 8
cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8
flavoprotein-linked monooxygenase
microsomal monooxygenase
s-mephenytoin 4-hydroxylase
xenobiotic monooxygenase
NP_000761.3
NP_001185782.1
NP_001185783.1
NP_001185784.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007972.1 RefSeqGene

    Range
    5001..37726
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000770.3NP_000761.3  cytochrome P450 2C8 isoform a precursor

    See identical proteins and their annotated locations for NP_000761.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    BC020596, M21941, Y00498
    Consensus CDS
    CCDS7438.1
    UniProtKB/Swiss-Prot
    P10632
    Related
    ENSP00000360317.3, ENST00000371270.5
    Conserved Domains (1) summary
    pfam00067
    Location:30487
    p450; Cytochrome P450
  2. NM_001198853.1NP_001185782.1  cytochrome P450 2C8 isoform b

    See identical proteins and their annotated locations for NP_001185782.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 4 both encode the same isoform (b).
    Source sequence(s)
    AK293327, M21941
    Consensus CDS
    CCDS73166.1
    UniProtKB/Swiss-Prot
    P10632
    UniProtKB/TrEMBL
    B7Z1F5
    Related
    ENSP00000485110.1, ENST00000623108.3
    Conserved Domains (1) summary
    pfam00067
    Location:3417
    p450; Cytochrome P450
  3. NM_001198854.1NP_001185783.1  cytochrome P450 2C8 isoform c

    See identical proteins and their annotated locations for NP_001185783.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AK293327, AK293328, M21941
    Consensus CDS
    CCDS55721.1
    UniProtKB/Swiss-Prot
    P10632
    UniProtKB/TrEMBL
    B7Z1F5
    Related
    ENSP00000445062.1, ENST00000535898.5
    Conserved Domains (1) summary
    pfam00067
    Location:5385
    p450; Cytochrome P450
  4. NM_001198855.1NP_001185784.1  cytochrome P450 2C8 isoform b

    See identical proteins and their annotated locations for NP_001185784.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 4 both encode the same isoform (b).
    Source sequence(s)
    AK293327, CD014119, M21941
    Consensus CDS
    CCDS73166.1
    UniProtKB/Swiss-Prot
    P10632
    UniProtKB/TrEMBL
    B7Z1F5
    Related
    ENSP00000442343.2, ENST00000539050.5
    Conserved Domains (1) summary
    pfam00067
    Location:3417
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

    Range
    95036772..95069497 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_030878.1: Suppressed sequence

    Description
    NM_030878.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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