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Elavl4 ELAV like RNA binding protein 4 [ Mus musculus (house mouse) ]

Gene ID: 15572, updated on 7-Feb-2023

Summary

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Official Symbol
Elavl4provided by MGI
Official Full Name
ELAV like RNA binding protein 4provided by MGI
Primary source
MGI:MGI:107427
See related
Ensembl:ENSMUSG00000028546 AllianceGenome:MGI:107427
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hud; Elav; PNEM
Summary
Enables mRNA binding activity. Acts upstream of or within learning; locomotory behavior; and neuron differentiation. Located in axon; cytoplasm; and dendrite. Is expressed in several structures, including central nervous system; enteric nervous system; genitourinary system; intestine; and sensory organ. Orthologous to human ELAVL4 (ELAV like RNA binding protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E14 (RPKM 18.2), whole brain E14.5 (RPKM 17.9) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Elavl4 in Genome Data Viewer
Location:
4 C7; 4 51.42 cM
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (110060934..110209145, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (110203737..110351939, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene doublesex and mab-3 related transcription factor like family A2, opposite strand Neighboring gene doublesex and mab-3 related transcription factor like family A2 Neighboring gene predicted gene, 33070 Neighboring gene predicted gene, 54251 Neighboring gene ATP/GTP binding protein-like 4 Neighboring gene predicted gene 12807 Neighboring gene microfibrillar-associated protein 1B pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RNA binding protein HuD mediates the crosstalk between β cells and islet endothelial cells by the regulation of Endostatin and Serpin E1 expression. Jung M, et al. Cell Death Dis, 2022 Dec 5. PMID 36470872, Free PMC Article
  2. Loss of RNA binding protein HuD facilitates the production of the senescence-associated secretory phenotype. Ryu S, et al. Cell Death Dis, 2022 Apr 11. PMID 35411051, Free PMC Article
  3. The RNA-Binding Protein HuD Regulates Alternative Splicing and Alternative Polyadenylation in the Mouse Neocortex. Sena RM, et al. Molecules, 2021 May 11. PMID 34064652, Free PMC Article
  4. Overexpression of neuronal RNA-binding protein HuD increases reward induced reinstatement of an instrumental response. Oliver RJ, et al. Neurosci Lett, 2018 Sep 14. PMID 29940328, Free PMC Article
  5. Alternative role of HuD splicing variants in neuronal differentiation. Hayashi S, et al. J Neurosci Res, 2015 Mar. PMID 25332105

See all (212) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNA binding protein HuD mediates the crosstalk between beta cells and islet endothelial cells by the regulation of Endostatin and Serpin E1 expression.
    Title: RNA binding protein HuD mediates the crosstalk between β cells and islet endothelial cells by the regulation of Endostatin and Serpin E1 expression.
  2. Loss of RNA binding protein HuD facilitates the production of the senescence-associated secretory phenotype.
    Title: Loss of RNA binding protein HuD facilitates the production of the senescence-associated secretory phenotype.
  3. ALS-related FUS mutations alter axon growth in motoneurons and affect HuD/ELAVL4 and FMRP activity.
    Title: ALS-related FUS mutations alter axon growth in motoneurons and affect HuD/ELAVL4 and FMRP activity.
  4. RNA binding protein HuD contributes to beta-cell dysfunction by impairing mitochondria dynamics.
    Title: RNA binding protein HuD contributes to β-cell dysfunction by impairing mitochondria dynamics.
  5. The RNA-Binding Protein HuD Regulates Alternative Splicing and Alternative Polyadenylation in the Mouse Neocortex.
    Title: The RNA-Binding Protein HuD Regulates Alternative Splicing and Alternative Polyadenylation in the Mouse Neocortex.
  6. The RNA-binding protein, HuD regulates proglucagon biosynthesis in pancreatic alpha cells.
    Title: The RNA-binding protein, HuD regulates proglucagon biosynthesis in pancreatic α cells.
  7. RNA-seq analysis of mouse neocortical polysomes demonstrated that the translation of distinct mRNA isoforms of the RNA binding protein (RBP), Elavl4, in radial glia progenitors and early neurons depends on its alternative 5' UTRs. 5' UTR-driven Elavl4 isoform-specific translation depends on upstream control by another RBP, Celf1. Celf1 regulation of Elavl4 translation dictates development of glutamatergic neurons.
    Title: Translational derepression of Elavl4 isoforms at their alternative 5' UTRs determines neuronal development.
  8. HuD and miR-203a cooperatively regulate INSM1 expression.
    Title: RNA binding protein HuD and microRNA-203a cooperatively regulate insulinoma-associated 1 mRNA.
  9. HuD enhanced p27 mRNA translation by interacting with both the 5'-untranslated region (UTR) and the 3'-UTR of p27 mRNA, and consequently suppressed cell cycle progression and growth of pancreatic neuroendocrine tumors.
    Title: Reduced expression of the RNA-binding protein HuD in pancreatic neuroendocrine tumors correlates with low p27(Kip1) levels and poor prognosis.
  10. we demonstrated HuD downregulation and HuB upregulation in DRG sensory neurons induced by diabetes, which might be correlated with altered post-transcriptional control of RNAs involved in the regulation of thermal hypoalgesia condition caused by the advanced diabetic neuropathy.
    Title: RNA-Binding Proteins HuB, HuC, and HuD are Distinctly Regulated in Dorsal Root Ganglia Neurons from STZ-Sensitive Compared to STZ-Resistant Diabetic Mice.
Submit: New GeneRIF Correction See all GeneRIFs (37)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR AU-rich region binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(A) binding ISO
Inferred from Sequence Orthology
more info
  
enables pre-mRNA intronic pyrimidine-rich binding ISO
Inferred from Sequence Orthology
more info
  
enables translation regulator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in 3'-UTR-mediated mRNA stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA processing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cerebral cortex neuron differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of 3'-UTR-mediated mRNA stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of dendrite development ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mRNA stability ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of translation at postsynapse ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in growth cone ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in polysomal ribosome ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ELAV-like protein 4
Names
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
HU-antigen D
RNA-binding protein HUD3
paraneoplastic encephalomyelitis antigen HuD

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038698.1 → NP_001033787.1  ELAV-like protein 4 isoform b

    See identical proteins and their annotated locations for NP_001033787.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AL627206, AL627425, BC052451, CN663544
    Consensus CDS
    CCDS18470.1
    UniProtKB/TrEMBL
    A0A6P5PM46, A0A8C6GXW1, Q8BVA9
    Related
    ENSMUSP00000099784.5, ENSMUST00000102723.11
    Conserved Domains (1) summary
    TIGR01661
    Location:43 → 379
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  2. NM_001163397.1 → NP_001156869.1  ELAV-like protein 4 isoform c

    See identical proteins and their annotated locations for NP_001156869.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and lacks an alternate in-frame segment compared to variant 1. The resulting isoform (c) has a distinct N-terminus and is shorter compared to isoform a.
    Source sequence(s)
    AK014133, AL627206, AL627425, CF726962
    Consensus CDS
    CCDS51262.1
    UniProtKB/TrEMBL
    A0A8C6MTZ9, A2A9S3, Q9CXQ0
    Related
    ENSMUSP00000102214.3, ENSMUST00000106603.9
    Conserved Domains (1) summary
    TIGR01661
    Location:46 → 355
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  3. NM_001163399.1 → NP_001156871.1  ELAV-like protein 4 isoform d

    See identical proteins and their annotated locations for NP_001156871.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (d) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AK014133, AL627206, BB648788, BC048159
    Consensus CDS
    CCDS51261.1
    UniProtKB/TrEMBL
    A0A6P5PG97, A2A9R6, Q80XH9, Q9CXQ0
    Related
    ENSMUSP00000099783.3, ENSMUST00000102722.9
    Conserved Domains (1) summary
    TIGR01661
    Location:48 → 370
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  4. NM_001347178.1 → NP_001334107.1  ELAV-like protein 4 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (e) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AL627206, AL627425
    Consensus CDS
    CCDS84777.1
    UniProtKB/TrEMBL
    A0A6P5PS72, A2A9R8
    Related
    ENSMUSP00000102208.2, ENSMUST00000106598.8
    Conserved Domains (1) summary
    TIGR01661
    Location:43 → 365
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  5. NM_001357190.1 → NP_001344119.1  ELAV-like protein 4 isoform f

    Status: VALIDATED

    Source sequence(s)
    AK014133, AL627206, AL627425, BB648788, BC048159
    UniProtKB/TrEMBL
    A0A8C6GWW3
    Conserved Domains (1) summary
    TIGR01661
    Location:41 → 363
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  6. NM_010488.4 → NP_034618.2  ELAV-like protein 4 isoform a

    See identical proteins and their annotated locations for NP_034618.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AL627206, AL627425, BB648788, BC048159
    Consensus CDS
    CCDS18471.1
    UniProtKB/Swiss-Prot
    Q61701, Q8BVA9
    UniProtKB/TrEMBL
    A0A6P5PNN5, A0A8C6GW46, Q80XH9
    Related
    ENSMUSP00000102207.4, ENSMUST00000106597.10
    Conserved Domains (1) summary
    TIGR01661
    Location:48 → 384
    ELAV_HUD_SF; ELAV/HuD family splicing factor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    110060934..110209145 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253254.2 → XP_030109114.1  ELAV-like protein 4 isoform X18

    Conserved Domains (1) summary
    TIGR01661
    Location:46 → 368
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  2. XM_006502798.4 → XP_006502861.1  ELAV-like protein 4 isoform X6

    See identical proteins and their annotated locations for XP_006502861.1

    UniProtKB/TrEMBL
    A0A6P7R046, A0A8C6GVY6
    Conserved Domains (1) summary
    TIGR01661
    Location:46 → 382
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  3. XM_030253257.2 → XP_030109117.1  ELAV-like protein 4 isoform X21

    UniProtKB/TrEMBL
    A0A8C6GXP3
    Related
    ENSMUSP00000102212.2, ENSMUST00000106601.8
    Conserved Domains (1) summary
    TIGR01661
    Location:43 → 365
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  4. XM_006502800.4 → XP_006502863.1  ELAV-like protein 4 isoform X9

    See identical proteins and their annotated locations for XP_006502863.1

    Conserved Domains (1) summary
    TIGR01661
    Location:43 → 379
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  5. XM_030253255.2 → XP_030109115.1  ELAV-like protein 4 isoform X19

    Conserved Domains (1) summary
    TIGR01661
    Location:58 → 367
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  6. XM_006502794.5 → XP_006502857.1  ELAV-like protein 4 isoform X2

    Conserved Domains (1) summary
    TIGR01661
    Location:58 → 394
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  7. XM_030253258.1 → XP_030109118.1  ELAV-like protein 4 isoform X22

    Conserved Domains (1) summary
    TIGR01661
    Location:56 → 365
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  8. XM_030253249.1 → XP_030109109.1  ELAV-like protein 4 isoform X11

    Conserved Domains (1) summary
    TIGR01661
    Location:56 → 378
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  9. XM_006502795.3 → XP_006502858.1  ELAV-like protein 4 isoform X3

    See identical proteins and their annotated locations for XP_006502858.1

    UniProtKB/TrEMBL
    A0A6P7QTU4, A0A8C6GWP4
    Conserved Domains (1) summary
    TIGR01661
    Location:56 → 392
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  10. XM_006502803.5 → XP_006502866.1  ELAV-like protein 4 isoform X17

    Conserved Domains (1) summary
    TIGR01661
    Location:60 → 369
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  11. XM_006502799.5 → XP_006502862.1  ELAV-like protein 4 isoform X7

    See identical proteins and their annotated locations for XP_006502862.1

    UniProtKB/TrEMBL
    A2A9S0
    Related
    ENSMUSP00000102210.3, ENSMUST00000106600.9
    Conserved Domains (1) summary
    TIGR01661
    Location:60 → 382
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  12. XM_006502793.5 → XP_006502856.1  ELAV-like protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C6GXT8
    Conserved Domains (1) summary
    TIGR01661
    Location:60 → 396
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  13. XM_006502802.4 → XP_006502865.1  ELAV-like protein 4 isoform X13

    See identical proteins and their annotated locations for XP_006502865.1

    Conserved Domains (1) summary
    TIGR01661
    Location:36 → 372
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  14. XM_030253260.2 → XP_030109120.1  ELAV-like protein 4 isoform X25

    Conserved Domains (1) summary
    TIGR01661
    Location:43 → 352
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  15. XM_036163734.1 → XP_036019627.1  ELAV-like protein 4 isoform X23

    Conserved Domains (1) summary
    TIGR01661
    Location:36 → 358
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  16. XM_036163733.1 → XP_036019626.1  ELAV-like protein 4 isoform X14

    Conserved Domains (1) summary
    TIGR01661
    Location:50 → 372
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  17. XM_030253259.2 → XP_030109119.1  ELAV-like protein 4 isoform X24

    Conserved Domains (1) summary
    TIGR01661
    Location:48 → 357
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  18. XM_036163730.1 → XP_036019623.1  ELAV-like protein 4 isoform X4

    Conserved Domains (1) summary
    TIGR01661
    Location:50 → 386
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  19. XM_006502801.4 → XP_006502864.1  ELAV-like protein 4 isoform X12

    See identical proteins and their annotated locations for XP_006502864.1

    Conserved Domains (1) summary
    TIGR01661
    Location:41 → 377
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  20. XM_030253253.2 → XP_030109113.1  ELAV-like protein 4 isoform X16

    Conserved Domains (1) summary
    TIGR01661
    Location:46 → 369
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  21. XM_030253248.2 → XP_030109108.1  ELAV-like protein 4 isoform X8

    Conserved Domains (1) summary
    TIGR01661
    Location:58 → 381
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  22. XM_036163731.1 → XP_036019624.1  ELAV-like protein 4 isoform X10

    Conserved Domains (1) summary
    TIGR01661
    Location:56 → 379
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  23. XM_006502797.5 → XP_006502860.1  ELAV-like protein 4 isoform X5

    Conserved Domains (1) summary
    TIGR01661
    Location:60 → 383
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  24. XM_030253256.2 → XP_030109116.1  ELAV-like protein 4 isoform X20

    Conserved Domains (1) summary
    TIGR01661
    Location:43 → 366
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  25. XM_030253252.2 → XP_030109112.1  ELAV-like protein 4 isoform X15

    Conserved Domains (1) summary
    TIGR01661
    Location:48 → 371
    ELAV_HUD_SF; ELAV/HuD family splicing factor
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61701.1 GenPept UniProtKB/Swiss-Prot:Q61701

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