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Elavl4 ELAV like RNA binding protein 4 [ Mus musculus (house mouse) ]

Gene ID: 15572, updated on 3-Apr-2024

Summary

Official Symbol
Elavl4provided by MGI
Official Full Name
ELAV like RNA binding protein 4provided by MGI
Primary source
MGI:MGI:107427
See related
Ensembl:ENSMUSG00000028546 AllianceGenome:MGI:107427
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hud; Elav; PNEM
Summary
Enables mRNA binding activity. Acts upstream of or within learning; locomotory behavior; and neuron differentiation. Located in axon; cytoplasm; and dendrite. Is expressed in several structures, including central nervous system; enteric nervous system; genitourinary system; intestine; and sensory organ. Orthologous to human ELAVL4 (ELAV like RNA binding protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E14 (RPKM 18.2), whole brain E14.5 (RPKM 17.9) and 5 other tissues See more
Orthologs
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Genomic context

Location:
4 C7; 4 51.42 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (110060934..110209127, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (110203737..110351939, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene doublesex and mab-3 related transcription factor like family A2, opposite strand Neighboring gene STARR-seq mESC enhancer starr_11077 Neighboring gene doublesex and mab-3 related transcription factor like family A2 Neighboring gene STARR-seq mESC enhancer starr_11078 Neighboring gene STARR-seq mESC enhancer starr_11079 Neighboring gene predicted gene, 33070 Neighboring gene STARR-seq mESC enhancer starr_11080 Neighboring gene STARR-seq mESC enhancer starr_11081 Neighboring gene predicted gene, 54251 Neighboring gene ATP/GTP binding protein-like 4 Neighboring gene STARR-seq mESC enhancer starr_11082 Neighboring gene STARR-seq mESC enhancer starr_11083 Neighboring gene predicted gene 12807 Neighboring gene STARR-seq mESC enhancer starr_11084 Neighboring gene STARR-seq mESC enhancer starr_11085 Neighboring gene STARR-seq mESC enhancer starr_11086 Neighboring gene STARR-seq mESC enhancer starr_11087 Neighboring gene microfibrillar-associated protein 1B pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA 3'-UTR AU-rich region binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables poly(A) binding ISO
Inferred from Sequence Orthology
more info
 
enables pre-mRNA intronic pyrimidine-rich binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in apical dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 
located_in ribosome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ELAV-like protein 4
Names
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
HU-antigen D
RNA-binding protein HUD3
paraneoplastic encephalomyelitis antigen HuD

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038698.2NP_001033787.1  ELAV-like protein 4 isoform b

    See identical proteins and their annotated locations for NP_001033787.1

    Status: VALIDATED

    Source sequence(s)
    AL627206, AL627425
    Consensus CDS
    CCDS18470.1
    UniProtKB/TrEMBL
    Q9CXQ0
    Related
    ENSMUSP00000099784.5, ENSMUST00000102723.11
    Conserved Domains (1) summary
    TIGR01661
    Location:43379
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  2. NM_001163397.2NP_001156869.1  ELAV-like protein 4 isoform c

    See identical proteins and their annotated locations for NP_001156869.1

    Status: VALIDATED

    Source sequence(s)
    AL627206, AL627425
    Consensus CDS
    CCDS51262.1
    UniProtKB/TrEMBL
    Q9CXQ0
    Related
    ENSMUSP00000102214.3, ENSMUST00000106603.9
    Conserved Domains (1) summary
    TIGR01661
    Location:46355
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  3. NM_001163399.2NP_001156871.1  ELAV-like protein 4 isoform d

    See identical proteins and their annotated locations for NP_001156871.1

    Status: VALIDATED

    Source sequence(s)
    AL627206, AL627425
    Consensus CDS
    CCDS51261.1
    UniProtKB/TrEMBL
    Q9CXQ0
    Related
    ENSMUSP00000099783.3, ENSMUST00000102722.9
    Conserved Domains (1) summary
    TIGR01661
    Location:48370
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  4. NM_001347178.1NP_001334107.1  ELAV-like protein 4 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (e) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AL627206, AL627425
    Consensus CDS
    CCDS84777.1
    UniProtKB/TrEMBL
    Q9CXQ0
    Related
    ENSMUSP00000102208.2, ENSMUST00000106598.8
    Conserved Domains (1) summary
    TIGR01661
    Location:43365
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  5. NM_001357190.2NP_001344119.1  ELAV-like protein 4 isoform f

    Status: VALIDATED

    Source sequence(s)
    AL627206, AL627425
    UniProtKB/TrEMBL
    Q9CXQ0
    Conserved Domains (1) summary
    TIGR01661
    Location:41363
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  6. NM_001421151.1NP_001408080.1  ELAV-like protein 4 isoform g

    Status: VALIDATED

    Source sequence(s)
    AL627206, AL627425
  7. NM_001421152.1NP_001408081.1  ELAV-like protein 4 isoform g

    Status: VALIDATED

    Source sequence(s)
    AL627206, AL627425
  8. NM_001421153.1NP_001408082.1  ELAV-like protein 4 isoform e

    Status: VALIDATED

    Source sequence(s)
    AL627206, AL627425
  9. NM_001421154.1NP_001408083.1  ELAV-like protein 4 isoform e

    Status: VALIDATED

    Source sequence(s)
    AL627206, AL627425
  10. NM_001421155.1NP_001408084.1  ELAV-like protein 4 isoform h

    Status: VALIDATED

    Source sequence(s)
    AL627206, AL627425
  11. NM_001421156.1NP_001408085.1  ELAV-like protein 4 isoform i

    Status: VALIDATED

    Source sequence(s)
    AL627206, AL627425
  12. NM_001421157.1NP_001408086.1  ELAV-like protein 4 isoform j

    Status: VALIDATED

    Source sequence(s)
    AL627206, AL627425
  13. NM_001421158.1NP_001408087.1  ELAV-like protein 4 isoform k

    Status: VALIDATED

    Source sequence(s)
    AL627206, AL627425
  14. NM_001421159.1NP_001408088.1  ELAV-like protein 4 isoform m

    Status: VALIDATED

    Source sequence(s)
    AL627206, AL627425
  15. NM_001421160.1NP_001408089.1  ELAV-like protein 4 isoform n

    Status: VALIDATED

    Source sequence(s)
    AL627206, AL627425
  16. NM_001421161.1NP_001408090.1  ELAV-like protein 4 isoform o

    Status: VALIDATED

    Source sequence(s)
    AL627206, AL627425
  17. NM_001421162.1NP_001408091.1  ELAV-like protein 4 isoform p

    Status: VALIDATED

    Source sequence(s)
    AL627206, AL627425
  18. NM_001421163.1NP_001408092.1  ELAV-like protein 4 isoform q

    Status: VALIDATED

    Source sequence(s)
    AL627206, AL627425
  19. NM_001421164.1NP_001408093.1  ELAV-like protein 4 isoform r

    Status: VALIDATED

    Source sequence(s)
    AL627206, AL627425
  20. NM_001421165.1NP_001408094.1  ELAV-like protein 4 isoform s

    Status: VALIDATED

    Source sequence(s)
    AL627206, AL627425
  21. NM_001421166.1NP_001408095.1  ELAV-like protein 4 isoform o

    Status: VALIDATED

    Source sequence(s)
    AL627206, AL627425
  22. NM_001421167.1NP_001408096.1  ELAV-like protein 4 isoform t

    Status: VALIDATED

    Source sequence(s)
    AL627206, AL627425
  23. NM_001421168.1NP_001408097.1  ELAV-like protein 4 isoform u

    Status: VALIDATED

    Source sequence(s)
    AL627206, AL627425
  24. NM_010488.5NP_034618.2  ELAV-like protein 4 isoform a

    See identical proteins and their annotated locations for NP_034618.2

    Status: VALIDATED

    Source sequence(s)
    AL627206, AL627425
    Consensus CDS
    CCDS18471.1
    UniProtKB/Swiss-Prot
    A2A9R6, A2A9R7, A2A9R8, A2A9S0, A2A9S1, A2A9S2, A2A9S3, O55010, Q61701, Q6PHZ3, Q8BVA9
    UniProtKB/TrEMBL
    Q9CXQ0
    Related
    ENSMUSP00000102207.4, ENSMUST00000106597.10
    Conserved Domains (1) summary
    TIGR01661
    Location:48384
    ELAV_HUD_SF; ELAV/HuD family splicing factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    110060934..110209127 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502800.4XP_006502863.1  ELAV-like protein 4 isoform X9

    See identical proteins and their annotated locations for XP_006502863.1

    UniProtKB/TrEMBL
    Q9CXQ0
    Conserved Domains (1) summary
    TIGR01661
    Location:43379
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  2. XM_030253255.2XP_030109115.1  ELAV-like protein 4 isoform X19

    UniProtKB/TrEMBL
    Q9CXQ0
    Conserved Domains (1) summary
    TIGR01661
    Location:58367
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  3. XM_006502794.5XP_006502857.1  ELAV-like protein 4 isoform X2

    UniProtKB/TrEMBL
    Q9CXQ0
    Conserved Domains (1) summary
    TIGR01661
    Location:58394
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  4. XM_006502803.5XP_006502866.1  ELAV-like protein 4 isoform X17

    UniProtKB/TrEMBL
    Q9CXQ0
    Conserved Domains (1) summary
    TIGR01661
    Location:60369
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  5. XM_036163730.1XP_036019623.1  ELAV-like protein 4 isoform X4

    UniProtKB/TrEMBL
    Q9CXQ0
    Conserved Domains (1) summary
    TIGR01661
    Location:50386
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  6. XM_036163731.1XP_036019624.1  ELAV-like protein 4 isoform X10

    UniProtKB/TrEMBL
    Q9CXQ0
    Conserved Domains (1) summary
    TIGR01661
    Location:56379
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  7. XM_006502797.5XP_006502860.1  ELAV-like protein 4 isoform X5

    UniProtKB/TrEMBL
    Q9CXQ0
    Conserved Domains (1) summary
    TIGR01661
    Location:60383
    ELAV_HUD_SF; ELAV/HuD family splicing factor