Htr6 5-hydroxytryptamine (serotonin) receptor 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Htr6provided by MGI
Official Full Name: 5-hydroxytryptamine (serotonin) receptor 6provided by MGI
Primary source: MGI:MGI:1196627
See related: Ensembl:ENSMUSG00000028747 AllianceGenome:MGI:1196627
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5-HT6
Summary: Predicted to enable G protein-coupled serotonin receptor activity and neurotransmitter receptor activity. Involved in cerebral cortex cell migration and positive regulation of TOR signaling. Located in cilium. Is expressed in cerebral cortex intermediate zone; cerebral cortex subventricular zone; and cortical plate. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human HTR6 (5-hydroxytryptamine receptor 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cortex adult (RPKM 1.8), frontal lobe adult (RPKM 1.5) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D3; 4 70.57 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (138787017..138802881, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (139059706..139075570, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HTR6 and SSTR3 ciliary targeting relies on both IC3 loops and C-terminal tails.
Title: HTR6 and SSTR3 ciliary targeting relies on both IC3 loops and C-terminal tails.
Dynamic interactions of the 5-HT6 receptor with protein partners control dendritic tree morphogenesis.
Title: Dynamic interactions of the 5-HT(6) receptor with protein partners control dendritic tree morphogenesis.
Intracellular 5-hydroxytryptamine receptors (5-HT6R) signaling was found to be linked to RhoA GTPase activation and was involved in the maturation of osteoclasts. This signaling pathway also showed enhanced bone destruction after lipopolysaccharide (LPS) administration in mice.
Title: Dysregulation of 5-hydroxytryptamine 6 receptor accelerates maturation of bone-resorbing osteoclasts and induces bone loss.
Results suggest that degeneration of the nigrostriatal pathway causes the decreased dopamine levels in the limbic and limbic related brain regions and the enhanced sensitivity of the 5-HT6 receptor on the glutamate and GABA neurons in the basolateral amygdala, which appear to be an etiologic and pathophysiological factor for anxiety in Parkinson's disease.
Title: Activation and blockade of basolateral amygdala 5-HT(6) receptor produce anxiolytic-like behaviors in an experimental model of Parkinson's disease.
High 5-HT6R expression is associated with delayed bone development and regeneration.
Title: Peripheral serotonin-mediated system suppresses bone development and regeneration via serotonin 6 G-protein-coupled receptor.
This study suggested that 5-HT6 plays a critical role in Alzheimer's disease development through regulating the morphology and function of neuronal primary cilia, which is possibly related to the AIS and axon alterations in Alzheimer's disease development.
Title: Serotonin 5-HT6 receptors affect cognition in a mouse model of Alzheimer's disease by regulating cilia function.
these findings suggest that disrupting 5-HT6 receptor-neurofibromin interaction prevents agonist-independent 5-HT6 receptor-operated cAMP signaling in prefrontal cortex, an effect that might underlie neuronal abnormalities in NF1 patients.
Title: Physical interaction between neurofibromin and serotonin 5-HT6 receptor promotes receptor constitutive activity.
Results implicate a role of 5-HT6 receptor signaling in primary cilia morphology, suggest that 5-HT6 receptor research should consider relative levels of receptor expression when evaluating their impact on primary cilia function.
Title: 5-HT(6) receptor blockade regulates primary cilia morphology in striatal neurons.
5-HT6/7 receptor antagonist ADN-1184 displays anxiolytic-like activity in animal models of anxiety which employed punished stimuli.
Title: ADN-1184, a monoaminergic ligand with 5-HT6/7 receptor antagonist action, exhibits activity in animal models of anxiety.
SNX14 is a dual endogenous negative regulator in 5-HT6R-mediated signaling pathway.
Title: SNX14 is a bifunctional negative regulator for neuronal 5-HT6 receptor signaling.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Htr6 (e-PCR), detects polymorphism
- UniSTS:143430

NoName (e-PCR)
- UniSTS:488266

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled serotonin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled serotonin receptor activity	ISO Inferred from Sequence Orthology more info
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cerebral cortex cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in learning	ISO Inferred from Sequence Orthology more info
involved_in long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of acetylcholine secretion, neurotransmission	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gamma-aminobutyric acid secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glutamate secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TOR signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dopamine secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gamma-aminobutyric acid secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: 5-hydroxytryptamine receptor 6

Names: 5-HT-6; serotonin receptor 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001377096.1 → NP_001364025.1 5-hydroxytryptamine receptor 6

Status: VALIDATED

Source sequence(s)

AL805923

UniProtKB/Swiss-Prot

Q9R1C8

UniProtKB/TrEMBL

Q14AW8

Related

ENSMUSP00000101428.2, ENSMUST00000105802.8

Conserved Domains (1) summary

cd15054
Location:29 → 333

7tmA_5-HT6; serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_021358.2 → NP_067333.1 5-hydroxytryptamine receptor 6

See identical proteins and their annotated locations for NP_067333.1

Status: PROVISIONAL

Source sequence(s)

AL805923

Consensus CDS

CCDS18838.1

UniProtKB/Swiss-Prot

Q9R1C8

UniProtKB/TrEMBL

Q14AW8

Related

ENSMUSP00000068333.2, ENSMUST00000068036.2

Conserved Domains (1) summary

cd15054
Location:29 → 333

7tmA_5-HT6; serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors