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Htr2c 5-hydroxytryptamine (serotonin) receptor 2C [ Mus musculus (house mouse) ]

Gene ID: 15560, updated on 8-Feb-2024

Summary

Official Symbol
Htr2cprovided by MGI
Official Full Name
5-hydroxytryptamine (serotonin) receptor 2Cprovided by MGI
Primary source
MGI:MGI:96281
See related
Ensembl:ENSMUSG00000041380 AllianceGenome:MGI:96281
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SR1; 5HT1c; Htr1c; 5-HT1C; 5-HT2C; 5-HT-1C; 5-HT-2C; 5-HT2cR; 5-HTR2C
Summary
Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in rodents show altered patterns of RNA editing in response to drug treatments and stressful situations. [provided by RefSeq, Jul 2008]
Expression
Biased expression in cerebellum adult (RPKM 5.4), frontal lobe adult (RPKM 3.5) and 4 other tissues See more
Orthologs
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Genomic context

See Htr2c in Genome Data Viewer
Location:
X F2; X 68.46 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (145745509..145980273)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (146962464..147197277)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 18174 Neighboring gene prohibitin pseudogene Neighboring gene small nucleolar RNA, H/ACA box 35 Neighboring gene microRNA 3552 Neighboring gene microRNA 764 Neighboring gene microRNA 1912 Neighboring gene microRNA 1264 Neighboring gene STARR-seq mESC enhancer starr_48056 Neighboring gene microRNA 1298 Neighboring gene microRNA 1911 Neighboring gene microRNA 448 Neighboring gene STARR-seq mESC enhancer starr_48057 Neighboring gene interleukin 13 receptor, alpha 2 Neighboring gene vomeronasal 1 receptor 239, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding ISO
Inferred from Sequence Orthology
more info
 
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G protein-coupled serotonin receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables G protein-coupled serotonin receptor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables Gq/11-coupled serotonin receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serotonin binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in G protein-coupled serotonin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in behavioral fear response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in behavioral response to nicotine ISO
Inferred from Sequence Orthology
more info
 
involved_in cGMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in feeding behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in feeding behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of dopamine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phospholipase C-activating serotonin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phospholipase C-activating serotonin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipase D-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of acetylcholine secretion, neurotransmission ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of calcium-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gamma-aminobutyric acid secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of appetite IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of corticotropin-releasing hormone secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of nervous system process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in release of sequestered calcium ion into cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
 
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of G protein-coupled serotonin receptor complex ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
5-hydroxytryptamine receptor 2C
Names
5-HT2C receptor
5-hydroxytryptamine receptor 1C
serotonin receptor 2C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411391.1NP_001398320.1  5-hydroxytryptamine receptor 2C isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL662932, AL808014, BX005219
    UniProtKB/TrEMBL
    B1ATN4, S4R2T0
    Related
    ENSMUSP00000138772.2, ENSMUST00000156697.8
  2. NM_008312.4NP_032338.3  5-hydroxytryptamine receptor 2C isoform 1 precursor

    See identical proteins and their annotated locations for NP_032338.3

    Status: REVIEWED

    Source sequence(s)
    AK034512, AK079648, BC098327
    Consensus CDS
    CCDS30459.1
    UniProtKB/Swiss-Prot
    B1ATN5, P34968, Q5WRU6
    UniProtKB/TrEMBL
    Q8BZI5
    Related
    ENSMUSP00000043936.3, ENSMUST00000036303.9
    Conserved Domains (1) summary
    cd15305
    Location:55386
    7tmA_5-HT2C; serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    145745509..145980273
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251228.2XP_030107088.1  5-hydroxytryptamine receptor 2C isoform X1

    Conserved Domains (2) summary
    cd14964
    Location:4675
    7tm_GPCRs; TM helix 5 [structural motif]
    cl28897
    Location:17220
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily