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Htr1b 5-hydroxytryptamine (serotonin) receptor 1B [ Mus musculus (house mouse) ]

Gene ID: 15551, updated on 10-Oct-2020

Summary

Official Symbol
Htr1bprovided by MGI
Official Full Name
5-hydroxytryptamine (serotonin) receptor 1Bprovided by MGI
Primary source
MGI:MGI:96274
See related
Ensembl:ENSMUSG00000049511
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5-HT-1B
Orthologs

Genomic context

See Htr1b in Genome Data Viewer
Location:
9 E1; 9 44.61 cM
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (81510344..81515885, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (81628291..81633832, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (81524999..81526159, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39381 Neighboring gene high-mobility group nucleosome binding domain 5 pseudogene Neighboring gene RIKEN cDNA D430036J16 gene Neighboring gene uncharacterized LOC118567673 Neighboring gene SET nuclear oncogene pseudogene Neighboring gene meiotic double-stranded break formation protein 4 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide pseudogene

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • D430036J16Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled serotonin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
G protein-coupled serotonin receptor activity ISO
Inferred from Sequence Orthology
more info
 
drug binding IDA
Inferred from Direct Assay
more info
PubMed 
drug binding ISO
Inferred from Sequence Orthology
more info
 
neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serotonin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serotonin binding IDA
Inferred from Direct Assay
more info
PubMed 
serotonin binding ISO
Inferred from Sequence Orthology
more info
 
voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
G protein-coupled receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
adenylate cyclase-inhibiting serotonin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase-inhibiting serotonin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
behavior IEA
Inferred from Electronic Annotation
more info
 
bone remodeling IGI
Inferred from Genetic Interaction
more info
PubMed 
cellular response to alkaloid ISO
Inferred from Sequence Orthology
more info
 
cellular response to drug ISO
Inferred from Sequence Orthology
more info
 
cellular response to temperature stimulus IDA
Inferred from Direct Assay
more info
PubMed 
chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
drinking behavior ISO
Inferred from Sequence Orthology
more info
 
feeding behavior ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gamma-aminobutyric acid secretion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of serotonin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of synaptic transmission, GABAergic ISO
Inferred from Sequence Orthology
more info
 
negative regulation of synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vascular smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
presynaptic modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
protein kinase C-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of behavior IEA
Inferred from Electronic Annotation
more info
 
regulation of dopamine secretion ISO
Inferred from Sequence Orthology
more info
 
regulation of synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
 
response to cocaine ISO
Inferred from Sequence Orthology
more info
 
response to drug IDA
Inferred from Direct Assay
more info
PubMed 
response to ethanol ISO
Inferred from Sequence Orthology
more info
 
response to toxic substance IDA
Inferred from Direct Assay
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
vasoconstriction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
calyx of Held ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
serotonergic synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
5-hydroxytryptamine receptor 1B
Names
5-HT1B receptor
5-HT<1B> receptor
serotonin receptor 1B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010482.2NP_034612.1  5-hydroxytryptamine receptor 1B

    See identical proteins and their annotated locations for NP_034612.1

    Status: VALIDATED

    Source sequence(s)
    AC158998
    Consensus CDS
    CCDS23370.1
    UniProtKB/Swiss-Prot
    P28334
    UniProtKB/TrEMBL
    Q0VES5
    Related
    ENSMUSP00000139389.1, ENSMUST00000183482.1
    Conserved Domains (1) summary
    cd15333
    Location:42376
    7tmA_5-HT1B_1D; serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    81510344..81515885 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244063.2XP_030099923.1  5-hydroxytryptamine receptor 1B isoform X1

    Related
    ENSMUSP00000050898.4
    Conserved Domains (1) summary
    cd15333
    Location:42376
    7tmA_5-HT1B_1D; serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors
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