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RBM33 RNA binding motif protein 33 [ Homo sapiens (human) ]

Gene ID: 155435, updated on 21-Mar-2023

Summary

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Official Symbol
RBM33provided by HGNC
Official Full Name
RNA binding motif protein 33provided by HGNC
Primary source
HGNC:HGNC:27223
See related
Ensembl:ENSG00000184863 AllianceGenome:HGNC:27223
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRR8
Summary
Enables RNA binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 11.9), skin (RPKM 7.9) and 25 other tissues See more
Orthologs
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Genomic context

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See RBM33 in Genome Data Viewer
Location:
7q36.3
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (155644661..155781480)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (156825729..156962514)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (155437355..155574174)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 10004 Neighboring gene RBM33 divergent transcript Neighboring gene VISTA enhancer hs1268 Neighboring gene Sharpr-MPRA regulatory region 9615 Neighboring gene Sharpr-MPRA regulatory region 3765 Neighboring gene sonic hedgehog signaling molecule Neighboring gene uncharacterized LOC124901788

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. DSSylation, a novel protein modification targets proteins induced by oxidative stress, and facilitates their degradation in cells. Zhang Y, et al. Protein Cell, 2014 Feb. PMID 24515614, Free PMC Article
  2. Endogenous purification reveals GREB1 as a key estrogen receptor regulatory factor. Mohammed H, et al. Cell Rep, 2013 Feb 21. PMID 23403292, Free PMC Article
  3. KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4. Kumar A, et al. Cell Rep, 2022 May 10. PMID 35545047, Free PMC Article
  4. HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137. Zhang F, et al. Elife, 2020 Jun 15. PMID 32538781, Free PMC Article
  5. A bead-based approach for large-scale identification of in vitro kinase substrates. Zhang M, et al. Proteomics, 2011 Dec. PMID 22113938

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC20460, DKFZp434D1319

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 

General protein information

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Preferred Names
RNA-binding protein 33
Names
hypothetical protein MGC20460
proline rich 8
proline-rich protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053043.3 → NP_444271.2  RNA-binding protein 33

    See identical proteins and their annotated locations for NP_444271.2

    Status: VALIDATED

    Source sequence(s)
    AC078834, AL137724, AL832196, BC011923, BP373239, CN402759, DA459140, DA504982, DA947894
    Consensus CDS
    CCDS5941.2
    UniProtKB/Swiss-Prot
    Q96EV2, Q9NSV0
    Related
    ENSP00000384160.3, ENST00000401878.8
    Conserved Domains (1) summary
    cd00590
    Location:1100 → 1165
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    155644661..155781480
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    156825729..156962514
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001008408.3: Suppressed sequence

    Description
    NM_001008408.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96EV2.3 GenPept UniProtKB/Swiss-Prot:Q96EV2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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