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Abcg8 ATP binding cassette subfamily G member 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 155192, updated on 8-Jan-2020

Summary

Official Symbol
Abcg8provided by RGD
Official Full Name
ATP binding cassette subfamily G member 8provided by RGD
Primary source
RGD:620300
See related
Ensembl:ENSRNOG00000005420
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
ATP-binding cassette (ABC) transporter that regulates sterol absorption and excretion; mutation causes sitosterolemia [RGD, Feb 2006]
Annotation information
Annotation category: suggests misassembly
Expression
Biased expression in Liver (RPKM 33.9), Kidney (RPKM 2.5) and 2 other tissues See more
Orthologs

Genomic context

See Abcg8 in Genome Data Viewer
Location:
6q12
Exon count:
14
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (7961413..7980708)
106 current Rn_Celera (GCF_000002265.2) 6 AC_000074.1 (9667270..9686500, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 6 NC_005105.3 (7897005..7916593)

Chromosome 6 - NC_005105.4Genomic Context describing neighboring genes Neighboring gene dynein cytoplasmic 2 light intermediate chain 1 Neighboring gene ATP binding cassette subfamily G member 5 Neighboring gene uncharacterized LOC102547702 Neighboring gene leucine-rich pentatricopeptide repeat containing Neighboring gene 60S ribosomal protein L26-like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to ATP binding ISO
Inferred from Sequence Orthology
more info
PubMed 
ATPase activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to ATPase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
ATPase activity, coupled to transmembrane movement of substances IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATPase activity, coupled to transmembrane movement of substances ISO
Inferred from Sequence Orthology
more info
PubMed 
ATPase activity, coupled to transmembrane movement of substances ISS
Inferred from Sequence or Structural Similarity
more info
 
intermembrane cholesterol transfer activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to intermembrane cholesterol transfer activity ISO
Inferred from Sequence Orthology
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
PubMed 
protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
cholesterol efflux IEA
Inferred from Electronic Annotation
more info
 
cholesterol efflux ISO
Inferred from Sequence Orthology
more info
PubMed 
cholesterol homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cholesterol homeostasis ISO
Inferred from Sequence Orthology
more info
PubMed 
excretion IEA
Inferred from Electronic Annotation
more info
 
excretion ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of intestinal cholesterol absorption IEA
Inferred from Electronic Annotation
more info
 
negative regulation of intestinal cholesterol absorption ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of intestinal phytosterol absorption IEA
Inferred from Electronic Annotation
more info
 
negative regulation of intestinal phytosterol absorption ISO
Inferred from Sequence Orthology
more info
PubMed 
phospholipid transport IEA
Inferred from Electronic Annotation
more info
 
phospholipid transport ISO
Inferred from Sequence Orthology
more info
PubMed 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to nutrient IEP
Inferred from Expression Pattern
more info
PubMed 
sterol homeostasis ISO
Inferred from Sequence Orthology
more info
PubMed 
sterol transport ISO
Inferred from Sequence Orthology
more info
PubMed 
sterol transport ISS
Inferred from Sequence or Structural Similarity
more info
 
transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
ATP-binding cassette (ABC) transporter complex ISO
Inferred from Sequence Orthology
more info
PubMed 
ATP-binding cassette (ABC) transporter complex ISS
Inferred from Sequence or Structural Similarity
more info
 
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor complex IEA
Inferred from Electronic Annotation
more info
 
receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
ATP-binding cassette sub-family G member 8
Names
ATP-binding cassette, sub-family G (WHITE), member 8
ATP-binding cassette, subfamily G (WHITE), member 8
sterolin 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130414.2NP_569098.2  ATP-binding cassette sub-family G member 8

    See identical proteins and their annotated locations for NP_569098.2

    Status: PROVISIONAL

    Source sequence(s)
    AF351785
    UniProtKB/Swiss-Prot
    P58428
    Related
    ENSRNOP00000007638.6, ENSRNOT00000007638.7
    Conserved Domains (3) summary
    cd03234
    Location:60295
    ABCG_White; White pigment protein homolog of ABCG transporter subfamily
    TIGR00955
    Location:88662
    3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
    pfam01061
    Location:401605
    ABC2_membrane; ABC-2 type transporter

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005105.4 Reference Rnor_6.0 Primary Assembly

    Range
    7961413..7980708
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008764453.2XP_008762675.1  ATP-binding cassette sub-family G member 8 isoform X1

    Conserved Domains (2) summary
    cd03234
    Location:1169
    ABCG_White; White pigment protein homolog of ABCG transporter subfamily
    pfam01061
    Location:275479
    ABC2_membrane; ABC-2 type transporter

Alternate Rn_Celera

Genomic

  1. AC_000074.1 Alternate Rn_Celera

    Range
    9667270..9686500 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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