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Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 [ Mus musculus (house mouse) ]

Gene ID: 15519, updated on 8-Jan-2023

Summary

Official Symbol
Hsp90aa1provided by MGI
Official Full Name
heat shock protein 90, alpha (cytosolic), class A member 1provided by MGI
Primary source
MGI:MGI:96250
See related
Ensembl:ENSMUSG00000021270 AllianceGenome:MGI:96250
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
hsp4; 86kDa; 89kDa; Hsp89; Hsp90; Hspca; Hsp86-1
Summary
Enables identical protein binding activity; nitric-oxide synthase regulator activity; and protein folding chaperone. Involved in several processes, including axonogenesis; positive regulation of nitrogen compound metabolic process; and positive regulation of protein kinase B signaling. Located in several cellular components, including growth cone; neuronal cell body; and ruffle membrane. Part of protein-containing complex. Is expressed in several structures, including 1st branchial arch; alimentary system; eye; genitourinary system; and nervous system. Orthologous to human HSP90AA1 (heat shock protein 90 alpha family class A member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 235.9), CNS E11.5 (RPKM 213.3) and 19 other tissues See more
Orthologs
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Genomic context

See Hsp90aa1 in Genome Data Viewer
Location:
12 F1; 12 60.75 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (110657470..110662829, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (110691036..110696395, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700001K19 gene Neighboring gene predicted gene, 53768 Neighboring gene WD repeat domain 20 Neighboring gene MOK protein kinase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transgenic (1) 
  • Gene trapped (2) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
 
enables CTP binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA polymerase binding ISO
Inferred from Sequence Orthology
more info
 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase binding ISO
Inferred from Sequence Orthology
more info
 
enables Rho GDP-dissociation inhibitor binding ISO
Inferred from Sequence Orthology
more info
 
enables TPR domain binding ISO
Inferred from Sequence Orthology
more info
 
enables UTP binding ISO
Inferred from Sequence Orthology
more info
 
enables dATP binding ISO
Inferred from Sequence Orthology
more info
 
enables disordered domain specific binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables disordered domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables nitric-oxide synthase regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables nitric-oxide synthase regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein folding chaperone IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
enables sulfonylurea receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables tau protein binding ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables unfolded protein binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in activation of innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in axon extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to heat IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to heat IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in central nervous system neuron axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chaperone-mediated protein complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron migration ISO
Inferred from Sequence Orthology
more info
 
involved_in nitric oxide biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of cell size ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytotoxic T cell differentiation TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of defense response to virus by host ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of nitric oxide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tau-protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of telomerase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein folding IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein insertion into mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in protein refolding TAS
Traceable Author Statement
more info
PubMed 
involved_in protein stabilization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in response to unfolded protein TAS
Traceable Author Statement
more info
PubMed 
involved_in telomerase holoenzyme complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in axonal growth cone IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
PubMed 
located_in dendritic growth cone IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 
is_active_in myelin sheath IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in myelin sheath ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of protein-containing complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
 
located_in sperm mitochondrial sheath ISO
Inferred from Sequence Orthology
more info
 
located_in sperm plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
heat shock protein HSP 90-alpha
Names
HSP 86
HSP86
TSTA
heat shock 86 kDa
heat shock protein 1, alpha
heat shock protein 90kDa alpha (cytosolic), class A member 1
heat shock protein, 1
heat shock protein, 86 kDa 1
heat shock protein, 89 kDa
tumor-specific transplantation 86 kDa antigen
NP_034610.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010480.5NP_034610.1  heat shock protein HSP 90-alpha

    See identical proteins and their annotated locations for NP_034610.1

    Status: PROVISIONAL

    Source sequence(s)
    AC152827, AL596265
    Consensus CDS
    CCDS26172.1
    UniProtKB/Swiss-Prot
    P07901
    UniProtKB/TrEMBL
    Q80Y52
    Related
    ENSMUSP00000091921.5, ENSMUST00000094361.11
    Conserved Domains (3) summary
    smart00387
    Location:40191
    HATPase_c; Histidine kinase-like ATPases
    PTZ00272
    Location:18733
    PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional
    pfam00183
    Location:196723
    HSP90; Hsp90 protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    110657470..110662829 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)