Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hsp90aa1provided by MGI
Official Full Name: heat shock protein 90, alpha (cytosolic), class A member 1provided by MGI
Primary source: MGI:MGI:96250
See related: Ensembl:ENSMUSG00000021270 AllianceGenome:MGI:96250
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: hsp4; 86kDa; 89kDa; Hsp89; Hsp90; Hspca; Hsp86-1
Summary: Enables identical protein binding activity; nitric-oxide synthase regulator activity; and protein folding chaperone. Involved in several processes, including axonogenesis; positive regulation of nitrogen compound metabolic process; and positive regulation of protein kinase B signaling. Located in several cellular components, including growth cone; neuronal cell body; and ruffle membrane. Part of protein-containing complex. Is expressed in several structures, including 1st branchial arch; alimentary system; eye; genitourinary system; and nervous system. Orthologous to human HSP90AA1 (heat shock protein 90 alpha family class A member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in placenta adult (RPKM 235.9), CNS E11.5 (RPKM 213.3) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 F1; 12 60.75 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2023_04	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (110657470..110662829, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (110691036..110696395, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

USP14 governs CYP2E1 to promote nonalcoholic fatty liver disease through deubiquitination and stabilization of HSP90AA1.
Title: USP14 governs CYP2E1 to promote nonalcoholic fatty liver disease through deubiquitination and stabilization of HSP90AA1.
HSP90alpha is needed for the survival of rod photoreceptors and regulates the expression of rod PDE6 subunits.
Title: HSP90α is needed for the survival of rod photoreceptors and regulates the expression of rod PDE6 subunits.
Inhibition of HSP90 and Activation of HSF1 Diminish Macrophage NLRP3 Inflammasome Activity in Alcohol-Associated Liver Injury.
Title: Inhibition of HSP90 and Activation of HSF1 Diminish Macrophage NLRP3 Inflammasome Activity in Alcohol-Associated Liver Injury.
Low-Dose Hsp90 Inhibitor Selectively Radiosensitizes HNSCC and Pancreatic Xenografts.
Title: Low-Dose Hsp90 Inhibitor Selectively Radiosensitizes HNSCC and Pancreatic Xenografts.
Participation of Hsp70 and Hsp90alpha Heat Shock Proteins in Stress Response in the Course of Type 1 Diabetes Mellitus.
Title: Participation of Hsp70 and Hsp90α Heat Shock Proteins in Stress Response in the Course of Type 1 Diabetes Mellitus.
Mutant p53 Drives Cancer Metastasis via RCP-Mediated Hsp90alpha Secretion.
Title: Mutant p53 Drives Cancer Metastasis via RCP-Mediated Hsp90α Secretion.
Hsp90 inhibition aggravates adriamycin-induced podocyte injury through intrinsic apoptosis pathway.
Title: Hsp90 inhibition aggravates adriamycin-induced podocyte injury through intrinsic apoptosis pathway.
Involvement of Hsp90 and cyclophilins in intoxication by AIP56, a metalloprotease toxin from Photobacterium damselae subsp. piscicida.
Title: Involvement of Hsp90 and cyclophilins in intoxication by AIP56, a metalloprotease toxin from Photobacterium damselae subsp. piscicida.
ZMYND10 is a novel co-chaperone that confers specificity for the FKBP8-HSP90 chaperone complex towards axonemal dynein clients required for cilia motility.
Title: ZMYND10 functions in a chaperone relay during axonemal dynein assembly.
Study found that the chaperone-defective Hsp90alpha-Delta mutant mice showed similar wound closure rate as the wild-type Hsp90alpha mice and provides direct support for non-chaperone, extracellular Hsp90alpha as a potential driver for normal wound closure.
Title: Extracellular and Non-Chaperone Function of Heat Shock Protein-90α Is Required for Skin Wound Healing.

Submit: New GeneRIF Correction See all GeneRIFs (49)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Transgenic (1)
Gene trapped (2)
Targeted (3) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125493 (e-PCR)
- UniSTS:162311

Hspca (e-PCR), detects polymorphism
- UniSTS:461999

RH125470 (e-PCR)
- UniSTS:162289

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables CTP binding	ISO Inferred from Sequence Orthology more info
enables DNA polymerase binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTPase binding	ISO Inferred from Sequence Orthology more info
enables Rho GDP-dissociation inhibitor binding	ISO Inferred from Sequence Orthology more info
enables TPR domain binding	ISO Inferred from Sequence Orthology more info
enables UTP binding	ISO Inferred from Sequence Orthology more info
enables dATP binding	ISO Inferred from Sequence Orthology more info
enables disordered domain specific binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables disordered domain specific binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables nitric-oxide synthase regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables nitric-oxide synthase regulator activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein folding chaperone	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables sulfonylurea receptor binding	ISO Inferred from Sequence Orthology more info
enables tau protein binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables unfolded protein binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in activation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to heat	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in cellular response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to virus	ISO Inferred from Sequence Orthology more info
involved_in central nervous system neuron axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaperone-mediated protein complex assembly	ISO Inferred from Sequence Orthology more info
involved_in establishment of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron migration	ISO Inferred from Sequence Orthology more info
involved_in nitric oxide biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of cell size	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytotoxic T cell differentiation	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of defense response to virus by host	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interferon-beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric oxide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein polymerization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tau-protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of telomerase activity	ISO Inferred from Sequence Orthology more info
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in protein folding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein insertion into mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
involved_in protein refolding	TAS Traceable Author Statement more info	PubMed
involved_in protein stabilization	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in response to unfolded protein	TAS Traceable Author Statement more info	PubMed
involved_in telomerase holoenzyme complex assembly	ISO Inferred from Sequence Orthology more info
involved_in telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in axonal growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info	PubMed
located_in dendritic growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular anatomical structure	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in myelin sheath	HDA more info	PubMed
is_active_in myelin sheath	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in myelin sheath	ISO Inferred from Sequence Orthology more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of protein-containing complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in sperm flagellum	ISO Inferred from Sequence Orthology more info
located_in sperm mitochondrial sheath	ISO Inferred from Sequence Orthology more info
located_in sperm plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: heat shock protein HSP 90-alpha

Names: HSP 86; HSP86; TSTA; heat shock 86 kDa; heat shock protein 1, alpha; heat shock protein 90kDa alpha (cytosolic), class A member 1; heat shock protein, 1; heat shock protein, 86 kDa 1; heat shock protein, 89 kDa; tumor-specific transplantation 86 kDa antigen

NP_034610.1

EC 3.6.4.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010480.5 → NP_034610.1 heat shock protein HSP 90-alpha

See identical proteins and their annotated locations for NP_034610.1

Status: PROVISIONAL

Source sequence(s)

AC152827, AL596265

Consensus CDS

CCDS26172.1

UniProtKB/Swiss-Prot

P07901

UniProtKB/TrEMBL

Q3TKA2, Q80Y52

Related

ENSMUSP00000091921.5, ENSMUST00000094361.11

Conserved Domains (3) summary

smart00387
Location:40 → 191

HATPase_c; Histidine kinase-like ATPases

PTZ00272
Location:18 → 733

PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional

pfam00183
Location:196 → 723

HSP90; Hsp90 protein