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AMZ1 archaelysin family metallopeptidase 1 [ Homo sapiens (human) ]

Gene ID: 155185, updated on 11-Jun-2021

Summary

Official Symbol
AMZ1provided by HGNC
Official Full Name
archaelysin family metallopeptidase 1provided by HGNC
Primary source
HGNC:HGNC:22231
See related
Ensembl:ENSG00000174945 MIM:615168
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in brain (RPKM 1.1), endometrium (RPKM 0.6) and 7 other tissues See more
Orthologs
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Genomic context

See AMZ1 in Genome Data Viewer
Location:
7p22.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (2679522..2765187)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (2719156..2804772)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene tweety family member 3 Neighboring gene Sharpr-MPRA regulatory region 3776 Neighboring gene G protein subunit alpha 12 Neighboring gene prefoldin subunit 4 pseudogene Neighboring gene Sharpr-MPRA regulatory region 5898

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1950

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
archaemetzincin-1
Names
archeobacterial metalloproteinase-like protein 1
metalloproteinase-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284355.4NP_001271284.1  archaemetzincin-1 isoform 2

    See identical proteins and their annotated locations for NP_001271284.1

    Status: VALIDATED

    Source sequence(s)
    AC006028
    Consensus CDS
    CCDS64582.1
    UniProtKB/Swiss-Prot
    Q400G9
    UniProtKB/TrEMBL
    A4D202
    Related
    ENSP00000386020.1, ENST00000407112.1
    Conserved Domains (1) summary
    cl00064
    Location:95201
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
  2. NM_001321766.2NP_001308695.1  archaemetzincin-1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC006028
    UniProtKB/Swiss-Prot
    Q400G9
    UniProtKB/TrEMBL
    A4D202
    Conserved Domains (1) summary
    cd11375
    Location:95305
    Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
  3. NM_001384739.1NP_001371668.1  archaemetzincin-1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC006028
    Conserved Domains (1) summary
    cd11375
    Location:95282
    Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
  4. NM_001384740.1NP_001371669.1  archaemetzincin-1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC006028
    Conserved Domains (1) summary
    cd11375
    Location:95305
    Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
  5. NM_001384741.1NP_001371670.1  archaemetzincin-1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC006028
  6. NM_001384742.1NP_001371671.1  archaemetzincin-1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC006028
    Conserved Domains (1) summary
    PHA03247
    Location:197286
    PHA03247; large tegument protein UL36; Provisional
  7. NM_001384743.1NP_001371672.1  archaemetzincin-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC006028
    Related
    ENSP00000506962.1, ENST00000683327.1
    Conserved Domains (1) summary
    cd11375
    Location:95305
    Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
  8. NM_133463.4NP_597720.1  archaemetzincin-1 isoform 1

    See identical proteins and their annotated locations for NP_597720.1

    Status: VALIDATED

    Source sequence(s)
    AC006028
    Consensus CDS
    CCDS34589.1
    UniProtKB/Swiss-Prot
    Q400G9
    UniProtKB/TrEMBL
    A4D202
    Related
    ENSP00000308149.4, ENST00000312371.8
    Conserved Domains (1) summary
    cd11375
    Location:95305
    Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    2679522..2765187
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515151.3XP_011513453.1  archaemetzincin-1 isoform X2

    Conserved Domains (1) summary
    cl00064
    Location:95201
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
  2. XM_017011776.1XP_016867265.1  archaemetzincin-1 isoform X4

  3. XM_017011775.2XP_016867264.1  archaemetzincin-1 isoform X3

  4. XM_017011774.2XP_016867263.1  archaemetzincin-1 isoform X2

    Conserved Domains (1) summary
    cl00064
    Location:95201
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
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