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Hspa2 heat shock protein 2 [ Mus musculus (house mouse) ]

Gene ID: 15512, updated on 9-Mar-2023

Summary

Official Symbol
Hspa2provided by MGI
Official Full Name
heat shock protein 2provided by MGI
Primary source
MGI:MGI:96243
See related
Ensembl:ENSMUSG00000059970 AllianceGenome:MGI:96243
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
70kDa; HSP70.2; HSP70A2; Hsp70-2
Summary
Enables glycolipid binding activity. Involved in positive regulation of ATPase activity; positive regulation of ATPase-coupled calcium transmembrane transporter activity; and spermatogenesis. Acts upstream of or within several processes, including male gamete generation; positive regulation of G2/M transition of mitotic cell cycle; and synaptonemal complex disassembly. Located in cell surface; meiotic spindle; and nucleus. Part of CatSper complex. Is expressed in alimentary system; ganglia; medulla oblongata basal plate; testis; and vibrissa. Orthologous to human HSPA2 (heat shock protein family A (Hsp70) member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 333.5), bladder adult (RPKM 20.6) and 1 other tissue See more
Orthologs
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Genomic context

See Hspa2 in Genome Data Viewer
Location:
12 C3; 12 33.73 cM
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (76450559..76453712)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (76403812..76406938)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene A kinase (PRKA) anchor protein 5 Neighboring gene zinc finger and BTB domain containing 25 Neighboring gene zinc finger and BTB domain containing 1 Neighboring gene RIKEN cDNA 4930426I24 gene Neighboring gene protein phosphatase 1, regulatory subunit 36 Neighboring gene predicted gene, 25563 Neighboring gene Ppp1r36 downstream neighbor

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC7795, MGC58299

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
 
enables disordered domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables glycolipid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables heat shock protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein folding chaperone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
 
enables tau protein binding ISO
Inferred from Sequence Orthology
more info
 
enables unfolded protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within male meiosis I IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within male meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of inclusion body assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ATP-dependent activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ATPase-coupled calcium transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein refolding ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spermatid development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within synaptonemal complex disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of CatSper complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in meiotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion HDA PubMed 
located_in myelin sheath HDA PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in synaptonemal complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
heat shock-related 70 kDa protein 2
Names
heat shock 70kDa protein 2
heat shock protein 70.2
heat shock protein, 70 kDa 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002012.2NP_001002012.1  heat shock-related 70 kDa protein 2

    See identical proteins and their annotated locations for NP_001002012.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' sequence and encodes the same protein, as compared to variant 1.
    Source sequence(s)
    BC052350
    Consensus CDS
    CCDS25993.1
    UniProtKB/Swiss-Prot
    P17156, Q99KD7
    UniProtKB/TrEMBL
    A0A6P5R067
    Related
    ENSMUSP00000079306.6, ENSMUST00000080449.7
    Conserved Domains (1) summary
    PTZ00009
    Location:2615
    PTZ00009; heat shock 70 kDa protein; Provisional
  2. NM_001409571.1NP_001396500.1  heat shock-related 70 kDa protein 2

    Status: VALIDATED

    Source sequence(s)
    AC124453
    UniProtKB/Swiss-Prot
    Q99KD7
    UniProtKB/TrEMBL
    A0A6P5R067
  3. NM_001409572.1NP_001396501.1  heat shock-related 70 kDa protein 2

    Status: VALIDATED

    Source sequence(s)
    AC124453
    UniProtKB/Swiss-Prot
    Q99KD7
    UniProtKB/TrEMBL
    A0A6P5R067
  4. NM_008301.5NP_032327.2  heat shock-related 70 kDa protein 2

    See identical proteins and their annotated locations for NP_032327.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longest transcript. All variants encode the same protein.
    Source sequence(s)
    AK132261, BC052350
    Consensus CDS
    CCDS25993.1
    UniProtKB/Swiss-Prot
    P17156, Q99KD7
    UniProtKB/TrEMBL
    A0A6P5R067
    Related
    ENSMUSP00000151408.2, ENSMUST00000219555.2
    Conserved Domains (1) summary
    PTZ00009
    Location:2615
    PTZ00009; heat shock 70 kDa protein; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    76450559..76453712
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515484.5XP_006515547.1  heat shock-related 70 kDa protein 2 isoform X1

    UniProtKB/Swiss-Prot
    P17156
    Conserved Domains (1) summary
    PTZ00009
    Location:2615
    PTZ00009; heat shock 70 kDa protein; Provisional