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Hsf2 heat shock factor 2 [ Mus musculus (house mouse) ]

Gene ID: 15500, updated on 13-Dec-2022

Summary

Official Symbol
Hsf2provided by MGI
Official Full Name
heat shock factor 2provided by MGI
Primary source
MGI:MGI:96239
See related
Ensembl:ENSMUSG00000019878 AllianceGenome:MGI:96239
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and identical protein binding activity. Acts upstream of or within spermatogenesis. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; future midbrain; genitourinary system; heart; and limb bud. Orthologous to human HSF2 (heat shock transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 5.1), CNS E14 (RPKM 4.1) and 22 other tissues See more
Orthologs
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Genomic context

See Hsf2 in Genome Data Viewer
Location:
10; 10 B4
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (57359862..57389239)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (57483766..57513143)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene phosphoglucomutase 2 pseudogene Neighboring gene interleukin 25 pseudogene Neighboring gene RIKEN cDNA 4930467K11 gene Neighboring gene serine incorporator 1 Neighboring gene ribosomal protein L48, pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
heat shock factor protein 2
Names
HSF 2
HSTF 2
heat shock transcription factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008297.3NP_032323.3  heat shock factor protein 2

    See identical proteins and their annotated locations for NP_032323.3

    Status: VALIDATED

    Source sequence(s)
    AK052270, AK053976, BB823041
    Consensus CDS
    CCDS23852.1
    UniProtKB/Swiss-Prot
    P38533
    UniProtKB/TrEMBL
    Q8BWK6
    Related
    ENSMUSP00000078761.5, ENSMUST00000079833.6
    Conserved Domains (2) summary
    smart00415
    Location:6110
    HSF; heat shock factor
    pfam06546
    Location:230493
    Vert_HS_TF; Vertebrate heat shock transcription factor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    57359862..57389239
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512564.4XP_006512627.1  heat shock factor protein 2 isoform X1

    Conserved Domains (2) summary
    smart00415
    Location:6110
    HSF; heat shock factor
    pfam06546
    Location:230511
    Vert_HS_TF; Vertebrate heat shock transcription factor
  2. XM_006512565.5XP_006512628.1  heat shock factor protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A1W2P8F8
    Related
    ENSMUSP00000152013.2, ENSMUST00000220042.2
    Conserved Domains (2) summary
    smart00415
    Location:153
    HSF; heat shock factor
    pfam06546
    Location:173454
    Vert_HS_TF; Vertebrate heat shock transcription factor
  3. XM_036155647.1XP_036011540.1  heat shock factor protein 2 isoform X3

    Conserved Domains (2) summary
    smart00415
    Location:153
    HSF; heat shock factor
    pfam06546
    Location:173436
    Vert_HS_TF; Vertebrate heat shock transcription factor