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ADRB3 adrenoceptor beta 3 [ Homo sapiens (human) ]

Gene ID: 155, updated on 4-Jun-2020

Summary

Official Symbol
ADRB3provided by HGNC
Official Full Name
adrenoceptor beta 3provided by HGNC
Primary source
HGNC:HGNC:288
See related
Ensembl:ENSG00000188778 MIM:109691
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BETA3AR
Summary
The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. Obesity and bodyweight-related disorders are correlated with certain polymorphisms in three subtypes of beta-adrenoceptor, among them, the ADRB3 gene.[provided by RefSeq, Oct 2019]
Expression
Biased expression in ovary (RPKM 4.0), placenta (RPKM 1.7) and 3 other tissues See more
Orthologs

Genomic context

See ADRB3 in Genome Data Viewer
Location:
8p11.23
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (37962990..37966599, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (37820513..37824184, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 709, pseudogene Neighboring gene glutamic-oxaloacetic transaminase 1 like 1 Neighboring gene Sharpr-MPRA regulatory region 54 Neighboring gene eukaryotic translation initiation factor 4E binding protein 1 Neighboring gene CRISPRi-validated cis-regulatory element chr8.1253

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ99960

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
beta-adrenergic receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
beta3-adrenergic receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
beta3-adrenergic receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
epinephrine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to norepinephrine binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
beta-3 adrenergic receptor
Names
adrenergic, beta-3-, receptor
beta-3 adrenoceptor
beta-3 adrenoreceptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011936.1 RefSeqGene

    Range
    5068..8677
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000025.3NP_000016.1  beta-3 adrenergic receptor

    See identical proteins and their annotated locations for NP_000016.1

    Status: REVIEWED

    Source sequence(s)
    AC144573, BQ024407, DA904248, X70811
    Consensus CDS
    CCDS6099.1
    UniProtKB/Swiss-Prot
    P13945
    UniProtKB/TrEMBL
    A8KAG8
    Related
    ENSP00000343782.3, ENST00000345060.5
    Conserved Domains (2) summary
    cd14964
    Location:7395
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:51356
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    37962990..37966599 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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