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CYP2A7 cytochrome P450 family 2 subfamily A member 7 [ Homo sapiens (human) ]

Gene ID: 1549, updated on 23-Nov-2021

Summary

Official Symbol
CYP2A7provided by HGNC
Official Full Name
cytochrome P450 family 2 subfamily A member 7provided by HGNC
Primary source
HGNC:HGNC:2611
See related
Ensembl:ENSG00000198077 MIM:608054
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPA7; CPAD; CYP2A; CYPIIA7; P450-IIA4
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum; its substrate has not yet been determined. This gene, which produces two transcript variants, is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward liver (RPKM 27.5) See more
Orthologs
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Genomic context

See CYP2A7 in Genome Data Viewer
Location:
19q13.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (40875439..40885951, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (41381344..41388136, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 4763 Neighboring gene CYP2A6 5' regulatory region Neighboring gene cytochrome P450 family 2 subfamily A member 6 Neighboring gene uncharacterized LOC107985299 Neighboring gene Sharpr-MPRA regulatory region 12493 Neighboring gene cytochrome P450 family 2 subfamily G member 1, pseudogene Neighboring gene cytochrome P450 family 2 subfamily B member 7, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables arachidonic acid epoxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables aromatase activity IEA
Inferred from Electronic Annotation
more info
 
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables oxygen binding TAS
Traceable Author Statement
more info
PubMed 
enables steroid hydroxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in coumarin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in epoxygenase P450 pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in organic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cytochrome P450 2A7
Names
cytochrome P450 IIA4
cytochrome P450, family 2, subfamily A, polypeptide 7
cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 7
cytochrome P450IIA4
NP_000755.2
NP_085079.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007960.1 RefSeqGene

    Range
    5001..12314
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000764.3NP_000755.2  cytochrome P450 2A7 isoform 1 precursor

    See identical proteins and their annotated locations for NP_000755.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC008537
    Consensus CDS
    CCDS12569.1
    UniProtKB/Swiss-Prot
    P20853
    Related
    ENSP00000301146.4, ENST00000301146.9
    Conserved Domains (1) summary
    pfam00067
    Location:34491
    p450; Cytochrome P450
  2. NM_030589.3NP_085079.2  cytochrome P450 2A7 isoform 2 precursor

    See identical proteins and their annotated locations for NP_085079.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as CYP2A7AS) lacks exon 2 within the coding region and includes 10 nt from intron 1, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. This variant lacks publicly available transcript support but it is supported by data in PubMedID:7864805.
    Source sequence(s)
    AC008537
    UniProtKB/Swiss-Prot
    P20853
    UniProtKB/TrEMBL
    F8W816
    Related
    ENSP00000291764.3, ENST00000291764.3
    Conserved Domains (1) summary
    pfam00067
    Location:34440
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    40875439..40885951 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_935754.3 RNA Sequence

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