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Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 [ Mus musculus (house mouse) ]

Gene ID: 15484, updated on 5-Aug-2018

Summary

Official Symbol
Hsd11b2provided by MGI
Official Full Name
hydroxysteroid 11-beta dehydrogenase 2provided by MGI
Primary source
MGI:MGI:104720
See related
Ensembl:ENSMUSG00000031891 Vega:OTTMUSG00000062049
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
11HSD2
Expression
Biased expression in colon adult (RPKM 298.3), kidney adult (RPKM 127.6) and 4 other tissues See more
Orthologs

Genomic context

See Hsd11b2 in Genome Data Viewer
Location:
8 D3; 8 53.04 cM
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (105518746..105523988)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (108042646..108047888)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene zinc finger, DHHC domain containing 1 Neighboring gene ferritin light chain 1 pseudogene Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit D1 Neighboring gene predicted gene, 38250 Neighboring gene agouti related neuropeptide

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity ISO
Inferred from Sequence Orthology
more info
 
NAD binding ISO
Inferred from Sequence Orthology
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
steroid binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
female pregnancy IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucocorticoid metabolic process ISO
Inferred from Sequence Orthology
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
regulation of blood volume by renal aldosterone ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
corticosteroid 11-beta-dehydrogenase isozyme 2
Names
11-DH2
11-beta-HSD2
11-beta-hydroxysteroid dehydrogenase type 2
NAD-dependent 11-beta-hydroxysteroid dehydrogenase
NP_032315.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008289.2NP_032315.2  corticosteroid 11-beta-dehydrogenase isozyme 2

    See identical proteins and their annotated locations for NP_032315.2

    Status: VALIDATED

    Source sequence(s)
    AC151573, BB618868, BC066209
    Consensus CDS
    CCDS40460.1
    UniProtKB/Swiss-Prot
    P51661
    UniProtKB/TrEMBL
    Q6NZB9
    Related
    ENSMUSP00000034363.5, OTTMUSP00000078556, ENSMUST00000034363.6, OTTMUST00000151485
    Conserved Domains (2) summary
    cd09805
    Location:83363
    type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs
    pfam00106
    Location:83278
    adh_short; short chain dehydrogenase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

    Range
    105518746..105523988
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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