Hs3st1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hs3st1provided by MGI
Official Full Name: heparan sulfate (glucosamine) 3-O-sulfotransferase 1provided by MGI
Primary source: MGI:MGI:1201606
See related: Ensembl:ENSMUSG00000051022 AllianceGenome:MGI:1201606
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 3-Ost; Hsg3ost; D5Wsu110e
Summary: Predicted to enable [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. Predicted to be located in Golgi apparatus. Is expressed in several structures, including alimentary system; appendicular skeleton; ear; hindlimb; and nervous system. Orthologous to human HS3ST1 (heparan sulfate-glucosamine 3-sulfotransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in ovary adult (RPKM 31.6), lung adult (RPKM 23.9) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 B3; 5 21.14 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (39771278..39802935, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (39613935..39645592, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The expression of heparan sulfate sulfotransferases was examined by in situ hybridization.
Title: Histochemical analysis of heparan sulfate 3-O-sulfotransferase expression in mouse brain.
Crystal structure of the binary complex of 3-OST-1 and PAP provide information essential for understanding the biosynthesis of anticoagulant heparan sulfate and the general mechanism of action of heparan sulfate sulfotransferases.
Title: Crystal structure and mutational analysis of heparan sulfate 3-O-sulfotransferase isoform 1.
the 3-OST-1 enzyme produces the majority of tissue anticoagulant heparan sulfate
Title: Normal levels of anticoagulant heparan sulfate are not essential for normal hemostasis.
Hs3st1(-/-) mice do not show an obvious procoagulant phenotype.
Title: Mice deficient in heparan sulfate 3-O-sulfotransferase-1: normal hemostasis with unexpected perinatal phenotypes.
In this paper a conformational change is described that occurs in heparan sulfate 3-O-sulfotransferase-1 upon binding to heparan sulfate.
Title: A conformational change in heparan sulfate 3-O-sulfotransferase-1 is induced by binding to heparan sulfate.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

General gene information

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Markers

D5Dmo6 (e-PCR), detects polymorphism
- UniSTS:233994

Hs3st1 (e-PCR), detects polymorphism
- UniSTS:532545

Hs3st1 (e-PCR), detects polymorphism
- UniSTS:532606

AA963021 (e-PCR)
- UniSTS:247992

D5Wsu110e (e-PCR), detects polymorphism
- UniSTS:142564

Homology

Homologs of the Hs3st1 gene: The Hs3st1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 489 organisms have orthologs with human gene Hs3st1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity	IDA Inferred from Direct Assay more info	PubMed
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity	ISO Inferred from Sequence Orthology more info
enables sulfotransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glycosaminoglycan biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glycosaminoglycan biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in heparan sulfate proteoglycan biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in heparan sulfate proteoglycan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: heparan sulfate glucosamine 3-O-sulfotransferase 1

Names: heparan sulfate 3-O-sulfotransferase 1; heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1

NP_034604.1

EC 2.8.2.23

XP_017176175.1

EC 2.8.2.23

XP_030110027.1

EC 2.8.2.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010474.2 → NP_034604.1 heparan sulfate glucosamine 3-O-sulfotransferase 1 precursor

See identical proteins and their annotated locations for NP_034604.1

Status: VALIDATED

Source sequence(s)

AK087753, BY585739, CJ144446

Consensus CDS

CCDS19257.1

UniProtKB/Swiss-Prot

O35310

UniProtKB/TrEMBL

A0A6P5PVD4, A0A8C6IHM7

Related

ENSMUSP00000051055.7, ENSMUST00000053116.7

Conserved Domains (1) summary

pfam00685
Location:58 → 295

Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

39771278..39802935 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017320686.2 → XP_017176175.1 heparan sulfate glucosamine 3-O-sulfotransferase 1 isoform X1

UniProtKB/Swiss-Prot

O35310

UniProtKB/TrEMBL

A0A6P5PVD4, A0A8C6IHM7

Conserved Domains (1) summary

pfam00685
Location:58 → 295

Sulfotransfer_1; Sulfotransferase domain
XM_030254167.1 → XP_030110027.1 heparan sulfate glucosamine 3-O-sulfotransferase 1 isoform X1

UniProtKB/Swiss-Prot

O35310

UniProtKB/TrEMBL

A0A6P5PVD4, A0A8C6IHM7

Conserved Domains (1) summary

pfam00685
Location:58 → 295

Sulfotransfer_1; Sulfotransferase domain