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PRSS3P2 PRSS3 pseudogene 2 [ Homo sapiens (human) ]

Gene ID: 154754, updated on 13-May-2022

Summary

Official Symbol
PRSS3P2provided by HGNC
Official Full Name
PRSS3 pseudogene 2provided by HGNC
Primary source
HGNC:HGNC:43788
Gene type
pseudo
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
T6; TRY6
Summary
Although this locus appears to encode a protein similar to trypsinogen, the locus is thought to be a transcribed pseudogene. ESTs support its transcription, but expression of its predicted protein has not been observed. Its predicted protein sequence differs significantly from the known functional trypsinogens, including a different amino acid at the conserved residue 122 which is important for autolysis. This pseudogene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008]
Annotation information
Annotation category: only annotated on alternate loci in reference assembly
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Genomic context

See PRSS3P2 in Genome Data Viewer
Location:
7q34
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 (ALT_REF_LOCI_1) NT_187562.1 (773503..777146)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 (PATCHES) NW_003571040.1 (953574..957217)

NT_187562.1Genomic Context describing neighboring genes Neighboring gene T cell receptor beta locus Neighboring gene PRSS3 pseudogene 1 Neighboring gene serine protease 1 Neighboring gene trypsinogen D Neighboring gene serine protease 2

Genomic regions, transcripts, and products

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Other Names

  • Putative trypsin-6
  • Serine protease 3 pseudogene 2
  • protease, serine 3 pseudogene 2
  • protease, serine, 1 (trypsin 1)
  • trypsinogen C

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_001333.2 

    Range
    604575..608219
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. NR_001296.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC231380

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187562.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    773503..777146
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_139000.2: Suppressed sequence

    Description
    NM_139000.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.