U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hras Harvey rat sarcoma virus oncogene [ Mus musculus (house mouse) ]

Gene ID: 15461, updated on 8-Jul-2024

Summary

Official Symbol
Hrasprovided by MGI
Official Full Name
Harvey rat sarcoma virus oncogeneprovided by MGI
Primary source
MGI:MGI:96224
See related
Ensembl:ENSMUSG00000025499 AllianceGenome:MGI:96224
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ras; H-ras; Hras1; Kras2; Ha-ras; Hras-1; c-H-ras; c-rasHa; c-Ha-ras; Harvey-ras
Summary
Enables GTP binding activity. Involved in Ras protein signal transduction. Acts upstream of or within several processes, including defense response to protozoan; intracellular signal transduction; and positive regulation of interferon-gamma production. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be active in glutamatergic synapse and plasma membrane. Is expressed in several structures, including central nervous system; early embryo; metanephros; sensory organ; and tooth. Used to study Costello syndrome; high grade glioma; and malignant astrocytoma. Human ortholog(s) of this gene implicated in several diseases, including Costello syndrome; autistic disorder; carcinoma (multiple); epidermal nevus; and large congenital melanocytic nevus. Orthologous to human HRAS (HRas proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 31.5), cortex adult (RPKM 31.3) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Hras in Genome Data Viewer
Location:
7 F5; 7 86.48 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (140770839..140773938, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141189934..141194019, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S9 pseudogene Neighboring gene predicted gene, 51459 Neighboring gene predicted gene, 22019 Neighboring gene STARR-positive B cell enhancer ABC_E9115 Neighboring gene STARR-positive B cell enhancer ABC_E11375 Neighboring gene leucine rich repeat containing 56 Neighboring gene lamin tail domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E1749 Neighboring gene Ras association (RalGDS/AF-6) domain family (N-terminal) member 7

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (11)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
 
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GDP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-membrane adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-membrane adaptor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
involved_in ERBB2-ERBB3 signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in Ras protein signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within Ras protein signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in Schwann cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within T-helper 1 type immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adipose tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to gamma radiation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular senescence IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cellular senescence IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular senescence ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within defense response to protozoan IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of fibroblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in insulin-like growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within oncogene-induced cell senescence IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell population proliferation IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of fibroblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of miRNA metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein targeting to membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ruffle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of type II interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of wound healing ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within small GTPase-mediated signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of GTPase complex ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
GTPase HRas
Names
H-Ras-1
H-ras 1 protein
Harvey rat sarcoma virus oncogene 1
c-Ha-ras p21 protein
c-Ha-ras transgene
p21ras
transforming protein P21
NP_001123915.1
NP_001123916.1
NP_001399407.1
NP_001399408.1
NP_001399409.1
NP_001399410.1
NP_032310.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130443.2NP_001123915.1  GTPase HRas isoform 1

    See identical proteins and their annotated locations for NP_001123915.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR, compared to variant 1, and encodes isoform 1. Variants 1 and 3-7 all encode the same isoform (1).
    Source sequence(s)
    AC108908
    Consensus CDS
    CCDS22003.1
    UniProtKB/Swiss-Prot
    F7BIB2, Q61411, Q6P716, Q80WD2, Q811B9
    UniProtKB/TrEMBL
    Q9R0B8
    Related
    ENSMUSP00000095570.5, ENSMUST00000097957.11
    Conserved Domains (1) summary
    cd04138
    Location:3164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
  2. NM_001130444.2NP_001123916.1  GTPase HRas isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and includes an alternate exon in its 3' coding region, compared to variant 1. The resulting isoform (2) contains a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC108908
    Consensus CDS
    CCDS52439.1
    UniProtKB/TrEMBL
    A0A0G2JGP4
    Related
    ENSMUSP00000132110.2, ENSMUST00000168550.8
    Conserved Domains (2) summary
    cd04138
    Location:3150
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
    smart00010
    Location:16150
    small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
  3. NM_001412478.1NP_001399407.1  GTPase HRas isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC108908
    UniProtKB/Swiss-Prot
    F7BIB2, Q61411, Q6P716, Q80WD2, Q811B9
    UniProtKB/TrEMBL
    Q9R0B8
  4. NM_001412479.1NP_001399408.1  GTPase HRas isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC108908
    UniProtKB/Swiss-Prot
    F7BIB2, Q61411, Q6P716, Q80WD2, Q811B9
    UniProtKB/TrEMBL
    Q9R0B8
  5. NM_001412480.1NP_001399409.1  GTPase HRas isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC108908
    UniProtKB/Swiss-Prot
    F7BIB2, Q61411, Q6P716, Q80WD2, Q811B9
    UniProtKB/TrEMBL
    Q9R0B8
  6. NM_001412481.1NP_001399410.1  GTPase HRas isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC108908
    UniProtKB/Swiss-Prot
    F7BIB2, Q61411, Q6P716, Q80WD2, Q811B9
    UniProtKB/TrEMBL
    Q9R0B8
  7. NM_008284.3NP_032310.2  GTPase HRas isoform 1

    See identical proteins and their annotated locations for NP_032310.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Isoform 1 is also known as p21. Variants 1 and 3-7 all encode the same isoform (1).
    Source sequence(s)
    AC108908
    Consensus CDS
    CCDS22003.1
    UniProtKB/Swiss-Prot
    F7BIB2, Q61411, Q6P716, Q80WD2, Q811B9
    UniProtKB/TrEMBL
    Q9R0B8
    Related
    ENSMUSP00000026572.5, ENSMUST00000026572.11
    Conserved Domains (1) summary
    cd04138
    Location:3164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

RNA

  1. NR_178203.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC108908
  2. NR_178204.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC108908
  3. NR_178205.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC108908
  4. NR_178206.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC108908

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    140770839..140773938 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003946393.2 RNA Sequence

  2. XR_389952.4 RNA Sequence

    Related
    ENSMUST00000124971.2
  3. XR_004934018.1 RNA Sequence