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Hprt hypoxanthine guanine phosphoribosyl transferase [ Mus musculus (house mouse) ]

Gene ID: 15452, updated on 7-Feb-2023

Summary

Official Symbol
Hprtprovided by MGI
Official Full Name
hypoxanthine guanine phosphoribosyl transferaseprovided by MGI
Primary source
MGI:MGI:96217
See related
Ensembl:ENSMUSG00000025630 AllianceGenome:MGI:96217
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HPGRT; Hprt1
Summary
The protein encoded by this gene is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides through the purine salvage pathway. [provided by RefSeq, Sep 2015]
Expression
Ubiquitous expression in liver E14 (RPKM 48.8), cerebellum adult (RPKM 42.3) and 27 other tissues See more
Orthologs
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Genomic context

See Hprt in Genome Data Viewer
Location:
X A5; X 29.31 cM
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (52076955..52110537)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (52988078..53021660)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene ribosomal protein S2, pseudogene 13 Neighboring gene PHD finger protein 6 Neighboring gene microRNA 450-1 Neighboring gene microRNA 450b

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC103149

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables guanine phosphoribosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables guanine phosphoribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables hypoxanthine phosphoribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hypoxanthine phosphoribosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables hypoxanthine phosphoribosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables hypoxanthine phosphoribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables magnesium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in AMP salvage IDA
Inferred from Direct Assay
more info
PubMed 
involved_in GMP catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in GMP salvage IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within GMP salvage IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in GMP salvage IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in GMP salvage ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in IMP metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in IMP salvage IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in IMP salvage IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within T cell mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
 
acts_upstream_of_or_within adenine metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within central nervous system neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cerebral cortex neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within dopamine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within dopaminergic neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT acts_upstream_of_or_within grooming behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within grooming behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in guanine salvage IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in guanine salvage ISO
Inferred from Sequence Orthology
more info
 
involved_in hypoxanthine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within hypoxanthine metabolic process IC
Inferred by Curator
more info
 
acts_upstream_of_or_within hypoxanthine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hypoxanthine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in hypoxanthine salvage ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 
acts_upstream_of_or_within lymphocyte proliferation IMP
Inferred from Mutant Phenotype
more info
 
involved_in positive regulation of dopamine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein homotetramerization ISO
Inferred from Sequence Orthology
more info
 
involved_in purine nucleotide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within purine ribonucleoside salvage IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within purine ribonucleoside salvage IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in purine ribonucleoside salvage ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to amphetamine IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within striatum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
hypoxanthine-guanine phosphoribosyltransferase
Names
HGPRT
HGPRTase
HPRT B
hypoxanthine guanine phosphoribosyl transferase 1
NP_038584.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013556.2NP_038584.2  hypoxanthine-guanine phosphoribosyltransferase

    See identical proteins and their annotated locations for NP_038584.2

    Status: REVIEWED

    Source sequence(s)
    AK002286, AK146626, BY285280
    Consensus CDS
    CCDS40972.1
    UniProtKB/Swiss-Prot
    P00493, Q545Y2
    Related
    ENSMUSP00000026723.9, ENSMUST00000026723.9
    Conserved Domains (1) summary
    cl00309
    Location:6218
    PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    52076955..52110537
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)