U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hpgd hydroxyprostaglandin dehydrogenase 15 (NAD) [ Mus musculus (house mouse) ]

Gene ID: 15446, updated on 8-Feb-2024

Summary

Official Symbol
Hpgdprovided by MGI
Official Full Name
hydroxyprostaglandin dehydrogenase 15 (NAD)provided by MGI
Primary source
MGI:MGI:108085
See related
Ensembl:ENSMUSG00000031613 AllianceGenome:MGI:108085
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
15-PGDH
Summary
Enables 15-hydroxyprostaglandin dehydrogenase (NAD+) activity. Involved in ductus arteriosus closure. Located in basolateral plasma membrane. Is expressed in several structures, including alimentary system; choroid plexus; humerus cartilage condensation; nose; and urinary system. Human ortholog(s) of this gene implicated in colon carcinoma and primary hypertrophic osteoarthropathy. Orthologous to human HPGD (15-hydroxyprostaglandin dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 76.0), bladder adult (RPKM 50.8) and 17 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Hpgd in Genome Data Viewer
Location:
8 B2; 8 29.7 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (56747587..56774081)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (56294552..56321046)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene a disintegrin and metallopeptidase domain 29 Neighboring gene glycine receptor, alpha 3 subunit Neighboring gene ribosomal protein S7 pseudogene Neighboring gene STARR-seq mESC enhancer starr_21512 Neighboring gene STARR-seq mESC enhancer starr_21513 Neighboring gene STARR-seq mESC enhancer starr_21514 Neighboring gene STARR-seq mESC enhancer starr_21515 Neighboring gene STARR-seq mESC enhancer starr_21516 Neighboring gene STARR-seq mESC enhancer starr_21517 Neighboring gene RIKEN cDNA 4930518J21 gene Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC14001

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 15-hydroxyicosatetraenoate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
enables 15-hydroxyprostaglandin dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 15-hydroxyprostaglandin dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 15-hydroxyprostaglandin dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
 
enables NAD binding ISO
Inferred from Sequence Orthology
more info
 
enables NAD+ binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ISO
Inferred from Sequence Orthology
more info
 
enables prostaglandin E receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in ductus arteriosus closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in female pregnancy IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in female pregnancy ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in parturition ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in prostaglandin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in prostaglandin metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of prostaglandin catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in response to ethanol ISO
Inferred from Sequence Orthology
more info
 
involved_in transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Names
15-hydroxyprostaglandin dehydrogenase
PGDH
eicosanoid/docosanoid dehydrogenase
prostaglandin dehydrogenase 1
NP_032304.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008278.2NP_032304.2  15-hydroxyprostaglandin dehydrogenase [NAD(+)]

    See identical proteins and their annotated locations for NP_032304.2

    Status: VALIDATED

    Source sequence(s)
    AK146038, BB870447, BY581851
    Consensus CDS
    CCDS40341.1
    UniProtKB/Swiss-Prot
    Q61106, Q8VCC1
    Related
    ENSMUSP00000034026.9, ENSMUST00000034026.10
    Conserved Domains (1) summary
    cd05323
    Location:6254
    ADH_SDR_c_like; insect type alcohol dehydrogenase (ADH)-like, classical (c) SDRs

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    56747587..56774081
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)