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Hpgd hydroxyprostaglandin dehydrogenase 15 (NAD) [ Mus musculus (house mouse) ]

Gene ID: 15446, updated on 12-Aug-2019

Summary

Official Symbol
Hpgdprovided by MGI
Official Full Name
hydroxyprostaglandin dehydrogenase 15 (NAD)provided by MGI
Primary source
MGI:MGI:108085
See related
Ensembl:ENSMUSG00000031613
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
15-PGDH; AV026552
Expression
Broad expression in lung adult (RPKM 76.0), bladder adult (RPKM 50.8) and 17 other tissues See more
Orthologs

Genomic context

See Hpgd in Genome Data Viewer
Location:
8; 8 B2
Exon count:
7
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (56294552..56321046)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (58773349..58799843)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene a disintegrin and metallopeptidase domain 29 Neighboring gene glycine receptor, alpha 3 subunit Neighboring gene ribosomal protein S7 pseudogene Neighboring gene RIKEN cDNA 4930518J21 gene Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Clone Names

  • MGC14001

Gene Ontology Provided by MGI

Function Evidence Code Pubs
15-hydroxyprostaglandin dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
15-hydroxyprostaglandin dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
PubMed 
15-hydroxyprostaglandin dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
 
NAD binding ISO
Inferred from Sequence Orthology
more info
 
NAD+ binding ISO
Inferred from Sequence Orthology
more info
 
catalytic activity ISO
Inferred from Sequence Orthology
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
prostaglandin E receptor activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
ductus arteriosus closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
female pregnancy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
female pregnancy ISO
Inferred from Sequence Orthology
more info
 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
parturition ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vascular smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
prostaglandin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
prostaglandin metabolic process ISO
Inferred from Sequence Orthology
more info
 
response to ethanol ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Names
15-hydroxyprostaglandin dehydrogenase
PGDH
prostaglandin dehydrogenase 1
NP_032304.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008278.2NP_032304.2  15-hydroxyprostaglandin dehydrogenase [NAD(+)]

    See identical proteins and their annotated locations for NP_032304.2

    Status: VALIDATED

    Source sequence(s)
    AK146038, BB870447, BY581851
    Consensus CDS
    CCDS40341.1
    UniProtKB/Swiss-Prot
    Q8VCC1
    Related
    ENSMUSP00000034026.8, ENSMUST00000034026.9
    Conserved Domains (2) summary
    cd05323
    Location:6254
    ADH_SDR_c_like; insect type alcohol dehydrogenase (ADH)-like, classical (c) SDRs
    pfam00106
    Location:6199
    adh_short; short chain dehydrogenase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p6 C57BL/6J

    Range
    56294552..56321046
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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