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Hpca hippocalcin [ Mus musculus (house mouse) ]

Gene ID: 15444, updated on 9-Mar-2023

Summary

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Official Symbol
Hpcaprovided by MGI
Official Full Name
hippocalcinprovided by MGI
Primary source
MGI:MGI:1336200
See related
Ensembl:ENSMUSG00000028785 AllianceGenome:MGI:1336200
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable several functions, including actin binding activity; calcium ion binding activity; and identical protein binding activity. Acts upstream of or within inner ear development. Predicted to be located in several cellular components, including dendrite; neuronal cell body membrane; and perikaryon. Predicted to be extrinsic component of membrane. Is expressed in ganglia and telencephalon. Human ortholog(s) of this gene implicated in torsion dystonia 2. Orthologous to human HPCA (hippocalcin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 184.5), frontal lobe adult (RPKM 103.2) and 3 other tissues See more
Orthologs
human all
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Genomic context

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See Hpca in Genome Data Viewer
Location:
4; 4 D2.2
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (129005363..129019712, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (129111570..129125919, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene adenylate kinase 2 Neighboring gene RIKEN cDNA 1700086P04 gene Neighboring gene ring finger protein 19B Neighboring gene transmembrane protein 54 Neighboring gene fibronectin type III domain containing 5 Neighboring gene S100P binding protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Proteomic identification of hippocalcin and its protective role in heatstroke-induced hypothalamic injury in mice. Ji J, et al. J Cell Physiol, 2019 Apr. PMID 30256386
  2. 7,8-Dihydroxy-4-methylcoumarin provides neuroprotection by increasing hippocalcin expression. Jin X, et al. Neurotox Res, 2015 Apr. PMID 25752619
  3. Hippocalcin and KCNQ channels contribute to the kinetics of the slow afterhyperpolarization. Kim KS, et al. Biophys J, 2012 Dec 19. PMID 23260046, Free PMC Article
  4. Hippocalcin gates the calcium activation of the slow afterhyperpolarization in hippocampal pyramidal cells. Tzingounis AV, et al. Neuron, 2007 Feb 15. PMID 17296551, Free PMC Article
  5. Hippocalcin protects hippocampal neurons against excitotoxin damage by enhancing calcium extrusion. Masuo Y, et al. Neuroscience, 2007 Mar 16. PMID 17257765

See all (39) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hippocalcin hasa protective role in heatstroke-induced hypothalamic injury in mice.
    Title: Proteomic identification of hippocalcin and its protective role in heatstroke-induced hypothalamic injury in mice.
  2. neurogenic markers, including doublecortin and the neuronal nuclei antigen, and hippocalcin, otub1, and spectrin-alpha are potential molecular links between hippocampal neurogenesis and exercise in the elderly.
    Title: Moderate-Intensity Exercise Induces Neurogenesis and Improves Cognition in Old Mice by Upregulating Hippocampal Hippocalcin, Otub1, and Spectrin-α.
  3. results suggest that 7,8-Dihydroxy-4-methylcoumarin prevents glutamate-induced toxicity by scavenging free radicals and regulating hippocalcin expression.
    Title: 7,8-Dihydroxy-4-methylcoumarin provides neuroprotection by increasing hippocalcin expression.
  4. Hippocalcin and KCNQ channels contribute to the kinetics of the slow afterhyperpolarization
    Title: Hippocalcin and KCNQ channels contribute to the kinetics of the slow afterhyperpolarization.
  5. Suggest that the maintenance of parvalbumin and hippocalcin levels by melatonin in ischemic injury contributes to the neuroprotective effect of melatonin against neuronal cell damage.
    Title: Melatonin regulates the calcium-buffering proteins, parvalbumin and hippocalcin, in ischemic brain injury.
  6. An age-dependent increase in neurodegeneration occurred in the gene-deleted mice, showing that hippocalcin contributes to neuronal viability during aging.
    Title: Hippocalcin protects against caspase-12-induced and age-dependent neuronal degeneration.
  7. These results suggest that hippocalcin plays a crucial role in the Ca(2+)-signaling pathway that underlies long-lasting neural plasticity and that leads to spatial and associative memory.
    Title: Hippocalcin-deficient mice display a defect in cAMP response element-binding protein activation associated with impaired spatial and associative memory.
  8. These results suggest that hippocalcin plays an important role in calcium extrusion from neurons and, in turn, helps to protect them against calcium-dependent excitotoxin damage in the hippocampus.
    Title: Hippocalcin protects hippocampal neurons against excitotoxin damage by enhancing calcium extrusion.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation of phospholipase D activity ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to L-glutamate ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to calcium ion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within inner ear development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of guanylate cyclase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of phospholipase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein targeting to membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynaptic neurotransmitter receptor internalization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite membrane ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic spine head ISO
Inferred from Sequence Orthology
more info
  
located_in extrinsic component of membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body membrane ISO
Inferred from Sequence Orthology
more info
  
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
neuron-specific calcium-binding protein hippocalcin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130419.2 → NP_001123891.1  neuron-specific calcium-binding protein hippocalcin

    See identical proteins and their annotated locations for NP_001123891.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AI835374, BC058588, BY128037, BY769297, CX240757
    Consensus CDS
    CCDS18682.1
    UniProtKB/Swiss-Prot
    P84075
    UniProtKB/TrEMBL
    A0A6P5PIL0, A0A8C6G9V9
    Related
    ENSMUSP00000129548.2, ENSMUST00000164649.8
    Conserved Domains (1) summary
    COG5126
    Location:13 → 179
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  2. NM_001286081.1 → NP_001273010.1  neuron-specific calcium-binding protein hippocalcin

    See identical proteins and their annotated locations for NP_001273010.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AI835374, BC058588, CX238650, CX239660
    Consensus CDS
    CCDS18682.1
    UniProtKB/Swiss-Prot
    P84075
    UniProtKB/TrEMBL
    A0A6P5PIL0, A0A8C6G9V9
    Related
    ENSMUSP00000119178.3, ENSMUST00000139450.8
    Conserved Domains (1) summary
    COG5126
    Location:13 → 179
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  3. NM_001286083.1 → NP_001273012.1  neuron-specific calcium-binding protein hippocalcin

    See identical proteins and their annotated locations for NP_001273012.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AI835374, BC058588, CX240088
    Consensus CDS
    CCDS18682.1
    UniProtKB/Swiss-Prot
    P84075
    UniProtKB/TrEMBL
    A0A6P5PIL0, A0A8C6G9V9
    Related
    ENSMUSP00000112143.3, ENSMUST00000116442.9
    Conserved Domains (1) summary
    COG5126
    Location:13 → 179
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  4. NM_010471.4 → NP_034601.1  neuron-specific calcium-binding protein hippocalcin

    See identical proteins and their annotated locations for NP_034601.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AI835374, AK002992, BC058588, BY129411
    Consensus CDS
    CCDS18682.1
    UniProtKB/Swiss-Prot
    P84075
    UniProtKB/TrEMBL
    A0A6P5PIL0, A0A8C6G9V9
    Related
    ENSMUSP00000030572.4, ENSMUST00000030572.10
    Conserved Domains (1) summary
    COG5126
    Location:13 → 179
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    129005363..129019712 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253224.1 → XP_030109084.1  neuron-specific calcium-binding protein hippocalcin isoform X1

    UniProtKB/TrEMBL
    A0A6P5PIL0, A0A8C6G9V9
    Conserved Domains (1) summary
    COG5126
    Location:13 → 179
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  2. XM_030253226.1 → XP_030109086.1  neuron-specific calcium-binding protein hippocalcin isoform X1

    UniProtKB/TrEMBL
    A0A6P5PIL0, A0A8C6G9V9
    Conserved Domains (1) summary
    COG5126
    Location:13 → 179
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  3. XM_030253227.1 → XP_030109087.1  neuron-specific calcium-binding protein hippocalcin isoform X1

    UniProtKB/TrEMBL
    A0A6P5PIL0, A0A8C6G9V9
    Conserved Domains (1) summary
    COG5126
    Location:13 → 179
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  4. XM_006502776.5 → XP_006502839.1  neuron-specific calcium-binding protein hippocalcin isoform X1

    See identical proteins and their annotated locations for XP_006502839.1

    UniProtKB/Swiss-Prot
    P84075
    UniProtKB/TrEMBL
    A0A6P5PIL0, A0A8C6G9V9
    Conserved Domains (1) summary
    COG5126
    Location:13 → 179
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  5. XM_006502775.4 → XP_006502838.1  neuron-specific calcium-binding protein hippocalcin isoform X1

    See identical proteins and their annotated locations for XP_006502838.1

    UniProtKB/Swiss-Prot
    P84075
    UniProtKB/TrEMBL
    A0A6P5PIL0, A0A8C6G9V9
    Related
    ENSMUSP00000112145.3, ENSMUST00000116444.10
    Conserved Domains (1) summary
    COG5126
    Location:13 → 179
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  6. XM_030253225.1 → XP_030109085.1  neuron-specific calcium-binding protein hippocalcin isoform X1

    UniProtKB/TrEMBL
    A0A6P5PIL0, A0A8C6G9V9
    Conserved Domains (1) summary
    COG5126
    Location:13 → 179
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  7. XM_006502777.3 → XP_006502840.1  neuron-specific calcium-binding protein hippocalcin isoform X1

    See identical proteins and their annotated locations for XP_006502840.1

    UniProtKB/Swiss-Prot
    P84075
    UniProtKB/TrEMBL
    A0A6P5PIL0, A0A8C6G9V9
    Conserved Domains (1) summary
    COG5126
    Location:13 → 179
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P84075.2 GenPept UniProtKB/Swiss-Prot:P84075

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