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Hpse heparanase [ Mus musculus (house mouse) ]

Gene ID: 15442, updated on 5-Jan-2023

Summary

Official Symbol
Hpseprovided by MGI
Official Full Name
heparanaseprovided by MGI
Primary source
MGI:MGI:1343124
See related
Ensembl:ENSMUSG00000035273 AllianceGenome:MGI:1343124
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hpa; HSE1; Hpr1
Summary
This gene encodes an endoglucuronidase enzyme that plays an important role in tumor invasion and metastasis. The encoded preproprotein undergoes proteolytic processing to generate an active heterodimeric enzyme that cleaves the heparan sulfate proteoglycans associated with the cell surface and extracellular matrix. Mice lacking the encoded protein do not show any prominent pathological alterations under normal conditions but fail to develop albuminuria and renal damage in response to drug-induced diabetes. [provided by RefSeq, Aug 2016]
Expression
Broad expression in spleen adult (RPKM 5.5), colon adult (RPKM 5.1) and 25 other tissues See more
Orthologs
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Genomic context

See Hpse in Genome Data Viewer
Location:
5; 5 E4
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (100827350..100867582, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (100679484..100719716, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene placenta-specific 8 Neighboring gene coenzyme Q2 4-hydroxybenzoate polyprenyltransferase Neighboring gene predicted gene, 36619 Neighboring gene helicase, POLQ-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (6)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cargo receptor ligand activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables heparanase activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to heparanase activity ISO
Inferred from Sequence Orthology
more info
 
enables heparanase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
 
enables syndecan binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in Factor XII activation ISO
Inferred from Sequence Orthology
more info
 
involved_in angiogenesis involved in wound healing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in angiogenesis involved in wound healing IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of endothelial barrier IDA
Inferred from Direct Assay
more info
PubMed 
involved_in heparan sulfate proteoglycan catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in heparan sulfate proteoglycan catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in heparin metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in heparin metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood coagulation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of extracellular matrix disassembly NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of hair follicle development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of osteoblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of osteoblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase B signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular endothelial growth factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in protein transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in regulation of hair follicle development ISO
Inferred from Sequence Orthology
more info
 
involved_in response to organic substance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vascular wound healing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in wound healing IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in autophagosome NAS
Non-traceable Author Statement
more info
PubMed 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular matrix TAS
Traceable Author Statement
more info
PubMed 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
part_of heparanase complex ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in lysosomal lumen ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
heparanase
Names
endo-glucoronidase
endoglycosidase heparanase
NP_690016.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152803.5NP_690016.1  heparanase preproprotein

    See identical proteins and their annotated locations for NP_690016.1

    Status: REVIEWED

    Source sequence(s)
    AC161510, AK040471, BC099521, BY014662
    Consensus CDS
    CCDS19466.1
    UniProtKB/Swiss-Prot
    Q6YGZ1, Q8K3K3
    Related
    ENSMUSP00000044072.9, ENSMUST00000045617.15
    Conserved Domains (1) summary
    pfam03662
    Location:163362
    Glyco_hydro_79n; Glycosyl hydrolase family 79, N-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    100827350..100867582 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)