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CYP1A2 cytochrome P450 family 1 subfamily A member 2 [ Homo sapiens (human) ]

Gene ID: 1544, updated on 8-Jul-2021

Summary

Official Symbol
CYP1A2provided by HGNC
Official Full Name
cytochrome P450 family 1 subfamily A member 2provided by HGNC
Primary source
HGNC:HGNC:2596
See related
Ensembl:ENSG00000140505 MIM:124060
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CP12; CYPIA2; P3-450; P450(PA)
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward liver (RPKM 100.8) See more
Orthologs
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Genomic context

See CYP1A2 in Genome Data Viewer
Location:
15q24.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (74748845..74756607)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (75041186..75048948)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene enhancer of mRNA decapping 3 Neighboring gene CYP1A1 5' regulatory region Neighboring gene cytochrome P450 family 1 subfamily A member 1 Neighboring gene CYP1A2 5' regulatory region Neighboring gene enhancer downstream of CYP1A2 Neighboring gene microRNA 4513 Neighboring gene C-terminal Src kinase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Clozapine response
MedGen: CN077971 GeneReviews: Not available
Compare labs
Genome wide association study identified SNP on 15q24 associated with bladder cancer risk in Japanese population.
GeneReviews: Not available
Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM.
GeneReviews: Not available
Genome-wide association study identifies eight loci associated with blood pressure.
GeneReviews: Not available
Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption.
GeneReviews: Not available
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.
GeneReviews: Not available
Ondansetron response
MedGen: CN417142 GeneReviews: Not available
Compare labs
Sequence variants at CYP1A1-CYP1A2 and AHR associate with coffee consumption.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables aromatase activity IEA
Inferred from Electronic Annotation
more info
 
enables caffeine oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables demethylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables electron transfer activity TAS
Traceable Author Statement
more info
PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables estrogen 16-alpha-hydroxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables estrogen 2-hydroxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables heme binding IDA
Inferred from Direct Assay
more info
PubMed 
enables hydroperoxy icosatetraenoate dehydratase activity IEA
Inferred from Electronic Annotation
more info
 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 
enables monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables monooxygenase activity TAS
Traceable Author Statement
more info
 
enables oxidoreductase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in aflatoxin metabolic process TAS
Traceable Author Statement
more info
 
involved_in alkaloid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular respiration IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to cadmium ion IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to copper ion IEA
Inferred from Electronic Annotation
more info
 
involved_in cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in dibenzo-p-dioxin metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in drug catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in drug metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in electron transport chain IEA
Inferred from Electronic Annotation
more info
 
involved_in epoxygenase P450 pathway TAS
Traceable Author Statement
more info
 
involved_in estrogen metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in exogenous drug catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in heterocycle metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in hydrogen peroxide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in long-chain fatty acid biosynthetic process TAS
Traceable Author Statement
more info
 
involved_in lung development IEA
Inferred from Electronic Annotation
more info
 
involved_in methylation TAS
Traceable Author Statement
more info
 
involved_in monocarboxylic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in monoterpenoid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in omega-hydroxylase P450 pathway TAS
Traceable Author Statement
more info
 
involved_in oxidative demethylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in porphyrin-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in post-embryonic development IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in response to estradiol IEA
Inferred from Electronic Annotation
more info
 
involved_in response to immobilization stress IEA
Inferred from Electronic Annotation
more info
 
involved_in response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
involved_in retinol metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in retinol metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in steroid catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in toxin biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cytochrome P450 1A2
Names
P450 form 4
aryl hydrocarbon hydroxylase
cholesterol 25-hydroxylase
cytochrome P(3)450
cytochrome P450 4
cytochrome P450, family 1, subfamily A, polypeptide 2
cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2
cytochrome P450-P3
dioxin-inducible P3-450
flavoprotein-linked monooxygenase
hydroperoxy icosatetraenoate dehydratase
microsomal monooxygenase
xenobiotic monooxygenase
NP_000752.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_061543.1 RefSeqGene

    Range
    5001..12763
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1274

mRNA and Protein(s)

  1. NM_000761.5NP_000752.2  cytochrome P450 1A2

    See identical proteins and their annotated locations for NP_000752.2

    Status: REVIEWED

    Source sequence(s)
    AC091230, BC067424, KF459683
    Consensus CDS
    CCDS32293.1
    UniProtKB/Swiss-Prot
    P05177
    Related
    ENSP00000342007.4, ENST00000343932.5
    Conserved Domains (1) summary
    pfam00067
    Location:42500
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    74748845..74756607
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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