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Hp haptoglobin [ Mus musculus (house mouse) ]

Gene ID: 15439, updated on 11-Apr-2024

Summary

Official Symbol
Hpprovided by MGI
Official Full Name
haptoglobinprovided by MGI
Primary source
MGI:MGI:96211
See related
Ensembl:ENSMUSG00000031722 AllianceGenome:MGI:96211
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HP-1; preHP2
Summary
This gene encodes a plasma glycoprotein called haptoglobin that binds free hemoglobin. The encoded preproprotein undergoes proteolytic processing to generate alpha and beta subunits that form a disulfide-linked tetrameric protein that plays an important role in the sequestration and clearance of extracorpuscular hemoglobin. Mice lacking the encoded protein exhibit stunted development of lymphoid organs associated with lower counts of mature T and B cells in the blood and secondary lymphoid compartments. [provided by RefSeq, Aug 2016]
Expression
Biased expression in liver adult (RPKM 929.2), liver E18 (RPKM 861.9) and 6 other tissues See more
Orthologs
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Genomic context

Location:
8 D3; 8 57.11 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (110301760..110305804, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (109575128..109579172, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene DEAH-box helicase 38 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:112089480-112089589 Neighboring gene STARR-positive B cell enhancer ABC_E565 Neighboring gene thioredoxin-like 4B Neighboring gene predicted gene, 39247 Neighboring gene dihydroorotate dehydrogenase Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:112132543-112132726

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables antioxidant activity IEA
Inferred from Electronic Annotation
more info
 
enables hemoglobin binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within acute-phase response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within defense response to bacterium IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in liver development ISO
Inferred from Sequence Orthology
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in blood microparticle ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
part_of haptoglobin-hemoglobin complex ISO
Inferred from Sequence Orthology
more info
 
part_of spherical high-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329965.1NP_001316894.1  haptoglobin isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded protein (isoform 2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC125162, BY166781
  2. NM_017370.2NP_059066.1  haptoglobin isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_059066.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AC125162, AK152698, M96827
    Consensus CDS
    CCDS40470.1
    UniProtKB/Swiss-Prot
    Q61646
    UniProtKB/TrEMBL
    Q3UBS3
    Related
    ENSMUSP00000074436.7, ENSMUST00000074898.8
    Conserved Domains (3) summary
    smart00020
    Location:102340
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:103343
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00084
    Location:3386
    Sushi; Sushi repeat (SCR repeat)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    110301760..110305804 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)