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Hoxd8 homeobox D8 [ Mus musculus (house mouse) ]

Gene ID: 15437, updated on 26-Sep-2022

Summary

Official Symbol
Hoxd8provided by MGI
Official Full Name
homeobox D8provided by MGI
Primary source
MGI:MGI:96209
See related
Ensembl:ENSMUSG00000027102 AllianceGenome:MGI:96209
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hox-4.3; Hox-5.4; 4921540P06Rik
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within anterior/posterior pattern specification; negative regulation of transcription by RNA polymerase II; and skeletal system morphogenesis. Predicted to be active in nucleus. Is expressed in several structures, including embryo mesenchyme; genitourinary system; hindlimb bud; limb; and nervous system. Orthologous to human HOXD8 (homeobox D8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in genital fat pad adult (RPKM 25.2), ovary adult (RPKM 21.0) and 10 other tissues See more
Orthologs
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Genomic context

See Hoxd8 in Genome Data Viewer
Location:
2 C3; 2 44.13 cM
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (74534959..74538277)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (74704615..74707933)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene homeobox D11 Neighboring gene homeobox D10 Neighboring gene homeobox D9 Neighboring gene predicted gene, 38462 Neighboring gene homeobox D3, opposite strand 1 Neighboring gene homeobox D3 Neighboring gene homeobox D4 Neighboring gene microRNA 10b

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
homeobox protein Hox-D8
Names
homeo box D8
homeobox protein Hox-4.3
homeobox protein Hox-5.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290730.2NP_001277659.1  homeobox protein Hox-D8 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' terminal exon, compared to variant 1, resulting in an isoform (b) that is 1 aa shorter than isoform a.
    Source sequence(s)
    AL928644
    Consensus CDS
    CCDS71077.1
    UniProtKB/TrEMBL
    A2ASN1, Q9CUH8, Q9CUQ8
    Related
    ENSMUSP00000088094.5, ENSMUST00000074721.6
    Conserved Domains (2) summary
    smart00389
    Location:194250
    HOX; Homeodomain
    COG5576
    Location:139271
    COG5576; Homeodomain-containing transcription factor [Transcription]
  2. NM_001290731.2NP_001277660.1  homeobox protein Hox-D8 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AL928644
    Consensus CDS
    CCDS79809.1
    UniProtKB/TrEMBL
    F6W963
    Related
    ENSMUSP00000118904.3, ENSMUST00000151380.2
    Conserved Domains (1) summary
    pfam00046
    Location:1769
    Homeobox; Homeobox domain
  3. NM_008276.4NP_032302.2  homeobox protein Hox-D8 isoform a

    See identical proteins and their annotated locations for NP_032302.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AL928644
    Consensus CDS
    CCDS16143.1
    UniProtKB/Swiss-Prot
    A2ASN2, P23463
    UniProtKB/TrEMBL
    Q9CUH8
    Related
    ENSMUSP00000019749.4, ENSMUST00000019749.4
    Conserved Domains (2) summary
    COG5576
    Location:139272
    COG5576; Homeodomain-containing transcription factor [Transcription]
    pfam00046
    Location:199251
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    74534959..74538277
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)