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Hoxd10 homeobox D10 [ Mus musculus (house mouse) ]

Gene ID: 15430, updated on 5-Aug-2022

Summary

Official Symbol
Hoxd10provided by MGI
Official Full Name
homeobox D10provided by MGI
Primary source
MGI:MGI:96202
See related
Ensembl:ENSMUSG00000050368 AllianceGenome:MGI:96202
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hox-4.5; Hox-5.3; AI385591; AI874987
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including limb morphogenesis; neuron differentiation; and regionalization. Predicted to be located in cytoplasmic ribonucleoprotein granule; cytosol; and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and limb bud. Human ortholog(s) of this gene implicated in congenital vertical talus. Orthologous to human HOXD10 (homeobox D10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in limb E14.5 (RPKM 13.3), subcutaneous fat pad adult (RPKM 8.3) and 6 other tissues See more
Orthologs
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Genomic context

See Hoxd10 in Genome Data Viewer
Location:
2 C3; 2 44.13 cM
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (74514617..74525450)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (74684273..74695106)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (74530005..74533159)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene homeobox D13 Neighboring gene homeobox D12 Neighboring gene homeobox D11 Neighboring gene homeobox D9 Neighboring gene predicted gene, 38462 Neighboring gene homeobox D8

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within adult locomotory behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within anterior/posterior pattern specification IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic limb morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic skeletal system morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within forelimb morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within hindlimb morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neuromuscular process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within peripheral nervous system neuron development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within proximal/distal pattern formation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within single fertilization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within skeletal muscle tissue development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within skeletal system development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spinal cord motor neuron cell fate specification IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
homeobox protein Hox-D10
Names
homeo box D10
homeobox protein Hox-4.5
homeobox protein Hox-5.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013554.5NP_038582.2  homeobox protein Hox-D10

    See identical proteins and their annotated locations for NP_038582.2

    Status: VALIDATED

    Source sequence(s)
    AK134330, AL928644
    Consensus CDS
    CCDS16141.1
    UniProtKB/Swiss-Prot
    P28359, Q91WU9
    Related
    ENSMUSP00000062412.4, ENSMUST00000061745.5
    Conserved Domains (1) summary
    pfam00046
    Location:269322
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    74514617..74525450
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498789.3XP_006498852.1  homeobox protein Hox-D10 isoform X1

    Conserved Domains (1) summary
    pfam00046
    Location:339393
    Homeobox; Homeobox domain