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Hoxb6 homeobox B6 [ Mus musculus (house mouse) ]

Gene ID: 15414, updated on 12-May-2024

Summary

Official Symbol
Hoxb6provided by MGI
Official Full Name
homeobox B6provided by MGI
Primary source
MGI:MGI:96187
See related
Ensembl:ENSMUSG00000000690 AllianceGenome:MGI:96187
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hox-2.2
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within anterior/posterior pattern specification; embryonic skeletal system morphogenesis; and erythrocyte homeostasis. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; early conceptus; embryo mesenchyme; genitourinary system; and gut. Orthologous to human HOXB6 (homeobox B6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in adrenal adult (RPKM 86.7), genital fat pad adult (RPKM 63.3) and 10 other tissues See more
Orthologs
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Genomic context

See Hoxb6 in Genome Data Viewer
Location:
11 D; 11 59.82 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (96183647..96192395)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (96292814..96301569)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene homeobox B8 Neighboring gene STARR-seq mESC enhancer starr_30545 Neighboring gene homeobox B7 Neighboring gene homeobox B5 and homeobox B6, opposite strand Neighboring gene homeobox B5 Neighboring gene homeobox B3 Neighboring gene Hoxb locus associated lincRNA Neighboring gene microRNA 10a

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
homeobox protein Hox-B6
Names
homeo box B6
homeobox protein Hox-2.2
homeobox protein MH-22A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008269.2NP_032295.1  homeobox protein Hox-B6

    See identical proteins and their annotated locations for NP_032295.1

    Status: VALIDATED

    Source sequence(s)
    AL645478, BE948571
    Consensus CDS
    CCDS25295.1
    UniProtKB/Swiss-Prot
    P09023
    Related
    ENSMUSP00000000704.4, ENSMUST00000000704.6
    Conserved Domains (1) summary
    pfam00046
    Location:150203
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    96183647..96192395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532292.5XP_006532355.1  homeobox protein Hox-B6 isoform X1

    Conserved Domains (1) summary
    pfam00046
    Location:235288
    Homeobox; Homeobox domain