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Hoxb4 homeobox B4 [ Mus musculus (house mouse) ]

Gene ID: 15412, updated on 26-Sep-2022

Summary

Official Symbol
Hoxb4provided by MGI
Official Full Name
homeobox B4provided by MGI
Primary source
MGI:MGI:96185
See related
Ensembl:ENSMUSG00000038692 AllianceGenome:MGI:96185
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hox-2.6
Summary
Enables DNA binding activity. Acts upstream of or within several processes, including embryonic skeletal system morphogenesis; hematopoietic or lymphoid organ development; and somatic stem cell division. Predicted to be located in centrosome and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including embryo mesenchyme; genitourinary system; gut; nervous system; and skin. Orthologous to human HOXB4 (homeobox B4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 14.0), genital fat pad adult (RPKM 8.9) and 16 other tissues See more
Orthologs
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Genomic context

See Hoxb4 in Genome Data Viewer
Location:
11 D; 11 59.83 cM
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (96209093..96212464)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (96318267..96321638)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene homeobox B5 and homeobox B6, opposite strand Neighboring gene homeobox B5 Neighboring gene homeobox B3 Neighboring gene microRNA 10a Neighboring gene homeobox B3 and homeobox B2, opposite strand Neighboring gene homeobox B2 Neighboring gene homeobox B1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (9)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in anterior/posterior pattern specification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within anterior/posterior pattern specification IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within bone marrow development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within definitive hemopoiesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in embryonic skeletal system morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within embryonic skeletal system morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in hematopoietic stem cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hematopoietic stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within morphogenesis of an epithelial sheet IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of stem cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within skeletal system morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within skeletal system morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within somatic stem cell division IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within spleen development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
homeobox protein Hox-B4
Names
homeo box B4
homeobox protein Hox-2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010459.7NP_034589.3  homeobox protein Hox-B4

    See identical proteins and their annotated locations for NP_034589.3

    Status: VALIDATED

    Source sequence(s)
    AL606824
    Consensus CDS
    CCDS25297.1
    UniProtKB/Swiss-Prot
    P10284, Q4VBG0
    UniProtKB/TrEMBL
    A0A6P5QKV0, A0A8C6HHK1
    Related
    ENSMUSP00000048002.8, ENSMUST00000049241.9
    Conserved Domains (1) summary
    pfam00046
    Location:164218
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    96209093..96212464
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)