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RAET1L retinoic acid early transcript 1L [ Homo sapiens (human) ]

Gene ID: 154064, updated on 2-Apr-2023


Official Symbol
RAET1Lprovided by HGNC
Official Full Name
retinoic acid early transcript 1Lprovided by HGNC
Primary source
See related
Ensembl:ENSG00000155918 MIM:611047; AllianceGenome:HGNC:16798
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAET1L belongs to the RAET1 family of major histocompatibility complex (MHC) class I-related genes, which are located within a 180-kb cluster on chromosome 6q24.2-q25.3. The REAT1 genes encode glycoproteins that contain extracellular alpha-1 and alpha-2 domains, but they lack the membrane proximal Ig-like alpha-3 domain. Most RAET1 glycoproteins are anchored to the membrane via glycosylphosphatidylinositol (GPI) linkage (Radosavljevic et al., 2002 [PubMed 11827464]).[supplied by OMIM, Mar 2008]
Biased expression in esophagus (RPKM 15.6) and skin (RPKM 1.0) See more
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Genomic context

See RAET1L in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (150018334..150025532, complement)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (151217707..151224927, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (150339470..150346668, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene retinoic acid early transcript 1K pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:150327472-150328187 Neighboring gene retinoic acid early transcript 1M pseudogene Neighboring gene PHB1 pseudogene 1

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 (SF2) Nef downregulates RAET1L (ULBP6); downregulation is dependent upon residues G2 and F195 and a di-lysine motif in Nef as shown in A3.01 T cells and HeLa TZM-bl cells PubMed
Vpu vpu HIV-1 (NL4-3) Vpu downregulates RAET1L (ULBP6); downregulation is dependent upon amino acids R30/K31, V25/Y29, the acidic di-leucine motif in Vpu helix 2 as shown in A3.01 T cells and HeLa TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database


Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
UL16-binding protein 6
UL16 binding protein 6
retinoic acid early transcript 1H
retinoic acid early transcript 1L protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130900.3NP_570970.2  UL16-binding protein 6 precursor

    See identical proteins and their annotated locations for NP_570970.2

    Status: VALIDATED

    Source sequence(s)
    AL355497, AY039682, DA442768
    Consensus CDS
    Q5VY80, Q8TE74
    ENSP00000356310.1, ENST00000367341.6
    Conserved Domains (1) summary
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    150018334..150025532 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0


  1. NC_060930.1 Alternate T2T-CHM13v2.0

    151217707..151224927 complement
    GenBank, FASTA, Sequence Viewer (Graphics)