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CNKSR3 CNKSR family member 3 [ Homo sapiens (human) ]

Gene ID: 154043, updated on 18-Nov-2018

Summary

Official Symbol
CNKSR3provided by HGNC
Official Full Name
CNKSR family member 3provided by HGNC
Primary source
HGNC:HGNC:23034
See related
Ensembl:ENSG00000153721 MIM:617476; Vega:OTTHUMG00000015873
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CNK3; MAGI1; CNK3/IPCEF1
Expression
Ubiquitous expression in esophagus (RPKM 6.3), kidney (RPKM 5.3) and 24 other tissues See more
Orthologs

Genomic context

See CNKSR3 in Genome Data Viewer
Location:
6q25.2
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (154405147..154510659, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (154726433..154831753, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene opioid receptor mu 1 Neighboring gene interaction protein for cytohesin exchange factors 1 Neighboring gene ribosomal protein L17 pseudogene 24 Neighboring gene uncharacterized LOC105378067 Neighboring gene uncharacterized LOC101928868 Neighboring gene chromosome 6 open reading frame 203 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.
NHGRI GWA Catalog
Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31349

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of peptidyl-serine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cellular response to hepatocyte growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of sodium ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of sodium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
connector enhancer of kinase suppressor of ras 3
Names
CNK homolog protein 3
connector enhancer of KSR 3
maguin-like protein
membrane associated guanylate kinase, WW and PDZ domain containing 1
membrane-associated guanylate kinase-interacting protein-like 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173515.3NP_775786.2  connector enhancer of kinase suppressor of ras 3

    See identical proteins and their annotated locations for NP_775786.2

    Status: VALIDATED

    Source sequence(s)
    AK055911, AY328892, AY328893, BC060761
    Consensus CDS
    CCDS5246.1
    UniProtKB/Swiss-Prot
    Q6P9H4
    Related
    ENSP00000475915.1, OTTHUMP00000017466, ENST00000607772.5, OTTHUMT00000042792
    Conserved Domains (4) summary
    cd09511
    Location:472
    SAM_CNK1,2,3-suppressor; SAM domain of CNK1,2,3-suppressor subfamily
    pfam06663
    Location:334545
    DUF1170; Protein of unknown function (DUF1170)
    pfam10534
    Location:80171
    CRIC_ras_sig; Connector enhancer of kinase suppressor of ras
    cl00117
    Location:221305
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    154405147..154510659 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535485.3XP_011533787.1  connector enhancer of kinase suppressor of ras 3 isoform X1

    Conserved Domains (5) summary
    cd09511
    Location:862
    SAM_CNK1,2,3-suppressor; SAM domain of CNK1,2,3-suppressor subfamily
    smart00454
    Location:1359
    SAM; Sterile alpha motif
    pfam06663
    Location:324535
    DUF1170; Protein of unknown function (DUF1170)
    pfam10534
    Location:70161
    CRIC_ras_sig; Connector enhancer of kinase suppressor of ras
    cl00117
    Location:211295
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
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