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ADRB2 adrenoceptor beta 2 [ Homo sapiens (human) ]

Gene ID: 154, updated on 17-May-2020

Summary

Official Symbol
ADRB2provided by HGNC
Official Full Name
adrenoceptor beta 2provided by HGNC
Primary source
HGNC:HGNC:286
See related
Ensembl:ENSG00000169252 MIM:109690
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BAR; B2AR; ADRBR; ADRB2R; BETA2AR
Summary
This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This receptor is also a transcription regulator of the alpha-synuclein gene, and together, both genes are believed to be associated with risk of Parkinson's Disease. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity, type 2 diabetes and cardiovascular disease. [provided by RefSeq, Oct 2019]
Orthologs

Genomic context

See ADRB2 in Genome Data Viewer
Location:
5q32
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (148826611..148828623)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (148206156..148254628)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986462 Neighboring gene 5-hydroxytryptamine receptor 4 Neighboring gene uncharacterized LOC105378221 Neighboring gene SH3 domain and tetratricopeptide repeats 2 Neighboring gene RNA, U6 small nuclear 732, pseudogene Neighboring gene microRNA 584

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase binding IEA
Inferred from Electronic Annotation
more info
 
amyloid-beta binding IDA
Inferred from Direct Assay
more info
PubMed 
beta2-adrenergic receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
beta2-adrenergic receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
beta2-adrenergic receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
epinephrine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
norepinephrine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
norepinephrine binding IDA
Inferred from Direct Assay
more info
PubMed 
potassium channel regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
activation of adenylate cyclase activity IDA
Inferred from Direct Assay
more info
PubMed 
activation of transmembrane receptor protein tyrosine kinase activity TAS
Traceable Author Statement
more info
PubMed 
adenylate cyclase-activating adrenergic receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adrenergic receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
bone resorption IEA
Inferred from Electronic Annotation
more info
 
brown fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
cell-cell signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to amyloid-beta IGI
Inferred from Genetic Interaction
more info
PubMed 
desensitization of G protein-coupled receptor signaling pathway by arrestin IDA
Inferred from Direct Assay
more info
PubMed 
diet induced thermogenesis IEA
Inferred from Electronic Annotation
more info
 
endosome to lysosome transport TAS
Traceable Author Statement
more info
PubMed 
heat generation IEA
Inferred from Electronic Annotation
more info
 
membrane organization TAS
Traceable Author Statement
more info
 
negative regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
negative regulation of smooth muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of AMPA receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of autophagosome maturation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of bone mineralization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cAMP-dependent protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of lipophagy IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of mini excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein kinase A signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of protein serine/threonine kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
protein deubiquitination TAS
Traceable Author Statement
more info
 
receptor-mediated endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
regulation of sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
response to cold IEA
Inferred from Electronic Annotation
more info
 
response to psychosocial stress TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
clathrin-coated vesicle membrane TAS
Traceable Author Statement
more info
 
early endosome IEA
Inferred from Electronic Annotation
more info
 
endosome TAS
Traceable Author Statement
more info
PubMed 
endosome membrane TAS
Traceable Author Statement
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
lysosome TAS
Traceable Author Statement
more info
PubMed 
membrane NAS
Non-traceable Author Statement
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
beta-2 adrenergic receptor
Names
adrenergic, beta-2-, receptor, surface
adrenoceptor beta 2 surface
beta-2 adrenoceptor
beta-2 adrenoreceptor
catecholamine receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016421.2 RefSeqGene

    Range
    5019..7031
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000024.6NP_000015.2  beta-2 adrenergic receptor

    Status: REVIEWED

    Source sequence(s)
    AC011354, AK313151, BC073856, CA440083
    Consensus CDS
    CCDS4292.1
    Related
    ENSP00000305372.4, ENST00000305988.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    148826611..148828623
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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