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ADRB2 adrenoceptor beta 2 [ Homo sapiens (human) ]

Gene ID: 154, updated on 6-May-2021

Summary

Official Symbol
ADRB2provided by HGNC
Official Full Name
adrenoceptor beta 2provided by HGNC
Primary source
HGNC:HGNC:286
See related
Ensembl:ENSG00000169252 MIM:109690
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BAR; B2AR; ADRBR; ADRB2R; BETA2AR
Summary
This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This receptor is also a transcription regulator of the alpha-synuclein gene, and together, both genes are believed to be associated with risk of Parkinson's Disease. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity, type 2 diabetes and cardiovascular disease. [provided by RefSeq, Oct 2019]
Orthologs
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Genomic context

See ADRB2 in Genome Data Viewer
Location:
5q32
Exon count:
1
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (148826611..148828623)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (148206174..148208186)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986462 Neighboring gene 5-hydroxytryptamine receptor 4 Neighboring gene uncharacterized LOC105378221 Neighboring gene SH3 domain and tetratricopeptide repeats 2 Neighboring gene RNA, U6 small nuclear 732, pseudogene Neighboring gene microRNA 584

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables adenylate cyclase binding IEA
Inferred from Electronic Annotation
more info
 
enables amyloid-beta binding IDA
Inferred from Direct Assay
more info
PubMed 
enables beta2-adrenergic receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables beta2-adrenergic receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables beta2-adrenergic receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables norepinephrine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables norepinephrine binding IDA
Inferred from Direct Assay
more info
PubMed 
enables potassium channel regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in activation of adenylate cyclase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in activation of transmembrane receptor protein tyrosine kinase activity TAS
Traceable Author Statement
more info
PubMed 
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in adrenergic receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in bone resorption IEA
Inferred from Electronic Annotation
more info
 
involved_in brown fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in cellular response to amyloid-beta IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in desensitization of G protein-coupled receptor signaling pathway by arrestin IDA
Inferred from Direct Assay
more info
PubMed 
involved_in diet induced thermogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in endosome to lysosome transport TAS
Traceable Author Statement
more info
PubMed 
involved_in heat generation IEA
Inferred from Electronic Annotation
more info
 
involved_in membrane organization TAS
Traceable Author Statement
more info
 
involved_in negative regulation of inflammatory response to antigenic stimulus TAS
Traceable Author Statement
more info
 
involved_in negative regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of smooth muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of AMPA receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of autophagosome maturation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of bone mineralization IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cAMP-dependent protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of lipophagy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of mini excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein kinase A signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of protein serine/threonine kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in protein deubiquitination TAS
Traceable Author Statement
more info
 
involved_in receptor-mediated endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in response to cold IEA
Inferred from Electronic Annotation
more info
 
involved_in response to psychosocial stress TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in clathrin-coated endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
located_in early endosome IEA
Inferred from Electronic Annotation
more info
 
located_in endosome TAS
Traceable Author Statement
more info
PubMed 
located_in endosome membrane TAS
Traceable Author Statement
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome TAS
Traceable Author Statement
more info
PubMed 
located_in membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
beta-2 adrenergic receptor
Names
adrenergic, beta-2-, receptor, surface
adrenoceptor beta 2 surface
beta-2 adrenoceptor
beta-2 adrenoreceptor
catecholamine receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016421.2 RefSeqGene

    Range
    5019..7031
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000024.6NP_000015.2  beta-2 adrenergic receptor

    Status: REVIEWED

    Source sequence(s)
    AC011354, AK313151, BC073856, CA440083
    Consensus CDS
    CCDS4292.1
    Related
    ENSP00000305372.4, ENST00000305988.6
    Conserved Domains (1) summary
    cd15957
    Location:34336
    7tmA_Beta2_AR; beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    148826611..148828623
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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