ADRB2 adrenoceptor beta 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ADRB2provided by HGNC
Official Full Name: adrenoceptor beta 2provided by HGNC
Primary source: HGNC:HGNC:286
See related: Ensembl:ENSG00000169252 MIM:109690
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BAR; B2AR; ADRBR; ADRB2R; BETA2AR
Summary: This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This receptor is also a transcription regulator of the alpha-synuclein gene, and together, both genes are believed to be associated with risk of Parkinson's Disease. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity, type 2 diabetes and cardiovascular disease. [provided by RefSeq, Oct 2019]
Orthologs: mouse all
NEW: Try the new Data Table view

Genomic context

Location:: 5q32

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
109.20201120	current	GRCh38.p13 (GCF_000001405.39)	5	NC_000005.10 (148826611..148828623)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (148206156..148254628)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Influence of rs1042713 and rs1042714 polymorphisms of beta2-adrenergic receptor gene with erythrocyte cAMP in sickle cell disease patients from Odisha State, India.
Title: Influence of rs1042713 and rs1042714 polymorphisms of β2-adrenergic receptor gene with erythrocyte cAMP in sickle cell disease patients from Odisha State, India.
beta2AR-dependent signaling contributes to in-vivo reendothelialization capacity of endothelial progenitor cells by shear stress.
Title: β2AR-dependent signaling contributes to in-vivo reendothelialization capacity of endothelial progenitor cells by shear stress.
Association between the A46G polymorphism (rs1042713) in the beta2-adrenergic receptor gene and essential hypertension susceptibility in the Chinese population: A PRISMA-compliant meta-analysis.
Title: Association between the A46G polymorphism (rs1042713) in the β2-adrenergic receptor gene and essential hypertension susceptibility in the Chinese population: A PRISMA-compliant meta-analysis.
beta2 adrenergic interaction and cardiac autonomic function: effects of aerobic training in overweight/obese individuals.
Title: β<sub>2</sub> adrenergic interaction and cardiac autonomic function: effects of aerobic training in overweight/obese individuals.
Beta1- and Beta2-Adrenoceptors Expression Patterns in Human Non-small Cell Lung Cancer: Relationship with Cancer Histology.
Title: Beta1- and Beta2-Adrenoceptors Expression Patterns in Human Non-small Cell Lung Cancer: Relationship with Cancer Histology.
Molecular dynamics simulation of beta-adrenoceptors and their coupled G proteins.
Title: Molecular dynamics simulation of β-adrenoceptors and their coupled G proteins.
Chronic stress promotes gastric cancer progression and metastasis: an essential role for ADRB2.
Title: Chronic stress promotes gastric cancer progression and metastasis: an essential role for ADRB2.
Correlation study on beta2-adrenergic receptor gene polymorphisms and asthma susceptibility: evidence based on 57 case-control studies.
Title: Correlation study on β2-adrenergic receptor gene polymorphisms and asthma susceptibility: evidence based on 57 case-control studies.
BETA2AR expression was identified as a significant independent prognostic factor in patients with surgically resected colorectal cancer.
Title: Prognostic significance of β2-adrenergic receptor expression in patients with surgically resected colorectal cancer.
High ADRB2 expression is required for androgen-deprivation therapy (ADT)-induced Neuroendocrine transdifferentiation (NEtD), characterized by ADRB2 downregulation and treatment-related neuroendocrine prostate cancer (t-NEPC) emergence.
Title: The β<sub>2</sub>-Adrenergic Receptor Is a Molecular Switch for Neuroendocrine Transdifferentiation of Prostate Cancer Cells.

Submit: New GeneRIF Correction See all GeneRIFs (695)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Asthma, susceptibility to MedGen: C1869116 OMIM: 600807 GeneReviews: Not available	Compare labs
Obesity MedGen: C0028754 OMIM: 601665 GeneReviews: Not available	Compare labs

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

GDB:606222 (e-PCR)
- UniSTS:158215

GDB:606238 (e-PCR)
- UniSTS:158219

GDB:606265 (e-PCR)
- UniSTS:158222

ADRB2 (e-PCR)
- UniSTS:504882

PMC109640P1 (e-PCR)
- UniSTS:270173

ADRB2sts1 (e-PCR)
- UniSTS:258478

ADRB2 (e-PCR)
- UniSTS:265908

PMC115184P1 (e-PCR)
- UniSTS:270293

RH79898 (e-PCR)
- UniSTS:87528

GDB:294209 (e-PCR)
- UniSTS:156395

ADRB2_1263 (e-PCR)
- UniSTS:276979

ADRB2_v364 (e-PCR)
- UniSTS:276979

WI-19151 (e-PCR)
- UniSTS:65272

Homology

Homologs of the ADRB2 gene: The ADRB2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, and frog.
Orthologs from Annotation Pipeline: 327 organisms have orthologs with human gene ADRB2
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
adenylate cyclase binding	IEA Inferred from Electronic Annotation more info
amyloid-beta binding	IDA Inferred from Direct Assay more info	PubMed
beta2-adrenergic receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
beta2-adrenergic receptor activity	IDA Inferred from Direct Assay more info	PubMed
beta2-adrenergic receptor activity	NAS Non-traceable Author Statement more info	PubMed
identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
norepinephrine binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
norepinephrine binding	IDA Inferred from Direct Assay more info	PubMed
potassium channel regulator activity	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info
activation of adenylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
activation of transmembrane receptor protein tyrosine kinase activity	TAS Traceable Author Statement more info	PubMed
adenylate cyclase-activating adrenergic receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
adenylate cyclase-modulating G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
adrenergic receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
bone resorption	IEA Inferred from Electronic Annotation more info
brown fat cell differentiation	IEA Inferred from Electronic Annotation more info
cell surface receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
cellular response to amyloid-beta	IGI Inferred from Genetic Interaction more info	PubMed
desensitization of G protein-coupled receptor signaling pathway by arrestin	IDA Inferred from Direct Assay more info	PubMed
diet induced thermogenesis	IEA Inferred from Electronic Annotation more info
endosome to lysosome transport	TAS Traceable Author Statement more info	PubMed
heat generation	IEA Inferred from Electronic Annotation more info
membrane organization	TAS Traceable Author Statement more info
negative regulation of multicellular organism growth	IEA Inferred from Electronic Annotation more info
negative regulation of smooth muscle contraction	IBA Inferred from Biological aspect of Ancestor more info	PubMed
norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of AMPA receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
positive regulation of autophagosome maturation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of bone mineralization	IEA Inferred from Electronic Annotation more info
positive regulation of cAMP-dependent protein kinase activity	TAS Traceable Author Statement more info	PubMed
positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
positive regulation of lipophagy	IDA Inferred from Direct Assay more info	PubMed
positive regulation of mini excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
positive regulation of protein kinase A signaling	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of protein serine/threonine kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
protein deubiquitination	TAS Traceable Author Statement more info
receptor-mediated endocytosis	IDA Inferred from Direct Assay more info	PubMed
regulation of sodium ion transport	IEA Inferred from Electronic Annotation more info
response to cold	IEA Inferred from Electronic Annotation more info
response to psychosocial stress	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
apical plasma membrane	IEA Inferred from Electronic Annotation more info
clathrin-coated vesicle membrane	TAS Traceable Author Statement more info
early endosome	IEA Inferred from Electronic Annotation more info
endosome	TAS Traceable Author Statement more info	PubMed
endosome membrane	TAS Traceable Author Statement more info
integral component of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
integral component of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
lysosome	TAS Traceable Author Statement more info	PubMed
membrane	NAS Non-traceable Author Statement more info	PubMed
nucleus	IEA Inferred from Electronic Annotation more info
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	TAS Traceable Author Statement more info
receptor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: beta-2 adrenergic receptor

Names: adrenergic, beta-2-, receptor, surface; adrenoceptor beta 2 surface; beta-2 adrenoceptor; beta-2 adrenoreceptor; catecholamine receptor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Data Table view

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_016421.2 RefSeqGene

Range

5019..7031

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000024.6 → NP_000015.2 beta-2 adrenergic receptor

Status: REVIEWED

Source sequence(s)

AC011354, AK313151, BC073856, CA440083

Consensus CDS

CCDS4292.1

Related

ENSP00000305372.4, ENST00000305988.5

Conserved Domains (1) summary

cd15957
Location:34 → 336

7tmA_Beta2_AR; beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors