ADRB2 adrenoceptor beta 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ADRB2provided by HGNC
Official Full Name: adrenoceptor beta 2provided by HGNC
Primary source: HGNC:HGNC:286
See related: Ensembl:ENSG00000169252 MIM:109690; AllianceGenome:HGNC:286
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BAR; B2AR; ADRBR; ADRB2R; BETA2AR
Summary: This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This receptor is also a transcription regulator of the alpha-synuclein gene, and together, both genes are believed to be associated with risk of Parkinson's Disease. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity, type 2 diabetes and cardiovascular disease. [provided by RefSeq, Oct 2019]
Orthologs: mouse all
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Genomic context

Location:: 5q32

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
110	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (148826611..148828623)
110	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (149361444..149363456)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (148206174..148208186)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In silico identification of a beta2-adrenoceptor allosteric site that selectively augments canonical beta2AR-Gs signaling and function.
Title: In silico identification of a β2-adrenoceptor allosteric site that selectively augments canonical β2AR-Gs signaling and function.
ADRB2 expression predicts the clinical outcomes and is associated with immune cells infiltration in lung adenocarcinoma.
Title: ADRB2 expression predicts the clinical outcomes and is associated with immune cells infiltration in lung adenocarcinoma.
Single-nucleotide polymorphism of ADRbeta2 and CDKN1B genes in Egyptian patients with coronary artery in-stent restenosis.
Title: Single-nucleotide polymorphism of ADRβ2 and CDKN1B genes in Egyptian patients with coronary artery in-stent restenosis.
Beta 2-Adrenergic Receptor in Circulating Cancer-Associated Cells Predicts for Increases in Stromal Macrophages in Circulation and Patient Survival in Metastatic Breast Cancer.
Title: Beta 2-Adrenergic Receptor in Circulating Cancer-Associated Cells Predicts for Increases in Stromal Macrophages in Circulation and Patient Survival in Metastatic Breast Cancer.
Association between beta-2 adrenergic receptor variants and clinical outcomes in children and adolescents with acute asthma.
Title: Association between beta-2 adrenergic receptor variants and clinical outcomes in children and adolescents with acute asthma.
Beta 2 adrenergic receptor and mu opioid receptor interact to potentiate the aggressiveness of human breast cancer cell by activating the glycogen synthase kinase 3 signaling.
Title: Beta 2 adrenergic receptor and mu opioid receptor interact to potentiate the aggressiveness of human breast cancer cell by activating the glycogen synthase kinase 3 signaling.
Genetic biomarkers of life-threatening pheochromocytoma-induced cardiomyopathy.
Title: Genetic biomarkers of life-threatening pheochromocytoma-induced cardiomyopathy.
Effect of Beta 2-Adrenergic Receptor Gly16Arg Polymorphism on Taste Preferences in Healthy Young Japanese Adults.
Title: Effect of Beta 2-Adrenergic Receptor Gly16Arg Polymorphism on Taste Preferences in Healthy Young Japanese Adults.
Analysis of L-DOPA and droxidopa binding to human beta2-adrenergic receptor.
Title: Analysis of L-DOPA and droxidopa binding to human β2-adrenergic receptor.
ADRB2 gene influences responsiveness to physical exercise programs: A longitudinal study applied to overweight or obese Brazilian children and adolescents.
Title: ADRB2 gene influences responsiveness to physical exercise programs: A longitudinal study applied to overweight or obese Brazilian children and adolescents.

Submit: New GeneRIF Correction See all GeneRIFs (740)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Inherited susceptibility to asthma MedGen: C1869116 OMIM: 600807 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:606222 (e-PCR)
- UniSTS:158215

GDB:606238 (e-PCR)
- UniSTS:158219

GDB:606265 (e-PCR)
- UniSTS:158222

ADRB2 (e-PCR)
- UniSTS:504882

PMC109640P1 (e-PCR)
- UniSTS:270173

ADRB2sts1 (e-PCR)
- UniSTS:258478

ADRB2 (e-PCR)
- UniSTS:265908

PMC115184P1 (e-PCR)
- UniSTS:270293

RH79898 (e-PCR)
- UniSTS:87528

GDB:294209 (e-PCR)
- UniSTS:156395

ADRB2_1263 (e-PCR)
- UniSTS:276979

ADRB2_v364 (e-PCR)
- UniSTS:276979

WI-19151 (e-PCR)
- UniSTS:65272

Homology

Homologs of the ADRB2 gene: The ADRB2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, and frog.
Orthologs from Annotation Pipeline: 443 organisms have orthologs with human gene ADRB2
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables adenylate cyclase binding	IEA Inferred from Electronic Annotation more info
enables amyloid-beta binding	IDA Inferred from Direct Assay more info	PubMed
enables beta2-adrenergic receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables beta2-adrenergic receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables beta2-adrenergic receptor activity	NAS Non-traceable Author Statement more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables norepinephrine binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables norepinephrine binding	IDA Inferred from Direct Assay more info	PubMed
enables potassium channel regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in activation of adenylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in activation of transmembrane receptor protein tyrosine kinase activity	TAS Traceable Author Statement more info	PubMed
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in adrenergic receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in bone resorption	IEA Inferred from Electronic Annotation more info
involved_in brown fat cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to amyloid-beta	IGI Inferred from Genetic Interaction more info	PubMed
involved_in desensitization of G protein-coupled receptor signaling pathway by arrestin	IDA Inferred from Direct Assay more info	PubMed
involved_in diet induced thermogenesis	IEA Inferred from Electronic Annotation more info
involved_in endosome to lysosome transport	TAS Traceable Author Statement more info	PubMed
involved_in heat generation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of multicellular organism growth	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of smooth muscle contraction	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of AMPA receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of autophagosome maturation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of bone mineralization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cAMP-dependent protein kinase activity	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of lipophagy	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of mini excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein kinase A signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein serine/threonine kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in receptor-mediated endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of sodium ion transport	IEA Inferred from Electronic Annotation more info
involved_in response to cold	IEA Inferred from Electronic Annotation more info
involved_in response to psychosocial stress	TAS Traceable Author Statement more info	PubMed
involved_in smooth muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in clathrin-coated endocytic vesicle membrane	TAS Traceable Author Statement more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in endosome	TAS Traceable Author Statement more info	PubMed
located_in endosome membrane	TAS Traceable Author Statement more info
located_in lysosome	TAS Traceable Author Statement more info	PubMed
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
located_in neuronal dense core vesicle	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
part_of receptor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: beta-2 adrenergic receptor

Names: adrenergic, beta-2-, receptor, surface; adrenoceptor beta 2 surface; beta-2 adrenoceptor; beta-2 adrenoreceptor; catecholamine receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_016421.2 RefSeqGene

Range

5019..7031

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000024.6 → NP_000015.2 beta-2 adrenergic receptor

Status: REVIEWED

Source sequence(s)

AC011354, AK313151, BC073856, CA440083

Consensus CDS

CCDS4292.1

UniProtKB/Swiss-Prot

Q9UMZ5

UniProtKB/TrEMBL

X5DQM5

Related

ENSP00000305372.4, ENST00000305988.6

Conserved Domains (1) summary

cd15957
Location:34 → 336

7tmA_Beta2_AR; beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors