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Hoxa11 homeobox A11 [ Mus musculus (house mouse) ]

Gene ID: 15396, updated on 2-Oct-2018

Summary

Official Symbol
Hoxa11provided by MGI
Official Full Name
homeobox A11provided by MGI
Primary source
MGI:MGI:96172
See related
Ensembl:ENSMUSG00000038210 Vega:OTTMUSG00000018883
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hox-1.9; Hoxa-11
Summary
This gene is located in a cluster of developmentally and temporally regulated genes on chromosome 6 encoding proteins involved in pattern formation. These proteins contain a characteristic DNA-binding motif called a homeodomain and function in transcriptional regulation. There are four distinct clusters of related genes on chromosomes 2, 6, 11, and 15. The protein encoded by this gene is important in the development of the skeleton, limbs, and urogenital tract. Expression of this gene may be regulated by overlapping transcription from an adjacent locus on the opposite strand (GeneID: 15397). [provided by RefSeq, Mar 2013]
Expression
Biased expression in colon adult (RPKM 45.9), limb E14.5 (RPKM 35.6) and 3 other tissues See more
Orthologs

Genomic context

See Hoxa11 in Genome Data Viewer
Location:
6 B3; 6 25.4 cM
Exon count:
2
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (52242105..52245810, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (52192105..52195766, complement)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene microRNA 196b Neighboring gene homeobox A10 Neighboring gene homeobox A11, opposite strand Neighboring gene homeobox A13 Neighboring gene Hoxa distal transcript antisense RNA

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
anterior/posterior pattern specification IGI
Inferred from Genetic Interaction
more info
PubMed 
bone development IMP
Inferred from Mutant Phenotype
more info
PubMed 
branching involved in ureteric bud morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
cartilage development involved in endochondral bone morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
developmental growth IGI
Inferred from Genetic Interaction
more info
PubMed 
dorsal/ventral pattern formation IGI
Inferred from Genetic Interaction
more info
PubMed 
embryonic digit morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
embryonic forelimb morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
embryonic limb morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
embryonic skeletal joint morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
male gonad development IGI
Inferred from Genetic Interaction
more info
PubMed 
male gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
mesodermal cell fate specification IDA
Inferred from Direct Assay
more info
PubMed 
metanephros development IGI
Inferred from Genetic Interaction
more info
PubMed 
multicellular organism development IDA
Inferred from Direct Assay
more info
PubMed 
organ induction IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell development IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of chondrocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
proximal/distal pattern formation IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of chondrocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
single fertilization IGI
Inferred from Genetic Interaction
more info
PubMed 
single fertilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
skeletal system development IGI
Inferred from Genetic Interaction
more info
PubMed 
skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
spermatogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
uterus development IGI
Inferred from Genetic Interaction
more info
PubMed 
uterus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
protein-DNA complex IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
homeobox protein Hox-A11
Names
homeo box A11
homeobox protein Hox-1.9

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010450.3NP_034580.1  homeobox protein Hox-A11

    See identical proteins and their annotated locations for NP_034580.1

    Status: REVIEWED

    Source sequence(s)
    AC015583, AK133481
    Consensus CDS
    CCDS20148.1
    UniProtKB/Swiss-Prot
    P31311
    Related
    ENSMUSP00000040920.8, OTTMUSP00000020426, ENSMUST00000048026.9, OTTMUST00000045416
    Conserved Domains (2) summary
    pfam00046
    Location:244297
    Homeobox; Homeobox domain
    pfam12045
    Location:26168
    DUF3528; Protein of unknown function (DUF3528)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

    Range
    52242105..52245810 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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