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CYLC2 cylicin 2 [ Homo sapiens (human) ]

Gene ID: 1539, updated on 21-Dec-2019

Summary

Official Symbol
CYLC2provided by HGNC
Official Full Name
cylicin 2provided by HGNC
Primary source
HGNC:HGNC:2583
See related
Ensembl:ENSG00000155833 MIM:604035
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Cylicin II (CYCL2) is specifically expressed in testis and is part of the cytoskeletal calyx of mammalian sperm heads. Cylicin II may play a role in the morphogenesis of the sperm head. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 24.8) See more
Orthologs

Genomic context

See CYLC2 in Genome Data Viewer
Location:
9q31.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (102995333..103018488)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (105757593..105780770)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 587 Neighboring gene zyg-11 family member A, cell cycle regulator pseudogene 1 Neighboring gene phosphoribosyl pyrophosphate synthetase 2 pseudogene Neighboring gene uncharacterized LOC105376191 Neighboring gene long intergenic non-protein coding RNA 1492

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Cross-Disorder Genome-Wide Analyses Suggest a Complex Genetic Relationship Between Tourette's Syndrome and OCD.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC129591

Gene Ontology Provided by GOA

Function Evidence Code Pubs
structural constituent of cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoskeletal calyx IEA
Inferred from Electronic Annotation
more info
 
nucleus HDA PubMed 

General protein information

Preferred Names
cylicin-2
Names
cylicin II
cylicin, basic protein of sperm head cytoskeleton 2
multiple-band polypeptide II

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001340.5NP_001331.1  cylicin-2

    See identical proteins and their annotated locations for NP_001331.1

    Status: REVIEWED

    Source sequence(s)
    AL449304, BC058038, Z46788
    Consensus CDS
    CCDS35085.1
    UniProtKB/Swiss-Prot
    Q14093
    UniProtKB/TrEMBL
    A0A024R146, Q6PEJ5
    Related
    ENSP00000420256.1, ENST00000374798.8
    Conserved Domains (1) summary
    pfam15241
    Location:9113
    Cylicin_N; Cylicin N-terminus

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    102995333..103018488
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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