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CYLC2 cylicin 2 [ Homo sapiens (human) ]

Gene ID: 1539, updated on 19-Sep-2024

Summary

Official Symbol
CYLC2provided by HGNC
Official Full Name
cylicin 2provided by HGNC
Primary source
HGNC:HGNC:2583
See related
Ensembl:ENSG00000155833 MIM:604035; AllianceGenome:HGNC:2583
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Cylicin II (CYCL2) is specifically expressed in testis and is part of the cytoskeletal calyx of mammalian sperm heads. Cylicin II may play a role in the morphogenesis of the sperm head. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 24.8) See more
Orthologs
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Genomic context

See CYLC2 in Genome Data Viewer
Location:
9q31.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (102995333..103018488)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (115169180..115192167)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (105757615..105780770)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 587 Neighboring gene zyg-11 family member A, cell cycle regulator pseudogene 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:105629405-105630604 Neighboring gene phosphoribosyl pyrophosphate synthetase 2 pseudogene Neighboring gene MPRA-validated peak7310 silencer Neighboring gene uncharacterized LOC105376191 Neighboring gene long intergenic non-protein coding RNA 1492 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:105948847-105949410 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:105949411-105949974 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:105999467-106000068 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:106000069-106000669 Neighboring gene NANOG hESC enhancer GRCh37_chr9:106027846-106028395

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Cross-Disorder Genome-Wide Analyses Suggest a Complex Genetic Relationship Between Tourette's Syndrome and OCD.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC129591

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables structural constituent of cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoskeletal calyx IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus HDA PubMed 

General protein information

Preferred Names
cylicin-2
Names
cylicin II
cylicin, basic protein of sperm head cytoskeleton 2
multiple-band polypeptide II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001340.5NP_001331.1  cylicin-2

    See identical proteins and their annotated locations for NP_001331.1

    Status: REVIEWED

    Source sequence(s)
    AL449304, BC058038, Z46788
    Consensus CDS
    CCDS35085.1
    UniProtKB/Swiss-Prot
    B2R8F4, Q14093, Q5VVJ9
    Related
    ENSP00000420256.1, ENST00000374798.8
    Conserved Domains (1) summary
    pfam15241
    Location:9113
    Cylicin_N; Cylicin N-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    102995333..103018488
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    115169180..115192167
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)