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RNF145 ring finger protein 145 [ Homo sapiens (human) ]

Gene ID: 153830, updated on 1-Jun-2020

Summary

Official Symbol
RNF145provided by HGNC
Official Full Name
ring finger protein 145provided by HGNC
Primary source
HGNC:HGNC:20853
See related
Ensembl:ENSG00000145860
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in lung (RPKM 33.4), gall bladder (RPKM 23.7) and 24 other tissues See more
Orthologs

Genomic context

See RNF145 in Genome Data Viewer
Location:
5q33.3
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (159157409..159210053, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (158584417..158637061, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene EBF transcription factor 1 Neighboring gene VISTA enhancer hs1123 Neighboring gene uncharacterized LOC107986467 Neighboring gene long intergenic non-protein coding RNA 2202 Neighboring gene uncharacterized LOC107986468 Neighboring gene long intergenic non-protein coding RNA 1932 Neighboring gene ubiquitin like domain containing CTD phosphatase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.
NHGRI GWA Catalog
New gene functions in megakaryopoiesis and platelet formation.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31951, FLJ44310, DKFZp686M11215

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
RING finger protein 145
NP_001186309.1
NP_001186310.1
NP_001186311.1
NP_001186312.1
NP_653327.1
XP_016864627.1
XP_024310151.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199380.1NP_001186309.1  RING finger protein 145 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK308394, AL831829, BC042684
    Consensus CDS
    CCDS56393.1
    UniProtKB/Swiss-Prot
    Q96MT1
    UniProtKB/TrEMBL
    Q8NDT8
    Related
    ENSP00000430955.1, ENST00000518802.5
    Conserved Domains (3) summary
    pfam12678
    Location:564605
    zf-rbx1; RING-H2 zinc finger
    pfam13639
    Location:565605
    zf-RING_2; Ring finger domain
    pfam13705
    Location:38536
    TRC8_N; TRC8 N-terminal domain
  2. NM_001199381.2NP_001186310.1  RING finger protein 145 isoform 3

    See identical proteins and their annotated locations for NP_001186310.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate 5' exon, as compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus, as compared to isoform 1.
    Source sequence(s)
    AK304435, AL697229, AL831829
    Consensus CDS
    CCDS56392.1
    UniProtKB/Swiss-Prot
    Q96MT1
    UniProtKB/TrEMBL
    Q8NDT8
    Related
    ENSP00000430753.2, ENST00000521606.6
    Conserved Domains (3) summary
    pfam12678
    Location:551592
    zf-rbx1; RING-H2 zinc finger
    pfam13639
    Location:552592
    zf-RING_2; Ring finger domain
    pfam13705
    Location:25523
    TRC8_N; TRC8 N-terminal domain
  3. NM_001199382.1NP_001186311.1  RING finger protein 145 isoform 4

    See identical proteins and their annotated locations for NP_001186311.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has an alternate 5' exon, as compared to variant 1. The resulting isoform (4) lacks a segment in the N-terminus, as compared to isoform 1.
    Source sequence(s)
    AK304228, AL831829, BC042684, DC418555
    Consensus CDS
    CCDS56391.1
    UniProtKB/Swiss-Prot
    Q96MT1
    UniProtKB/TrEMBL
    Q8NDT8
    Related
    ENSP00000429071.1, ENST00000520638.1
    Conserved Domains (3) summary
    pfam12678
    Location:548589
    zf-rbx1; RING-H2 zinc finger
    pfam13639
    Location:549589
    zf-RING_2; Ring finger domain
    pfam13705
    Location:22520
    TRC8_N; TRC8 N-terminal domain
  4. NM_001199383.2NP_001186312.1  RING finger protein 145 isoform 5

    See identical proteins and their annotated locations for NP_001186312.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has an alternate 5' exon, resulting in a downstream AUG start codon, as compared to variant 1. The resulting isoform (5) has a shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AK292854, AL831829, CK821118
    Consensus CDS
    CCDS56390.1
    UniProtKB/Swiss-Prot
    Q96MT1
    UniProtKB/TrEMBL
    A8K9Y9, Q8NDT8
    Related
    ENSP00000409064.2, ENST00000424310.6
    Conserved Domains (3) summary
    pfam12678
    Location:534575
    zf-rbx1; RING-H2 zinc finger
    pfam13639
    Location:535575
    zf-RING_2; Ring finger domain
    pfam13705
    Location:8506
    TRC8_N; TRC8 N-terminal domain
  5. NM_144726.2NP_653327.1  RING finger protein 145 isoform 2

    See identical proteins and their annotated locations for NP_653327.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' exon, as compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, as compared to isoform 1.
    Source sequence(s)
    AK056513, AL831829, BC042684
    Consensus CDS
    CCDS4344.1
    UniProtKB/Swiss-Prot
    Q96MT1
    UniProtKB/TrEMBL
    Q8NDT8
    Related
    ENSP00000274542.2, ENST00000274542.6
    Conserved Domains (3) summary
    pfam12678
    Location:562603
    zf-rbx1; RING-H2 zinc finger
    pfam13639
    Location:563603
    zf-RING_2; Ring finger domain
    pfam13705
    Location:36534
    TRC8_N; TRC8 N-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    159157409..159210053 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009138.2XP_016864627.1  RING finger protein 145 isoform X2

    UniProtKB/Swiss-Prot
    Q96MT1
    Conserved Domains (3) summary
    pfam12678
    Location:534575
    zf-rbx1; RING-H2 zinc finger
    pfam13639
    Location:535575
    zf-RING_2; Ring finger domain
    pfam13705
    Location:8506
    TRC8_N; TRC8 N-terminal domain
  2. XM_024454383.1XP_024310151.1  RING finger protein 145 isoform X1

    Conserved Domains (3) summary
    pfam13705
    Location:24522
    TRC8_N; TRC8 N-terminal domain
    cd16684
    Location:549591
    RING-H2_RNF145; RING finger, H2 subclass, found in RING finger protein 145 (RNF145) and similar proteins
    cl26329
    Location:536641
    zf-rbx1; RING-H2 zinc finger domain
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